公开(公告)号：WO2002016599A3

公开(公告)日：2002-02-28

申请号：PCT/US2001/026510

申请日：2001-08-27

Applicant: CURAGEN CORPORATION ,  COR THERAPEUTICS, INC. ,  BURGESS, Catherine, E. ,  CONLEY, Pamela, B. ,  GROSSE, William, M. ,  HART, Matthew ,  KEKUDA, Ramesh ,  SHIMKETS, Richard, A. ,  SPYTEK, Kimberly, A. ,  SZEKERES, Edward, S., Jr. ,  TOMLINSON, James, E. ,  TOPPER, James, N. ,  YANG, Ruey-Bin

Inventor： BURGESS, Catherine, E. ,  CONLEY, Pamela, B. ,  GROSSE, William, M. ,  HART, Matthew ,  KEKUDA, Ramesh ,  SHIMKETS, Richard, A. ,  SPYTEK, Kimberly, A. ,  SZEKERES, Edward, S., Jr. ,  TOMLINSON, James, E. ,  TOPPER, James, N. ,  YANG, Ruey-Bin

IPC: C12N15/00

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses tehrapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：WO1992013867A1

公开(公告)日：1992-08-20

申请号：PCT/US1992000730

申请日：1992-01-28

Applicant: COR THERAPEUTICS, INC. ,  ESCOBEDO, Jaime, A. ,  WILLIAMS, Lewis, T.

Inventor： COR THERAPEUTICS, INC. ,  WOLF, David ,  TOMLINSON, James, E. ,  FRETTO, Larry, J. ,  GIESE, Neill, A.

IPC: C07H15/12

CPC classification number: C07K16/2863 ,  A61K38/00 ,  C07K14/71 ,  C07K2319/00

Abstract: Defined constructs of modified human platelet-derived growth factor receptor polypeptides are provided. Extracellular region domain structures are identified and modifications and combinatorial rearrangements of the receptor segments are provided. Both cell bound and soluble forms of modified segments are made available, as are methods for assays using them, allowing for screening or ligand analogues.

Abstract translation: 提供修饰的人血小板衍生生长因子受体多肽的定义构建体。 鉴定细胞外区域结构，并提供受体区段的修饰和组合重排。 修饰片段的细胞结合和可溶形式均可获得，使用它们的测定方法也可用于筛选或配体类似物。

公开(公告)号：WO2002070707A3

公开(公告)日：2002-09-12

申请号：PCT/US2001/049168

申请日：2001-12-18

Applicant: CURAGEN CORPORATION ,  COR THERAPEUTICS, INC. ,  PADIGARU, Muralidhara ,  GERLACH, Valerie, L. ,  SMITHSON, Glennda ,  STONE, David ,  BIN-YANG, Ruey ,  CONLEY, Pamela ,  HART, Matthew ,  TOMLINSON, James, E. ,  TOPPER, James, N. ,  KEKUDA, Ramesh ,  CASMAN, Stacie, J. ,  EDINGER, Schlomit ,  MACDOUGALL, John, R.

Inventor： PADIGARU, Muralidhara ,  GERLACH, Valerie, L. ,  SMITHSON, Glennda ,  STONE, David ,  BIN-YANG, Ruey ,  CONLEY, Pamela ,  HART, Matthew ,  TOMLINSON, James, E. ,  TOPPER, James, N. ,  KEKUDA, Ramesh ,  CASMAN, Stacie, J. ,  EDINGER, Schlomit ,  MACDOUGALL, John, R.

IPC: C12N15/12

Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：EP0619836A1

公开(公告)日：1994-10-19

申请号：EP93900825.0

申请日：1992-12-01

Applicant: COR THERAPEUTICS, INC.

Inventor： WOLF, David ,  TOMLINSON, James, E.

IPC: C12N5 ,  C07K14 ,  C12N1 ,  C12N15 ,  C12P21 ,  A61K38 ,  C12R1

CPC classification number: C07K14/71 ,  A61K38/00

Abstract: Lignées cellulaires et procédés de production très efficiente de peptides solubles présentant une activité de liaison de ligand du facteur de croissance dérivé des plaquettes (PDGF). On décrit des lignées cellulaires qui sécrètent des fragments solubles à partir de régions extracellulaires des polypeptides récepteurs de PDGF (PDGF-R). On décrit également des procédés utilisant lesdites lignées cellulaires pour produire ces fragments.

公开(公告)号：EP0584082B1

公开(公告)日：2000-05-31

申请号：EP92906305.5

申请日：1992-01-28

Applicant: COR THERAPEUTICS, INC. ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： ESCOBEDO, Jaime, A. ,  WILLIAMS, Lewis, T. ,  WOLF, David ,  TOMLINSON, James, E. ,  FRETTO, Larry, J. ,  GIESE, Neill, A.

IPC: C12N15/12 ,  C12N5/10 ,  C12Q1/68 ,  C07K14/475 ,  C07K14/71 ,  A61K38/18

CPC classification number: C07K16/2863 ,  A61K38/00 ,  C07K14/71 ,  C07K2319/00

Abstract: Defined constructs of modified human platelet-derived growth factor receptor polypeptides are provided. Extracellular region domain structures are identified and modifications and combinatorial rearrangements of the receptor segments are provided. Both cell bound and soluble forms of modified segments are made available, as are methods for assays using them, allowing for screening or ligand analogues.

公开(公告)号：EP0584082A1

公开(公告)日：1994-03-02

申请号：EP92906305.0

申请日：1992-01-28

Applicant: COR THERAPEUTICS, INC. ,  ESCOBEDO, Jaime, A. ,  WILLIAMS, Lewis, T.

Inventor： ESCOBEDO, Jaime, A. ,  WILLIAMS, Lewis, T. ,  WOLF, David ,  TOMLINSON, James, E. ,  FRETTO, Larry, J. ,  GIESE, Neill, A.

IPC: A61K39 ,  C07K7 ,  C07K14 ,  C07K16 ,  C12N5 ,  C12N15 ,  C12P21 ,  G01N33 ,  A61K38 ,  C12R1

CPC classification number: C07K16/2863 ,  A61K38/00 ,  C07K14/71 ,  C07K2319/00

Abstract: On décrit des produits de recombinaison de polypeptides modifiés récepteurs du facteur de croissance dérivé de plaquettes humaines. Des structures de domaines des régions extracellulaires sont identifiées et des réagencements combinatoires des segments récepteurs sont décrits. Des formes solubles ainsi que des formes à liaison cellulaire de segments modifiés sont disponibles, ainsi que des procédés de titrage les utilisant, permettant la détection d'analogues de ligand.