公开(公告)号：WO1998022500A2

公开(公告)日：1998-05-28

申请号：PCT/US1997022422

申请日：1997-11-21

Applicant: COR THERAPEUTICS, INC.

Inventor： COR THERAPEUTICS, INC. ,  JENKINS, Alison, L. ,  PHILLIPS, David, R.

IPC: C07K14/405

CPC classification number: C07K14/70546 ,  A61K38/00 ,  C07K14/70557

Abstract: The present invention describes a direct interaction between myosin and the cytoplasmic domain of membrane proteins, particularly the phosphorylated cytoplasmic domains of the beta -subunit of integrins. The invention provides methods of identifying agents which block integrin binding to myosin, methods of using agents which block integrin binding to myosin to modulate biological and pathological processes, and provides agents that block integrin mediated binding to myosin and thereby modulate related cellular or cellular component movement.

Abstract translation: 本发明描述了肌球蛋白和膜蛋白的细胞质结构域之间的直接相互作用，特别是整联蛋白β亚单位的磷酸化胞质结构域。 本发明提供鉴定阻断整合素与肌球蛋白结合的试剂的方法，使用阻断整合素结合肌球蛋白以调节生物学和病理学过程的试剂的方法，以及提供阻断整合素介导的结合肌球蛋白从而调节相关细胞或细胞成分运动的试剂 。

公开(公告)号：EP0942931A2

公开(公告)日：1999-09-22

申请号：EP97952309.0

申请日：1997-11-21

Applicant: COR THERAPEUTICS, INC.

Inventor： JENKINS, Alison, L. ,  PHILLIPS, David, R.

IPC: A61K45 ,  A61K38 ,  A61P7 ,  A61P9 ,  A61P21 ,  A61P29 ,  A61P35 ,  C07K14

CPC classification number: C07K14/70546 ,  A61K38/00 ,  C07K14/70557

Abstract: The present invention describes a direct interaction between myosin and the cytoplasmic domain of membrane proteins, particularly the phosphorylated cytoplasmic domains of the β-subunit of integrins. The invention provides methods of identifying agents which block integrin binding to myosin, methods of using agents which block integrin binding to myosin to modulate biological and pathological processes, and provides agents that block integrin mediated binding to myosin and thereby modulate related cellular or cellular component movement.