公开(公告)号：HU216318B

公开(公告)日：1999-06-28

申请号：HU549090

申请日：1990-06-15

Applicant: COR THERAPEUTICS INC

Inventor： CHARO ISRAEL F ,  SCARBOROUGH ROBERT M ,  WOLF DAVID LAWRENCE

IPC: A61K35/58 ,  A61K38/02 ,  A61K38/12 ,  A61K38/17 ,  A61K38/36 ,  A61K38/00 ,  A61K38/57 ,  A61P7/02 ,  C07K1/14 ,  C07K1/20 ,  C07K7/00 ,  C07K7/06 ,  C07K7/64 ,  C07K14/00 ,  C07K14/435 ,  C07K14/46 ,  C07K14/745 ,  C07K14/75 ,  C07K14/755 ,  C07K14/78 ,  C12N1/21 ,  C12N15/09 ,  C12N15/12 ,  C12P21/00 ,  C12P21/02 ,  C12Q1/56 ,  C12R1/19 ,  G01N33/86 ,  A61K38/54 ,  C07K1/00 ,  G01N33/566

Abstract: An assay for screening snake venom for the presence or absence of platelet aggregation inhibitors (PAIs) based on specific receptor binding is described. Using this assay, the identification and characterization of PAIs in a wide range of snake venom samples was accomplished. The isolated and purified PAI from several of these active snake venoms is described and characterized. In addition, PAIs lacking the Arg-Gly-Asp (RGD) adhesion sequence but containing K*-(G/Sar)-D wherein K* is a modified lysyl residue of the formula R 2 N(CH2)4CHNHCO- wherein each R is independently H, alkyl(1-6C) or at most one R is R -C=NR wherein R is H, alkyl(1-6C), phenyl or benzyl, or is NR 2 in which each R is independently H or alkyl(1-6C) and R is H, alkyl(1-6C), phenyl or benzyl, or R -C=NR is a radical selected from the group consisting of: where m is an integer of 2-3, and each R is independently H or alkyl(1-6C); and wherein one or two (CH2) may be replaced by O or S provided said O or S is not adjacent to another heteroatom are prepared and shown to specifically inhibit the binding of fibrinogen or von Willebrand Factor to GP IIb-IIIa.

公开(公告)号：NO982249L

公开(公告)日：1992-01-31

申请号：NO982249

申请日：1998-05-15

Applicant: COR THERAPEUTICS INC

Inventor： SCARBOROUGH ROBERT ,  WOLF DAVID LAWRENCE ,  CHARO ISRAEL F

IPC: A61K35/58 ,  A61K38/00 ,  A61K38/02 ,  A61K38/12 ,  A61K38/17 ,  A61K38/36 ,  A61K38/57 ,  A61P7/02 ,  C07K1/14 ,  C07K1/20 ,  C07K7/00 ,  C07K7/06 ,  C07K7/64 ,  C07K14/00 ,  C07K14/435 ,  C07K14/46 ,  C07K14/745 ,  C07K14/75 ,  C07K14/755 ,  C07K14/78 ,  C12N1/21 ,  C12N15/09 ,  C12N15/12 ,  C12P21/00 ,  C12P21/02 ,  C12Q1/56 ,  C12R1/19 ,  G01N33/86 ,  C07K

Abstract: An assay for screening snake venom for the presence or absence of platelet aggregation inhibitors (PAIs) based on specific receptor binding is described. Using this assay, the identification and characterization of PAIs in a wide range of snake venom samples was accomplished. The isolated and purified PAI from several of these active snake venoms is described and characterized. In addition, PAIs lacking the Arg-Gly-Asp (RGD) adhesion sequence but containing K*-(G/Sar)-D wherein K* is a modified lysyl residue of the formula R 2 N(CH2)4CHNHCO- wherein each R is independently H, alkyl(1-6C) or at most one R is R -C=NR wherein R is H, alkyl(1-6C), phenyl or benzyl, or is NR 2 in which each R is independently H or alkyl(1-6C) and R is H, alkyl(1-6C), phenyl or benzyl, or R -C=NR is a radical selected from the group consisting of: where m is an integer of 2-3, and each R is independently H or alkyl(1-6C); and wherein one or two (CH2) may be replaced by O or S provided said O or S is not adjacent to another heteroatom are prepared and shown to specifically inhibit the binding of fibrinogen or von Willebrand Factor to GP IIb-IIIa.

公开(公告)号：NO914962D0

公开(公告)日：1991-12-16

申请号：NO914962

申请日：1991-12-16

Applicant: COR THERAPEUTICS INC

Inventor： SCARBOROUGH ROBERT M ,  WOLF DAVID LAWRENCE ,  CHARO ISRAEL F

IPC: A61K35/58 ,  A61K38/00 ,  A61K38/02 ,  A61K38/12 ,  A61K38/17 ,  A61K38/36 ,  A61K38/57 ,  A61P7/02 ,  C07K1/14 ,  C07K1/20 ,  C07K7/00 ,  C07K7/06 ,  C07K7/64 ,  C07K14/00 ,  C07K14/435 ,  C07K14/46 ,  C07K14/745 ,  C07K14/75 ,  C07K14/755 ,  C07K14/78 ,  C12N1/21 ,  C12N15/09 ,  C12N15/12 ,  C12P21/00 ,  C12P21/02 ,  C12Q1/56 ,  C12R1/19 ,  G01N33/86 ,  G01N33/00

Abstract: An assay for screening snake venom for the presence or absence of platelet aggregation inhibitors (PAIs) based on specific receptor binding is described. Using this assay, the identification and characterization of PAIs in a wide range of snake venom samples was accomplished. The isolated and purified PAI from several of these active snake venoms is described and characterized. In addition, PAIs lacking the Arg-Gly-Asp (RGD) adhesion sequence but containing K*-(G/Sar)-D wherein K* is a modified lysyl residue of the formula R 2 N(CH2)4CHNHCO- wherein each R is independently H, alkyl(1-6C) or at most one R is R -C=NR wherein R is H, alkyl(1-6C), phenyl or benzyl, or is NR 2 in which each R is independently H or alkyl(1-6C) and R is H, alkyl(1-6C), phenyl or benzyl, or R -C=NR is a radical selected from the group consisting of: where m is an integer of 2-3, and each R is independently H or alkyl(1-6C); and wherein one or two (CH2) may be replaced by O or S provided said O or S is not adjacent to another heteroatom are prepared and shown to specifically inhibit the binding of fibrinogen or von Willebrand Factor to GP IIb-IIIa.

公开(公告)号：NO304267B1

公开(公告)日：1998-11-23

申请号：NO914962

申请日：1991-12-16

Applicant: COR THERAPEUTICS INC

Inventor： SCARBOROUGH ROBERT M ,  WOLF DAVID LAWRENCE ,  CHARO ISRAEL F

IPC: A61K35/58 ,  A61K38/02 ,  A61K38/12 ,  A61K38/17 ,  A61K38/36 ,  A61K38/57 ,  A61K38/00 ,  A61P7/02 ,  C07K1/14 ,  C07K1/20 ,  C07K7/00 ,  C07K7/06 ,  C07K7/64 ,  C07K14/00 ,  C07K14/435 ,  C07K14/46 ,  C07K14/745 ,  C07K14/75 ,  C07K14/755 ,  C07K14/78 ,  C12N1/21 ,  C12N15/09 ,  C12N15/12 ,  C12P21/00 ,  C12P21/02 ,  C12Q1/56 ,  C12R1/19 ,  G01N33/86 ,  C07K14/81 ,  G01N33/566

Abstract: An assay for screening snake venom for the presence or absence of platelet aggregation inhibitors (PAIs) based on specific receptor binding is described. Using this assay, the identification and characterization of PAIs in a wide range of snake venom samples was accomplished. The isolated and purified PAI from several of these active snake venoms is described and characterized. In addition, PAIs lacking the Arg-Gly-Asp (RGD) adhesion sequence but containing K*-(G/Sar)-D wherein K* is a modified lysyl residue of the formula R 2 N(CH2)4CHNHCO- wherein each R is independently H, alkyl(1-6C) or at most one R is R -C=NR wherein R is H, alkyl(1-6C), phenyl or benzyl, or is NR 2 in which each R is independently H or alkyl(1-6C) and R is H, alkyl(1-6C), phenyl or benzyl, or R -C=NR is a radical selected from the group consisting of: where m is an integer of 2-3, and each R is independently H or alkyl(1-6C); and wherein one or two (CH2) may be replaced by O or S provided said O or S is not adjacent to another heteroatom are prepared and shown to specifically inhibit the binding of fibrinogen or von Willebrand Factor to GP IIb-IIIa.

公开(公告)号：NO982249D0

公开(公告)日：1998-05-15

申请号：NO982249

申请日：1998-05-15

Applicant: COR THERAPEUTICS INC

Inventor： SCARBOROUGH ROBERT ,  WOLF DAVID LAWRENCE ,  CHARO ISRAEL F

IPC: A61K35/58 ,  A61K38/00 ,  A61K38/02 ,  A61K38/12 ,  A61K38/17 ,  A61K38/36 ,  A61K38/57 ,  A61P7/02 ,  C07K1/14 ,  C07K1/20 ,  C07K7/00 ,  C07K7/06 ,  C07K7/64 ,  C07K14/00 ,  C07K14/435 ,  C07K14/46 ,  C07K14/745 ,  C07K14/75 ,  C07K14/755 ,  C07K14/78 ,  C12N1/21 ,  C12N15/09 ,  C12N15/12 ,  C12P21/00 ,  C12P21/02 ,  C12Q1/56 ,  C12R1/19 ,  G01N33/86 ,  C07K

Abstract: An assay for screening snake venom for the presence or absence of platelet aggregation inhibitors (PAIs) based on specific receptor binding is described. Using this assay, the identification and characterization of PAIs in a wide range of snake venom samples was accomplished. The isolated and purified PAI from several of these active snake venoms is described and characterized. In addition, PAIs lacking the Arg-Gly-Asp (RGD) adhesion sequence but containing K*-(G/Sar)-D wherein K* is a modified lysyl residue of the formula R 2 N(CH2)4CHNHCO- wherein each R is independently H, alkyl(1-6C) or at most one R is R -C=NR wherein R is H, alkyl(1-6C), phenyl or benzyl, or is NR 2 in which each R is independently H or alkyl(1-6C) and R is H, alkyl(1-6C), phenyl or benzyl, or R -C=NR is a radical selected from the group consisting of: where m is an integer of 2-3, and each R is independently H or alkyl(1-6C); and wherein one or two (CH2) may be replaced by O or S provided said O or S is not adjacent to another heteroatom are prepared and shown to specifically inhibit the binding of fibrinogen or von Willebrand Factor to GP IIb-IIIa.

公开(公告)号：NO914962A

公开(公告)日：1992-01-31

申请号：NO914962

申请日：1991-12-16

Applicant: COR THERAPEUTICS INC

Inventor： SCARBOROUGH ROBERT M ,  WOLF DAVID LAWRENCE ,  CHARO ISRAEL F

IPC: A61K38/00 ,  A61K35/58 ,  A61K38/02 ,  A61K38/12 ,  A61K38/17 ,  A61K38/36 ,  A61K38/57 ,  A61P7/02 ,  C07K1/14 ,  C07K1/20 ,  C07K7/00 ,  C07K7/06 ,  C07K7/64 ,  C07K14/00 ,  C07K14/435 ,  C07K14/46 ,  C07K14/745 ,  C07K14/75 ,  C07K14/755 ,  C07K14/78 ,  C12N1/21 ,  C12N15/09 ,  C12N15/12 ,  C12P21/00 ,  C12P21/02 ,  C12Q1/56 ,  C12R1/19 ,  G01N33/86 ,  A61K37/64 ,  G01N33/566

CPC classification number: C07K14/75 ,  A61K38/12 ,  A61K38/1703 ,  A61K38/57 ,  C07K14/46 ,  C07K14/755 ,  C07K14/78

公开(公告)号：FI915919A0

公开(公告)日：1991-12-16

申请号：FI915919

申请日：1991-12-16

Applicant: COR THERAPEUTICS INC

Inventor： SCARBOROUGH ROBERT M ,  WOLF DAVID LAWRENCE ,  CHARO ISRAEL F

IPC: A61K38/00 ,  A61K35/58 ,  A61K38/02 ,  A61K38/12 ,  A61K38/17 ,  A61K38/36 ,  A61K38/57 ,  A61P7/02 ,  C07K1/14 ,  C07K1/20 ,  C07K7/00 ,  C07K7/06 ,  C07K7/64 ,  C07K14/00 ,  C07K14/435 ,  C07K14/46 ,  C07K14/745 ,  C07K14/75 ,  C07K14/755 ,  C07K14/78 ,  C12N1/21 ,  C12N15/09 ,  C12N15/12 ,  C12P21/00 ,  C12P21/02 ,  C12Q1/56 ,  C12R1/19 ,  G01N33/86 ,  A61K

Abstract: An assay for screening snake venom for the presence or absence of platelet aggregation inhibitors (PAIs) based on specific receptor binding is described. Using this assay, the identification and characterization of PAIs in a wide range of snake venom samples was accomplished. The isolated and purified PAI from several of these active snake venoms is described and characterized. In addition, PAIs lacking the Arg-Gly-Asp (RGD) adhesion sequence but containing K*-(G/Sar)-D wherein K* is a modified lysyl residue of the formula R 2 N(CH2)4CHNHCO- wherein each R is independently H, alkyl(1-6C) or at most one R is R -C=NR wherein R is H, alkyl(1-6C), phenyl or benzyl, or is NR 2 in which each R is independently H or alkyl(1-6C) and R is H, alkyl(1-6C), phenyl or benzyl, or R -C=NR is a radical selected from the group consisting of: where m is an integer of 2-3, and each R is independently H or alkyl(1-6C); and wherein one or two (CH2) may be replaced by O or S provided said O or S is not adjacent to another heteroatom are prepared and shown to specifically inhibit the binding of fibrinogen or von Willebrand Factor to GP IIb-IIIa.

公开(公告)号：DK0477295T3

公开(公告)日：1997-07-07

申请号：DK90911002

申请日：1990-06-15

Applicant: COR THERAPEUTICS INC

Inventor： CHARO ISRAEL F ,  SCARBOROUGH ROBERT M ,  WOLF DAVID LAWRENCE

IPC: A61K38/00 ,  A61K35/58 ,  A61K38/02 ,  A61K38/12 ,  A61K38/17 ,  A61K38/36 ,  A61K38/57 ,  A61P7/02 ,  C07K1/14 ,  C07K1/20 ,  C07K7/00 ,  C07K7/06 ,  C07K7/64 ,  C07K14/00 ,  C07K14/435 ,  C07K14/46 ,  C07K14/745 ,  C07K14/75 ,  C07K14/755 ,  C07K14/78 ,  C12N1/21 ,  C12N15/09 ,  C12N15/12 ,  C12P21/00 ,  C12P21/02 ,  C12Q1/56 ,  C12R1/19 ,  G01N33/86 ,  A61K37/62 ,  C07K1/00 ,  C07K15/00 ,  G01N33/566

Abstract: An assay for screening snake venom for the presence or absence of platelet aggregation inhibitors (PAIs) based on specific receptor binding is described. Using this assay, the identification and characterization of PAIs in a wide range of snake venom samples was accomplished. The isolated and purified PAI from several of these active snake venoms is described and characterized. In addition, PAIs lacking the Arg-Gly-Asp (RGD) adhesion sequence but containing K*-(G/Sar)-D wherein K* is a modified lysyl residue of the formula R 2 N(CH2)4CHNHCO- wherein each R is independently H, alkyl(1-6C) or at most one R is R -C=NR wherein R is H, alkyl(1-6C), phenyl or benzyl, or is NR 2 in which each R is independently H or alkyl(1-6C) and R is H, alkyl(1-6C), phenyl or benzyl, or R -C=NR is a radical selected from the group consisting of: where m is an integer of 2-3, and each R is independently H or alkyl(1-6C); and wherein one or two (CH2) may be replaced by O or S provided said O or S is not adjacent to another heteroatom are prepared and shown to specifically inhibit the binding of fibrinogen or von Willebrand Factor to GP IIb-IIIa.

公开(公告)号：ES2097150T3

公开(公告)日：1997-04-01

申请号：ES90911002

申请日：1990-06-15

Applicant: COR THERAPEUTICS INC

Inventor： SCARBOROUGH ROBERT M ,  WOLF DAVID LAWRENCE ,  CHARO ISRAEL F

IPC: A61K38/00 ,  A61K35/58 ,  A61K38/02 ,  A61K38/12 ,  A61K38/17 ,  A61K38/36 ,  A61K38/57 ,  A61P7/02 ,  C07K1/14 ,  C07K1/20 ,  C07K7/00 ,  C07K7/06 ,  C07K7/64 ,  C07K14/00 ,  C07K14/435 ,  C07K14/46 ,  C07K14/745 ,  C07K14/75 ,  C07K14/755 ,  C07K14/78 ,  C12N1/21 ,  C12N15/09 ,  C12N15/12 ,  C12P21/00 ,  C12P21/02 ,  C12Q1/56 ,  C12R1/19 ,  G01N33/86 ,  A61K38/54 ,  C07K1/00 ,  C07K2/00 ,  G01N33/566

Abstract: An assay for screening snake venom for the presence or absence of platelet aggregation inhibitors (PAIs) based on specific receptor binding is described. Using this assay, the identification and characterization of PAIs in a wide range of snake venom samples was accomplished. The isolated and purified PAI from several of these active snake venoms is described and characterized. In addition, PAIs lacking the Arg-Gly-Asp (RGD) adhesion sequence but containing K*-(G/Sar)-D wherein K* is a modified lysyl residue of the formula R 2 N(CH2)4CHNHCO- wherein each R is independently H, alkyl(1-6C) or at most one R is R -C=NR wherein R is H, alkyl(1-6C), phenyl or benzyl, or is NR 2 in which each R is independently H or alkyl(1-6C) and R is H, alkyl(1-6C), phenyl or benzyl, or R -C=NR is a radical selected from the group consisting of: where m is an integer of 2-3, and each R is independently H or alkyl(1-6C); and wherein one or two (CH2) may be replaced by O or S provided said O or S is not adjacent to another heteroatom are prepared and shown to specifically inhibit the binding of fibrinogen or von Willebrand Factor to GP IIb-IIIa.

公开(公告)号：AT146969T

公开(公告)日：1997-01-15

申请号：AT90911002

申请日：1990-06-15

Applicant: COR THERAPEUTICS INC

Inventor： SCARBOROUGH ROBERT M ,  WOLF DAVID LAWRENCE ,  CHARO ISRAEL F

IPC: A61K38/00 ,  A61K35/58 ,  A61K38/02 ,  A61K38/12 ,  A61K38/17 ,  A61K38/36 ,  A61K38/57 ,  A61P7/02 ,  C07K1/14 ,  C07K1/20 ,  C07K7/00 ,  C07K7/06 ,  C07K7/64 ,  C07K14/00 ,  C07K14/435 ,  C07K14/46 ,  C07K14/745 ,  C07K14/75 ,  C07K14/755 ,  C07K14/78 ,  C12N1/21 ,  C12N15/09 ,  C12N15/12 ,  C12P21/00 ,  C12P21/02 ,  C12Q1/56 ,  C12R1/19 ,  G01N33/86 ,  A61K38/54 ,  C07K1/00 ,  C07K2/00 ,  G01N33/566

Abstract: An assay for screening snake venom for the presence or absence of platelet aggregation inhibitors (PAIs) based on specific receptor binding is described. Using this assay, the identification and characterization of PAIs in a wide range of snake venom samples was accomplished. The isolated and purified PAI from several of these active snake venoms is described and characterized. In addition, PAIs lacking the Arg-Gly-Asp (RGD) adhesion sequence but containing K*-(G/Sar)-D wherein K* is a modified lysyl residue of the formula R 2 N(CH2)4CHNHCO- wherein each R is independently H, alkyl(1-6C) or at most one R is R -C=NR wherein R is H, alkyl(1-6C), phenyl or benzyl, or is NR 2 in which each R is independently H or alkyl(1-6C) and R is H, alkyl(1-6C), phenyl or benzyl, or R -C=NR is a radical selected from the group consisting of: where m is an integer of 2-3, and each R is independently H or alkyl(1-6C); and wherein one or two (CH2) may be replaced by O or S provided said O or S is not adjacent to another heteroatom are prepared and shown to specifically inhibit the binding of fibrinogen or von Willebrand Factor to GP IIb-IIIa.