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Patent Agency Ranking1.发明申请RECOMBINANT C140 RECEPTOR, ITS AGONISTS AND ANTAGONISTS, AND NUCLEIC ACIDS ENCODING THE RECEPTOR 审中-公开重组C140受体，其激素和拮抗剂以及编码受体的核酸
公开(公告)号：WO1996023225A1
公开(公告)日：1996-08-01
申请号：PCT/US1996001179
申请日：1996-01-25
Applicant: COR THERAPEUTICS, INC.
Inventor： COR THERAPEUTICS, INC. , SUNDELIN, Johan , SCARBOROUGH, Robert, M.
IPC: G01N33/53
CPC classification number: C07K14/723 , A61K38/00 , A61K48/00
Abstract: Nucleic acid molecules encoding the C140 cell surface receptor have been cloned and sequenced. The availability of C140 receptor DNA permits the recombinant production of the C140 receptor which can be produced on the surface of a cell, including an oocyte. The nucleic acid molecules are useful in an assay for detecting a substance which affects C140 receptor activity, either receptor agonists or antagonists. Further, the elucidation of the structure of the C140 receptor permits the design of agonist and antagonist compounds which are useful in such assays. The availability of the C140 receptor also permits production of antibodies specifically immunoreactive with one or more antigenic epitopes of the C140 receptor.
Abstract translation: 编码C140细胞表面受体的核酸分子已被克隆并测序。 C140受体DNA的可用性允许重组产生可在细胞表面（包括卵母细胞）上产生的C140受体。 核酸分子可用于检测影响C140受体活性的物质，即受体激动剂或拮抗剂。 此外，阐明C140受体的结构允许设计可用于此类测定中的激动剂和拮抗剂化合物。 C140受体的可用性还允许产生与C140受体的一个或多个抗原表位特异性免疫反应的抗体。
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公开(公告)号：WO1995003318A1
公开(公告)日：1995-02-02
申请号：PCT/US1994008536
申请日：1994-07-26
Applicant: COR THERAPEUTICS
Inventor： COR THERAPEUTICS , SCARBOROUGH, Robert, M. , SUNDELIN, Johan
IPC: C07H21/00
CPC classification number: C07K7/06 , A61K38/00 , A61K48/00 , C07K7/08 , C07K14/723
Abstract: The DNA encoding the C140 cell surface receptor has been cloned and sequenced. The availability of this DNA permits the recombinant production of the C140 receptor which can be produced at cell or oocyte surfaces and is useful in assay systems both for the detection of substances which affect its activity, including agonists and antagonists. Further, the elucidation of the structure of the C140 receptor permits the design of agonist and antagonist compounds which are useful in these assays. The availability of the C140 receptor also permits production of antibodies specifically immunoreactive with the receptor per se or with specific regions thereof.
Abstract translation: 编码C140细胞表面受体的DNA已被克隆并测序。 该DNA的可用性允许重组产生可在细胞或卵母细胞表面产生的C140受体，并且可用于检测影响其活性的物质（包括激动剂和拮抗剂）的测定系统中。 此外，阐明C140受体的结构允许设计可用于这些测定中的激动剂和拮抗剂化合物。 C140受体的可用性还允许产生与受体本身或其特定区域特异性免疫反应的抗体。
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公开(公告)号：EP0804452A1
公开(公告)日：1997-11-05
申请号：EP94925135.0
申请日：1994-07-26
Applicant: COR THERAPEUTICS, INC.
Inventor： SCARBOROUGH, Robert, M. , SUNDELIN, Johan
CPC classification number: C07K7/06 , A61K38/00 , A61K48/00 , C07K7/08 , C07K14/723
Abstract: The DNA encoding the C140 cell surface receptor has been cloned and sequenced. The availability of this DNA permits the recombinant production of the C140 receptor which can be produced at cell or oocyte surfaces and is useful in assay systems both for the detection of substances which affect its activity, including agonists and antagonists. Further, the elucidation of the structure of the C140 receptor permits the design of agonist and antagonist compounds which are useful in these assays. The availability of the C140 receptor also permits production of antibodies specifically immunoreactive with the receptor per se or with specific regions thereof.
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公开(公告)号：EP0804452B1
公开(公告)日：2001-09-12
申请号：EP94925135.9
申请日：1994-07-26
Applicant: COR THERAPEUTICS, INC.
Inventor： SCARBOROUGH, Robert, M. , SUNDELIN, Johan
CPC classification number: C07K7/06 , A61K38/00 , A61K48/00 , C07K7/08 , C07K14/723
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5.发明公开RECOMBINANT C140 RECEPTOR, ITS AGONISTS AND ANTAGONISTS, AND NUCLEIC ACIDS ENCODING THE RECEPTOR 失效重组C140受体，及其激动剂和拮抗剂，和受体编码核酸
公开(公告)号：EP0870198A1
公开(公告)日：1998-10-14
申请号：EP96904515.0
申请日：1996-01-25
Applicant: COR THERAPEUTICS, INC.
Inventor： SUNDELIN, Johan , SCARBOROUGH, Robert, M.
IPC: C12N15 , A61K31 , A61K48 , A61P43 , C07H21 , C07K7 , C07K14 , C07K16 , C12N5 , C12P21 , C12Q1 , G01N33 , A61K38 , C12R1
CPC classification number: C07K14/723 , A61K38/00 , A61K48/00
Abstract: Nucleic acid molecules encoding the C140 cell surface receptor have been cloned and sequenced. The availability of C140 receptor DNA permits the recombinant production of the C140 receptor which can be produced on the surface of a cell, including an oocyte. The nucleic acid molecules are useful in an assay for detecting a substance which affects C140 receptor activity, either receptor agonists or antagonists. Further, the elucidation of the structure of the C140 receptor permits the design of agonist and antagonist compounds which are useful in such assays. The availability of the C140 receptor also permits production of antibodies specifically immunoreactive with one or more antigenic epitopes of the C140 receptor.
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