公开(公告)号：US20230053833A1

公开(公告)日：2023-02-23

申请号：US17786360

申请日：2019-12-19

Applicant: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION

Inventor： John TSANAKTSIDIS ,  Cecily ELDRIDGE ,  Scott COURTNEY

IPC: C07C29/62

Abstract: A process for continuous preparation of halogenated alkoxyethane of general formula XClHC—CF2OR, where X is —Cl or —F and OR is C1-4 alkoxy, the process comprising a step of introducing in a flow reactor reaction components comprising (i) a compound of general formula XClC═CF2, (ii) abase, and (iii) a C1-4 alkanol, wherein a) the flow reactor comprises one or more tubular flow line(s) having an internal cross-sectional area of less than 115 mm2 through which the reaction components flow as a reaction mixture, and b) the halogenated alkoxyethane is formed at least upon the reaction components mixing, with the so formed halogenated alkoxyethane flowing out of the flow reactor in a reactor effluent.

公开(公告)号：US20240317661A1

公开(公告)日：2024-09-26

申请号：US18571585

申请日：2022-06-17

Applicant: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION

Inventor： John TSANAKTSIDIS ,  Cecily ELDRIDGE ,  Scott COURTNEY

IPC: C07C41/06 ,  C07C41/42

CPC classification number: C07C41/06 ,  C07C41/42

Abstract: A process for continuous preparation of halogenated alkoxyethane of general formula XClHC—CF2OR, where X is —Cl or —F and OR is C1-4 alkoxy, the process comprising a step of introducing in a plate reactor reaction components comprising (i) a compound of general formula XClC═CF2, (ii) a base, and (iii) a C1-4 alkanol, wherein a) the plate reactor comprises a fluidic module defining one or more fluidic path(s) through which the reaction components flow as a reaction mixture, and b) the halogenated alkoxyethane is formed at least upon the reaction components mixing, with the so formed halogenated alkoxyethane flowing out of the plate reactor in a reactor effluent.

公开(公告)号：US20230041468A1

公开(公告)日：2023-02-09

申请号：US17786048

申请日：2019-12-19

Applicant: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION

Inventor： John TSANAKTSIDIS ,  Cecily ELDRIDGE ,  Scott COURTNEY

IPC: C07C41/16 ,  B01J19/18 ,  C07C41/38

Abstract: A process for continuous preparation of halogenated alkoxyethane of general formula XClHC—CF2OR, where X is —Cl or -f and OR is C1-4 alkoxy, the process comprising a step of introducing in a flow reactor reaction components comprising (i) a compound of general formula XClHC—CYF2, where each of X and Y is independently —Cl or —F, (ii) a base, and (iii) a C1-4 alkanol, wherein a) the flow reactor comprises one or more tubular flow line(s) through which the reaction components flow as a reaction mixture, c) the halogenated alkoxyethane is formed at least upon the reaction components mixing, with the so formed halogenated alkoxyethane flowing out of the flow reactor in a reactor effluent, and b) the base is one that forms a salt soluble in the alkanol during formation of the halogenated alkoxyethane.