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公开(公告)号：WO2016024279A1
公开(公告)日：2016-02-18
申请号：PCT/IL2015/050824
申请日：2015-08-12
Applicant: CONVERGENT R.N.R LTD
Inventor： HAREL, Zeev , BURSHTEIN ZEEV, Zeev , BAR-DAVID, Aharon , MARKOVICH, Miri
CPC classification number: A61M37/00 , A61K9/0009 , A61K41/00 , A61K41/0052 , A61M2037/0007 , A61N5/10 , A61N2005/1091 , A61N2005/1098
Abstract: The present invention provides a method for activating a pro-drug in vivo comprising the steps of: (a) administering a pro-drag to a subject; (b) locating a target site which has been at least partially dosed with the pro-drug at a predetermined concentration; and (d) exposing the target site to X-ray radiation. The step of exposing the target site to X-ray radiation is characterized by providing a converging X-ray of a controllable waist, substantially uniform at the target site, sufficient to convert the pro-drug to an active drug, whilst the X-ray photon dosage at the target site is higher than the X-ray photon dosage at an adjacent non target site.
Abstract translation: 本发明提供了一种在体内活化前药的方法，包括以下步骤：（a）向受试者施用阻遏物; （b）将至少部分给予前药的目标部位定位在预定浓度下; 和（d）将目标部位暴露于X射线辐射。 将目标部位暴露于X射线辐射的步骤的特征在于提供可控腰部的会聚X射线，其在目标部位基本均匀，足以将前药转化为活性药物，同时X射线 目标位点的光子剂量高于相邻非靶位点处的X射线光子剂量。
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公开(公告)号：EP3180085A1
公开(公告)日：2017-06-21
申请号：EP15832565.4
申请日：2015-08-12
Applicant: Convergent R.N.R Ltd
Inventor： HAREL, Zeev , BURSHTEIN ZEEV, Zeev , BAR-DAVID, Aharon , MARKOVICH, Miri
CPC classification number: A61M37/00 , A61K9/0009 , A61K41/00 , A61K41/0052 , A61M2037/0007 , A61N5/10 , A61N2005/1091 , A61N2005/1098
Abstract: The present invention provides a method for activating a pro-drug in vivo comprising the steps of: (a) administering a pro-drag to a subject; (b) locating a target site which has been at least partially dosed with the pro-drug at a predetermined concentration; and (d) exposing the target site to X-ray radiation. The step of exposing the target site to X-ray radiation is characterized by providing a converging X-ray of a controllable waist, substantially uniform at the target site, sufficient to convert the pro-drug to an active drug, while the X-ray photon dosage at the target site is higher than the X-ray photon dosage at an adjacent non target site.
Abstract translation: 本发明提供了一种活体内激活前体药物的方法，其包括以下步骤：（a）将前体药物施用于受试者; （b）将已经至少部分用前药给药的靶位点定位在预定浓度; 和（d）将目标部位暴露于X射线辐射。 使目标部位暴露于X射线辐射的步骤的特征在于提供可控腰部的会聚X射线，其在目标部位基本均匀，足以将前药转化为活性药物，而X射线 目标部位的光子剂量高于相邻非目标部位的X射线光子剂量。
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公开(公告)号：EP3180085B1
公开(公告)日：2020-10-07
申请号：EP15832565.4
申请日：2015-08-12
Applicant: Convergent R.N.R Ltd
Inventor： HAREL, Zeev , BURSHTEIN ZEEV, Zeev , BAR-DAVID, Aharon , MARKOVICH, Miri
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