公开(公告)号：AU730864B2

公开(公告)日：2001-03-15

申请号：AU7458696

申请日：1996-10-18

Applicant: COR THERAPEUTICS INC

Inventor： PHILIPS DAVID ,  LAW DEBBIE A ,  ALAIMO LISA N

IPC: G01N33/53 ,  A61K38/00 ,  A61K45/00 ,  A61P7/02 ,  A61P9/00 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07K14/705 ,  C12N5/06 ,  C12N11/02 ,  C12N15/09 ,  A61K39/00 ,  A61K39/38 ,  G01N33/574 ,  A01N37/18

Abstract: The present invention discloses that phosphorylation of cytoplasmic tyrosine residues in the beta-subunit of integrins is needed for signal protein association. The invention provides methods of identifying signaling partners involved in integrin mediated signaling, methods of identifying agents which block integrin mediated signaling, methods of using agents which block integrin mediated signaling to modulate biological and pathological processes, and agents which block integrin mediated signaling.

公开(公告)号：NZ321304A

公开(公告)日：2000-08-25

申请号：NZ32130496

申请日：1996-10-18

Applicant: COR THERAPEUTICS INC

Inventor： PHILIPS DAVID ,  LAW DEBBIE A ,  ALAIMO LISA N

IPC: G01N33/53 ,  A61K38/00 ,  A61K45/00 ,  A61P7/02 ,  A61P9/00 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07K14/705 ,  C12N5/06 ,  C12N11/02 ,  C12N15/09 ,  C07K14/00 ,  A61K39/00 ,  G01N33/574 ,  A61K39/38 ,  A01N37/18

Abstract: Use of an agent particularly a phosphorylated peptide which blocks the binding of a cytoplasmic signaling partner to an integrin having a phosphorylated tyrosine in the cytoplasmic domain of the beta subunit or a fragment thereof comprising the phosphorylated cytoplasmic domain in the preparation of a medicament for blocking the interaction of an integrin with a cytoplasmic signaling partner in a patient, like thrombosis, inflammation and tumor metastasis. The signalling partner is selected from the src-family of tyrosine kinases and the non-src family of tyrosine kinases. Further disclosed is an in vitro method for identifying agents which block the interaction of an integrin with a cytoplasmic signalling partner by: a) incubating a peptide comprising the phosphorylated cytoplasmic domain of the beta subunit of the integrin with the signalling partner and with an agent and; b) determining whether the agent blocks the binding of the signalling partner to the peptide.

公开(公告)号：EP0801574A4

公开(公告)日：2002-09-04

申请号：EP96936741

申请日：1996-10-18

Applicant: COR THERAPEUTICS INC

Inventor： PHILLIPS DAVID ,  LAW DEBBIE A ,  ALAIMO LISA N

IPC: G01N33/53 ,  A61K38/00 ,  A61K45/00 ,  A61P7/02 ,  A61P9/00 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07K14/705 ,  C12N5/06 ,  C12N11/02 ,  C12N15/09 ,  A61K39/00 ,  A01N37/18 ,  A61K39/38 ,  G01N33/574

CPC classification number: C07K14/70546

Abstract: The present invention discloses that phosphorylation of cytoplasmic tyrosine residues in the β-subunit of integrins is needed for signal protein association. The invention provides methods of identifying signaling partners involved in integrin mediated signaling, methods of identifying agents which block integrin mediated signaling, methods of using agents which block intergrin mediated signaling to modulate biological and pathological processes, and agents which block integrin mediated signaling.