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    PHARMACEUTICAL PYRAZOLE COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES
    1.
    发明申请
    PHARMACEUTICAL PYRAZOLE COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES 审中-公开
    用作蛋白激酶抑制剂的药用吡唑组合物

    公开(公告)号：WO9614843A3

    公开(公告)日：1996-05-23

    申请号：PCT/US9514723

    申请日：1995-11-09

    Applicant: COR THERAPEUTICS INC

    Inventor： GIESE NEILL A ,  LOKKER NATHALIE ,  LAIBELMAN ALAN M ,  SCARBOROUGH ROBERT M

    IPC: C07D231/38 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4439 ,  A61K31/455 ,  A61P43/00 ,  C07D231/40 ,  C07D401/06 ,  C07D405/04 ,  C07D409/06

    CPC classification number: A61K31/455 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/4439

    Abstract: A method for selectively inhibiting a kinase is disclosed, which comprises contacting a composition containing a kinase with a compound of formula (I), wherein: R1 is lower alkyl, lower hydrocarbyl, aryl lower alkyl, heteroaryl lower alkyl, 5- or 6-membered heterocyclic aromatic, polyaromatic, polyaromatic carbonyl, polyheteroaromatic or polyheteroaromatic carbonyl; R2 is lower alkyl, lower hydrocarbyl, aryl lower alkyl, heteroaryl lower alkyl, 5- or 6-membered heterocyclic aromatic, lower hydrocarboyl, 5- or 6-membered heterocyclic aromatic carbonyl, polyaromatic or polyheteroaromatic; R3 is H or lower alkyl; R5 is H, lower alkyl, lower hydrocarbyl, aryl lower alkyl, heteroaryl lower alkyl, 5- or 6-membered heterocyclic aromatic, halogen, or cyano; and R6 is H or lower hydrocarboyl. 00000

    Abstract translation: 公开了选择性抑制激酶的方法，其包括将含有激酶的组合物与式（I）化合物接触，其中：R 1是低级烷基，低级烃基，芳基低级烷基，杂芳基低级烷基，5-或6- 多芳基，多芳基羰基，多杂芳基或多杂芳基羰基; R 2是低级烷基，低级烃基，芳基低级烷基，杂芳基低级烷基，5-或6-元杂环芳族，低级烃基，5-或6-元杂环芳族羰基，多芳族或多杂芳族; R3是H或低级烷基; R5是H，低级烷基，低级烃基，芳基低级烷基，杂芳基低级烷基，5-或6-元杂环芳族，卤素或氰基; R6为H或低级烃基。 00000

    METHOD AND COMPOSITIONS FOR INHIBITING PROTEIN KINASES
    2.
    发明申请
    METHOD AND COMPOSITIONS FOR INHIBITING PROTEIN KINASES 审中-公开
    抑制蛋白激酶的方法和组合物

    公开(公告)号：WO9613259A2

    公开(公告)日：1996-05-09

    申请号：PCT/US9513882

    申请日：1995-10-26

    Applicant: COR THERAPEUTICS INC

    Inventor： GIESE NEILL A ,  LOKKER NATHALIE

    IPC: C12N9/99 ,  A61K31/365 ,  A61K31/366 ,  A61P35/02 ,  C07D313/00

    CPC classification number: A61K31/366 ,  A61K31/365

    Abstract: A method for selectively inhibiting a kinase is disclosed, which comprises contacting a composition containing a kinase with a molecule of formula (I) wherein R1 is H, lower alkyl, or lower alkanoyl; R2 is H, lower alkyl, or lower alkanoyl; R3 and R4 together represent a cis double bond or -O- or each of R3 and R4 independently represents H or OR; R5 is =O, =S, or -H, -OR; R6 and R7 together represent a double bond or -O- or each of R6 and R7 independently represents H or OR; R8 and R9 together represent a double bond or -O- or each of R8 and R9 independently represents H or OR; and each R independently represents H, lower alkyl, or lower alkanoyl.

    Abstract translation: 公开了选择性抑制激酶的方法，其包括将含有激酶的组合物与式（I）分子（其中R 1为H，低级烷基或低级烷酰基）接触; R2是H，低级烷基或低级烷酰基; R3和R4一起表示顺式双键或-O-或R 3和R 4各自独立地表示H或OR; R5为= O，= S或-H，-OR; R6和R7一起表示双键或-O-或R6和R7各自独立地表示H或OR; R8和R9一起表示双键或-O-或R8或R9各自独立地表示H或OR; 并且每个R独立地表示H，低级烷基或低级烷酰基。

    Method and compositions for inhibiting protein kinases
    4.
    发明专利
    Method and compositions for inhibiting protein kinases 未知

    公开(公告)号：AU4278996A

    公开(公告)日：1996-05-23

    申请号：AU4278996

    申请日：1995-10-26

    Applicant: COR THERAPEUTICS INC

    Inventor： GIESE NEILL A ,  LOKKER NATHALIE

    IPC: C12N9/99 ,  A61K31/365 ,  A61K31/366 ,  A61P35/02 ,  C07D313/00

    Abstract: A method for selectively inhibiting a kinase is disclosed, which comprises contacting a composition containing a kinase with a molecule of the formular alkanoyl; R2 is H, lower alkyl, or lower alkanoyl; R3 and R4 together represent a cis double bond or -O- or each of R3 and R4 independently represents H or OR; R5 is =O, =S, or -H, -OR; R6 and R7 together represent a double bond or -O- or each of R6 and R7 independently represents H or OR; R4 and R together represent a double bond or -O- or each of R8 and R9 independently represents H or OR; and each R independently represents H, lower alkyl, or lower alkanoyl.

    7.
    发明专利
    未知

    公开(公告)号：ES2170172T3

    公开(公告)日：2002-08-01

    申请号：ES95941340

    申请日：1995-10-26

    Applicant: COR THERAPEUTICS INC

    Inventor： GIESE NEILL A ,  LOKKER NATHALIE

    IPC: C12N9/99 ,  A61K31/365 ,  A61K31/366 ,  A61P35/02 ,  C07D313/00

    Abstract: A method for selectively inhibiting a kinase is disclosed, which comprises contacting a composition containing a kinase with a molecule of the formular alkanoyl; R2 is H, lower alkyl, or lower alkanoyl; R3 and R4 together represent a cis double bond or -O- or each of R3 and R4 independently represents H or OR; R5 is =O, =S, or -H, -OR; R6 and R7 together represent a double bond or -O- or each of R6 and R7 independently represents H or OR; R4 and R together represent a double bond or -O- or each of R8 and R9 independently represents H or OR; and each R independently represents H, lower alkyl, or lower alkanoyl.

    8.
    发明专利
    未知

    公开(公告)号：DE69524628T2

    公开(公告)日：2002-08-08

    申请号：DE69524628

    申请日：1995-10-26

    Applicant: COR THERAPEUTICS INC

    Inventor： GIESE A ,  LOKKER NATHALIE

    IPC: C12N9/99 ,  A61K31/365 ,  A61K31/366 ,  A61P35/02 ,  C07D313/00

    Abstract: A method for selectively inhibiting a kinase is disclosed, which comprises contacting a composition containing a kinase with a molecule of the formular alkanoyl; R2 is H, lower alkyl, or lower alkanoyl; R3 and R4 together represent a cis double bond or -O- or each of R3 and R4 independently represents H or OR; R5 is =O, =S, or -H, -OR; R6 and R7 together represent a double bond or -O- or each of R6 and R7 independently represents H or OR; R4 and R together represent a double bond or -O- or each of R8 and R9 independently represents H or OR; and each R independently represents H, lower alkyl, or lower alkanoyl.

    9.
    发明专利
    未知

    公开(公告)号：PT788356E

    公开(公告)日：2002-06-28

    申请号：PT95941340

    申请日：1995-10-26

    Applicant: COR THERAPEUTICS INC

    Inventor： GIESE NEILL A ,  LOKKER NATHALIE

    IPC: C12N9/99 ,  A61K31/365 ,  A61K31/366 ,  A61P35/02 ,  C07D313/00

    Abstract: A method for selectively inhibiting a kinase is disclosed, which comprises contacting a composition containing a kinase with a molecule of the formular alkanoyl; R2 is H, lower alkyl, or lower alkanoyl; R3 and R4 together represent a cis double bond or -O- or each of R3 and R4 independently represents H or OR; R5 is =O, =S, or -H, -OR; R6 and R7 together represent a double bond or -O- or each of R6 and R7 independently represents H or OR; R4 and R together represent a double bond or -O- or each of R8 and R9 independently represents H or OR; and each R independently represents H, lower alkyl, or lower alkanoyl.

    10.
    发明专利
    未知

    公开(公告)号：DK0788356T3

    公开(公告)日：2002-03-18

    申请号：DK95941340

    申请日：1995-10-26

    Applicant: COR THERAPEUTICS INC

    Inventor： GIESE NEILL A ,  LOKKER NATHALIE

    IPC: C12N9/99 ,  A61K31/365 ,  A61K31/366 ,  A61P35/02 ,  C07D313/00

    Abstract: A method for selectively inhibiting a kinase is disclosed, which comprises contacting a composition containing a kinase with a molecule of the formular alkanoyl; R2 is H, lower alkyl, or lower alkanoyl; R3 and R4 together represent a cis double bond or -O- or each of R3 and R4 independently represents H or OR; R5 is =O, =S, or -H, -OR; R6 and R7 together represent a double bond or -O- or each of R6 and R7 independently represents H or OR; R4 and R together represent a double bond or -O- or each of R8 and R9 independently represents H or OR; and each R independently represents H, lower alkyl, or lower alkanoyl.

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