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    FYN KINASE AS A TARGET FOR MODULATION OF INTEGRIN MEDIATED SIGNAL TRANSDUCTION
    2.
    发明申请
    FYN KINASE AS A TARGET FOR MODULATION OF INTEGRIN MEDIATED SIGNAL TRANSDUCTION 审中-公开
    FYN作为调整信号传输信号传输的目标

    公开(公告)号：WO0179144A3

    公开(公告)日：2002-02-28

    申请号：PCT/US0112039

    申请日：2001-04-13

    Applicant: COR THERAPEUTICS INC ,  COWAN KYRA J ,  LAW DEBBIE A ,  PHILLIPS DAVID R

    Inventor： COWAN KYRA J ,  LAW DEBBIE A ,  PHILLIPS DAVID R

    IPC: C07K14/705 ,  C12N9/12 ,  C07K14/00

    CPC classification number: C07K14/70557 ,  C07K14/7055 ,  C07K14/70553

    Abstract: The present invention describes a direct interaction between phosphorylated GPIIIa cytoplasmic domains with 1) src/ non- src family kinases and 2) phosphatases. The invention provides methods for identifying agents that block GPIIIa interactions with src/ non- scr family kinases and phosphatases, methods of using agents that block GPIIIa interactions with src/ non- src family kinases and PIP-1C phosphatases to modulate biological and pathological processes and agents that block GPIIIa mediated binding to src/ non- scr family kinases and PIP-1C phosphatases, thereby modulating related GPIIIa mediated signaling.

    Abstract translation: 本发明描述了磷酸化GPIIIa细胞质结构域与1）src /非src家族激酶和2）磷酸酶之间的直接相互作用。 本发明提供用于鉴定阻断GPIIIa与非特异性家族激酶和磷酸酶的GPIIIa相互作用的试剂的方法，使用阻断GPIIIa与src / 非激活家族激酶和PIP-1C磷酸酶调节生物学和病理学过程，并阻断GPIIIa介导的结合于src / 家族激酶和PIP-1C磷酸酶，从而调节相关的GPIIIa介导的信号传导。

    Use of a peptide agent such as a diphosphorylated peptide to modulate the interactions between myosin and integrins
    6.
    发明专利
    Use of a peptide agent such as a diphosphorylated peptide to modulate the interactions between myosin and integrins 未知

    公开(公告)号：NZ335932A

    公开(公告)日：2001-03-30

    申请号：NZ33593297

    申请日：1997-11-21

    Applicant: COR THERAPEUTICS INC

    Inventor： JENKINS ALISON L ,  PHILLIPS DAVID R

    IPC: A61K45/00 ,  A61K38/00 ,  A61P7/02 ,  A61P9/00 ,  A61P21/02 ,  A61P29/00 ,  A61P35/00 ,  C07K14/705 ,  C07K14/78 ,  C07K14/405 ,  A61K38/39

    Abstract: A method for identifying an agent, which modulates the interaction of an integrin with myosin, comprises the steps of: a) incubating a peptide comprising the phosphorylated cytoplasmic domain of the b-subunit of the integrin with myosin and with the agent, and b) determining whether the agent modulates the binding of myosin to the peptide. An agent that modulates the interaction of myosin and integrin is used in the manufacture of a medicament for modulating the direct interaction of an integrin with myosin in a cell. An agent that blocks the bonding of integrin to myosin is used in the manufacture of a medicament to block the direct interaction of an integrin with myosin such as reducing the severity of a pathological state mediated by direct integrin attachment to myosin. The agent can be a peptide sequence derived from the cytoplasmic domain of an integrin wherein the tyrosine residues are phosphorylated such as a diphosphorylated peptide corresponding to residues 740-762 of b3-subunit having the following sequence: Biotin-D-T-A-N-N-P-L-Y(PO3)-K-E-A-T-S-T-F-T-N-I-T-Y(PO3)-R-G-T-COOH (peptide 1).

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