公开(公告)号：DE69428292T2

公开(公告)日：2002-06-27

申请号：DE69428292

申请日：1994-07-26

Applicant: COR THERAPEUTICS INC

Inventor： SCARBOROUGH M ,  SUNDELIN JOHAN

IPC: C12N15/09 ,  A61K38/00 ,  A61K48/00 ,  C07H21/04 ,  C07K7/06 ,  C07K7/08 ,  C07K14/705 ,  C07K14/72 ,  C07K16/28 ,  C12N5/10 ,  C12P21/02 ,  C12R1/91 ,  C07H21/00 ,  C07K7/00 ,  C07K2/00

Abstract: The DNA encoding the C140 cell surface receptor has been cloned and sequenced. The availability of this DNA permits the recombinant production of the C140 receptor which can be produced at cell or oocyte surfaces and is useful in assay systems both for the detection of substances which affect its activity, including agonists and antagonists. Further, the elucidation of the structure of the C140 receptor permits the design of agonist and antagonist compounds which are useful in these assays. The availability of the C140 receptor also permits production of antibodies specifically immunoreactive with the receptor per se or with specific regions thereof.

公开(公告)号：CA2211176A1

公开(公告)日：1996-08-01

申请号：CA2211176

申请日：1996-01-25

Applicant: COR THERAPEUTICS INC

Inventor： SUNDELIN JOHAN ,  SCARBOROUGH ROBERT M

IPC: C12N15/09 ,  A61K31/00 ,  A61K31/70 ,  A61K31/7088 ,  A61K38/00 ,  A61K48/00 ,  A61P43/00 ,  C07H21/04 ,  C07K7/02 ,  C07K14/72 ,  C07K16/28 ,  C12N5/10 ,  C12N15/00 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  C12R1/91 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  C12N15/12 ,  C12Q1/02 ,  C07K7/06 ,  C07K7/08 ,  A61K51/10

Abstract: Nucleic acid molecules encoding the C140 cell surface receptor have been cloned and sequenced. The availability of C140 receptor DNA permits the recombinant production of the C140 receptor which can be produced on the surface of a cell, including an oocyte. The nucleic acid molecules are useful in an assay for detecting a substance which affects C140 receptor activity, either receptor agonists or antagonists. Further, the elucidation of the structure of the C140 receptor permits the design of agonist and antagonist compounds which are useful in such assays. The availability of the C140 receptor also permits production of antibodies specifically immunoreactive with one or more antigenic epitopes of the C140 receptor.

公开(公告)号：EP0804452A4

公开(公告)日：1998-08-12

申请号：EP94925135

申请日：1994-07-26

Applicant: COR THERAPEUTICS INC

Inventor： SCARBOROUGH ROBERT M ,  SUNDELIN JOHAN

IPC: C12N15/09 ,  A61K38/00 ,  A61K48/00 ,  C07H21/04 ,  C07K7/06 ,  C07K7/08 ,  C07K14/705 ,  C07K14/72 ,  C07K16/28 ,  C12N5/10 ,  C12P21/02 ,  C12R1/91 ,  C07H21/00 ,  C07K2/00 ,  C07K7/00

CPC classification number: C07K7/06 ,  A61K38/00 ,  A61K48/00 ,  C07K7/08 ,  C07K14/723

Abstract: The DNA encoding the C140 cell surface receptor has been cloned and sequenced. The availability of this DNA permits the recombinant production of the C140 receptor which can be produced at cell or oocyte surfaces and is useful in assay systems both for the detection of substances which affect its activity, including agonists and antagonists. Further, the elucidation of the structure of the C140 receptor permits the design of agonist and antagonist compounds which are useful in these assays. The availability of the C140 receptor also permits production of antibodies specifically immunoreactive with the receptor per se or with specific regions thereof.

公开(公告)号：EP0870198A4

公开(公告)日：2001-04-04

申请号：EP96904515

申请日：1996-01-25

Applicant: COR THERAPEUTICS INC

Inventor： SUNDELIN JOHAN ,  SCARBOROUGH ROBERT M

IPC: C12N15/09 ,  A61K31/00 ,  A61K31/70 ,  A61K31/7088 ,  A61K38/00 ,  A61K48/00 ,  A61P43/00 ,  C07H21/04 ,  C07K7/02 ,  C07K14/72 ,  C07K16/28 ,  C12N5/10 ,  C12N15/00 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  C12R1/91 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  A61K38/04 ,  A61K51/00 ,  C07H15/00 ,  C07K1/00 ,  C12N1/20 ,  C12N5/00 ,  C12P21/06

CPC classification number: C07K14/723 ,  A61K38/00 ,  A61K48/00

公开(公告)号：AT205502T

公开(公告)日：2001-09-15

申请号：AT94925135

申请日：1994-07-26

Applicant: COR THERAPEUTICS INC

Inventor： SCARBOROUGH ROBERT M ,  SUNDELIN JOHAN

IPC: C12N15/09 ,  A61K38/00 ,  A61K48/00 ,  C07H21/04 ,  C07K7/06 ,  C07K7/08 ,  C07K14/705 ,  C07K14/72 ,  C07K16/28 ,  C12N5/10 ,  C12P21/02 ,  C12R1/91 ,  C07H21/00 ,  C07K7/00 ,  C07K2/00

Abstract: The DNA encoding the C140 cell surface receptor has been cloned and sequenced. The availability of this DNA permits the recombinant production of the C140 receptor which can be produced at cell or oocyte surfaces and is useful in assay systems both for the detection of substances which affect its activity, including agonists and antagonists. Further, the elucidation of the structure of the C140 receptor permits the design of agonist and antagonist compounds which are useful in these assays. The availability of the C140 receptor also permits production of antibodies specifically immunoreactive with the receptor per se or with specific regions thereof.

公开(公告)号：NZ302524A

公开(公告)日：1999-05-28

申请号：NZ30252496

申请日：1996-01-25

Applicant: COR THERAPEUTICS INC

Inventor： SUNDELIN JOHAN ,  SCARBOROUGH ROBERT M

IPC: C12N15/09 ,  A61K31/00 ,  A61K31/70 ,  A61K31/7088 ,  A61K38/00 ,  A61K48/00 ,  A61P43/00 ,  C07H21/04 ,  C07K7/02 ,  C07K14/72 ,  C07K16/28 ,  C12N5/10 ,  C12N15/00 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  C12R1/91 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  C07K14/705 ,  C07K16/46 ,  C07K19/00 ,  A61K38/16 ,  A61K51/00

Abstract: Nucleic acid molecules encoding the C140 cell surface receptor have been cloned and sequenced. The availability of C140 receptor DNA permits the recombinant production of the C140 receptor which can be produced on the surface of a cell, including an oocyte. The nucleic acid molecules are useful in an assay for detecting a substance which affects C140 receptor activity, either receptor agonists or antagonists. Further, the elucidation of the structure of the C140 receptor permits the design of agonist and antagonist compounds which are useful in such assays. The availability of the C140 receptor also permits production of antibodies specifically immunoreactive with one or more antigenic epitopes of the C140 receptor.

公开(公告)号：NZ271516A

公开(公告)日：1997-01-29

申请号：NZ27151694

申请日：1994-07-26

Applicant: COR THERAPEUTICS INC

Inventor： SCARBOROUGH ROBERT MURRAY ,  SUNDELIN JOHAN

IPC: C12N15/09 ,  A61K38/00 ,  A61K48/00 ,  C07H21/04 ,  C07K7/06 ,  C07K7/08 ,  C07K14/705 ,  C07K14/72 ,  C07K16/28 ,  C12N5/10 ,  C12P21/02 ,  C12R1/91 ,  C12N15/12 ,  C12N15/63 ,  A61K39/395 ,  G01N33/566 ,  G01N33/567 ,  G01N33/577

Abstract: The DNA encoding the C140 cell surface receptor has been cloned and sequenced. The availability of this DNA permits the recombinant production of the C140 receptor which can be produced at cell or oocyte surfaces and is useful in assay systems both for the detection of substances which affect its activity, including agonists and antagonists. Further, the elucidation of the structure of the C140 receptor permits the design of agonist and antagonist compounds which are useful in these assays. The availability of the C140 receptor also permits production of antibodies specifically immunoreactive with the receptor per se or with specific regions thereof.

公开(公告)号：DE69428292D1

公开(公告)日：2001-10-18

申请号：DE69428292

申请日：1994-07-26

Applicant: COR THERAPEUTICS INC

Inventor： SCARBOROUGH M ,  SUNDELIN JOHAN

IPC: C12N15/09 ,  A61K38/00 ,  A61K48/00 ,  C07H21/04 ,  C07K7/06 ,  C07K7/08 ,  C07K14/705 ,  C07K14/72 ,  C07K16/28 ,  C12N5/10 ,  C12P21/02 ,  C12R1/91 ,  C07H21/00 ,  C07K7/00 ,  C07K2/00

Abstract: The DNA encoding the C140 cell surface receptor has been cloned and sequenced. The availability of this DNA permits the recombinant production of the C140 receptor which can be produced at cell or oocyte surfaces and is useful in assay systems both for the detection of substances which affect its activity, including agonists and antagonists. Further, the elucidation of the structure of the C140 receptor permits the design of agonist and antagonist compounds which are useful in these assays. The availability of the C140 receptor also permits production of antibodies specifically immunoreactive with the receptor per se or with specific regions thereof.

公开(公告)号：AU701822B2

公开(公告)日：1999-02-04

申请号：AU4859996

申请日：1996-01-25

Applicant: COR THERAPEUTICS INC

Inventor： SUNDELIN JOHAN ,  SCARBOROUGH ROBERT M

IPC: C12N15/09 ,  A61K31/00 ,  A61K31/70 ,  A61K31/7088 ,  A61K38/00 ,  A61K38/04 ,  A61K48/00 ,  A61K51/00 ,  A61P43/00 ,  C07H15/00 ,  C07H21/04 ,  C07K1/00 ,  C07K7/02 ,  C07K14/72 ,  C07K16/28 ,  C12N1/20 ,  C12N5/00 ,  C12N5/10 ,  C12N15/00 ,  C12P21/02 ,  C12P21/06 ,  C12P21/08 ,  C12Q1/68 ,  C12R1/91 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566

公开(公告)号：AU701677B2

公开(公告)日：1999-02-04

申请号：AU7516794

申请日：1994-07-26

Applicant: COR THERAPEUTICS INC

Inventor： SCARBOROUGH ROBERT M ,  SUNDELIN JOHAN

IPC: C12N15/09 ,  A61K38/00 ,  A61K48/00 ,  C07H21/04 ,  C07K7/06 ,  C07K7/08 ,  C07K14/705 ,  C07K14/72 ,  C07K16/28 ,  C12N5/10 ,  C12P21/02 ,  C12R1/91 ,  C07H21/00 ,  C07K7/00 ,  C07K15/00

Abstract: The DNA encoding the C140 cell surface receptor has been cloned and sequenced. The availability of this DNA permits the recombinant production of the C140 receptor which can be produced at cell or oocyte surfaces and is useful in assay systems both for the detection of substances which affect its activity, including agonists and antagonists. Further, the elucidation of the structure of the C140 receptor permits the design of agonist and antagonist compounds which are useful in these assays. The availability of the C140 receptor also permits production of antibodies specifically immunoreactive with the receptor per se or with specific regions thereof.