公开(公告)号：WO1997014432A1

公开(公告)日：1997-04-24

申请号：PCT/US1996016790

申请日：1996-10-18

Applicant: COR THERAPEUTICS, INC.

Inventor： COR THERAPEUTICS, INC. ,  PHILIPS, David ,  LAW, Debbie, A. ,  ALAIMO, Lisa, N.

IPC: A61K39/00

CPC classification number: C07K14/70546

Abstract: The present invention discloses that phosphorylation of cytoplasmic tyrosine residues in the beta -subunit of integrins is needed for signal protein association. The invention provides methods of identifying signaling partners involved in integrin mediated signaling, methods of identifying agents which block integrin mediated signaling, methods of using agents which block intergrin mediated signaling to modulate biological and pathological processes, and agents which block integrin mediated signaling.

Abstract translation: 本发明公开了信号蛋白结合所需的β亚单位的胞质酪氨酸残基的磷酸化。 本发明提供识别参与整联蛋白介导的信号传导的信号载体的方法，鉴定阻断整联蛋白介导信号传导的试剂的方法，使用阻断整合蛋白介导的信号传导调节生物和病理过程的试剂的方法，以及阻断整合素介导的信号传导的试剂。

公开(公告)号：EP0801574A1

公开(公告)日：1997-10-22

申请号：EP96936741.0

申请日：1996-10-18

Applicant: COR THERAPEUTICS, INC.

Inventor： PHILIPS, David ,  LAW, Debbie A. ,  ALAIMO, Lisa N.

IPC: G01N33 ,  A61K38 ,  A61K45 ,  A61P7 ,  A61P9 ,  A61P29 ,  A61P35 ,  A61P43 ,  C07K14 ,  C12N5 ,  C12N11 ,  C12N15

CPC classification number: C07K14/70546

Abstract: The present invention discloses that phosphorylation of cytoplasmic tyrosine residues in the β-subunit of integrins is needed for signal protein association. The invention provides methods of identifying signaling partners involved in integrin mediated signaling, methods of identifying agents which block integrin mediated signaling, methods of using agents which block intergrin mediated signaling to modulate biological and pathological processes, and agents which block integrin mediated signaling.