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公开(公告)号:US20160060642A1
公开(公告)日:2016-03-03
申请号:US14781893
申请日:2014-04-16
Inventor: Stephen Trowell , Alisha Anderson , Muhammed Tehseen , Mira Dumancic , Lyndall Briggs , Jian Wang
IPC: C12N15/81 , C07K14/435 , G01N33/74 , C12Q1/02 , G01N33/64
CPC classification number: C12N15/81 , C07K14/43545 , C07K14/705 , C12Q1/025 , G01N33/56961 , G01N33/64 , G01N33/74 , G01N2333/4353 , G01N2333/43534 , G01N2333/726
Abstract: The present invention relates to a yeast cell expressing a nematode G protein coupled receptor (GPCR), whereby ligand binding to the GPCR results in a detectable signal. In particular, the present invention relates to a yeast library expressing a range of different GPCRs, and to methods of screening said library.
Abstract translation: 本发明涉及表达线虫G蛋白偶联受体(GPCR)的酵母细胞,其中与GPCR结合的配体产生可检测的信号。 特别地,本发明涉及表达一系列不同GPCR的酵母文库,以及筛选所述文库的方法。