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公开(公告)号：CA2327664A1
公开(公告)日：1999-11-04
申请号：CA2327664
申请日：1999-04-09
Applicant: CORNING INC
Inventor： DANNOUX THIERRY L A , EID BERNARD , WUSIRIKA RAJO R , CARRE ALAIN R E , ROOT DAVID , BORRELLI NICHOLAS F
IPC: G01N31/22 , B01J4/02 , B01J19/00 , B01L3/00 , B01L3/02 , B01L99/00 , C03B19/06 , C03B23/00 , C03B23/047 , C03B23/06 , C03B37/028 , C40B40/06 , C40B60/14 , C40B70/00 , G01N33/53 , G01N33/543 , G01N35/00 , G01N35/02 , G01N35/10 , G01N37/00
Abstract: Method and apparatus for transferring fluids, especially for use in biologic al testing, includes an array of capillaries (10) having an inlet end (16) and an outled end (18) which is smaller than the inlet end (16). The capillary arra y can be formed by extruding and redrawing a honeycomb pattern of channels. Arrays of different specific binding partners formed using the capillary arr ay are also described.
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公开(公告)号：AU3760499A
公开(公告)日：1999-11-16
申请号：AU3760499
申请日：1999-04-27
Applicant: CORNING INC
Inventor： BORRELLI NICHOLAS F , CARRE ALAIN R E , DANNOUS THIERRY L A , EID BERNARD , ROOT DAVID , WUSIRIKA RAJO R
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公开(公告)号：AU3552499A
公开(公告)日：1999-11-16
申请号：AU3552499
申请日：1999-04-09
Applicant: CORNING INC
Inventor： BORRELLI NICHOLAS F , CARRE ALAIN R E , DANNOUX THIERRY L A , EID BERNARD , ROOT DAVID , WUSIRIKA RAJO R
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公开(公告)号：EP1075327A4
公开(公告)日：2006-01-25
申请号：EP99917389
申请日：1999-04-09
Applicant: CORNING INC
Inventor： BORRELLI NICHOLAS F , CARRE ALAIN R E , DANNOUX THIERRY L A , EID BERNARD , ROOT DAVID , WUSIRIKA RAJO R
IPC: G01N31/22 , B01J4/02 , B01J19/00 , B01L3/00 , B01L3/02 , B01L99/00 , C03B19/06 , C03B23/00 , C03B23/047 , C03B23/06 , C03B37/028 , C40B40/06 , C40B60/14 , C40B70/00 , G01N33/53 , G01N33/543 , G01N35/00 , G01N35/02 , G01N35/10 , G01N37/00 , B01L11/00
CPC classification number: B01L3/02 , B01J4/02 , B01J19/0046 , B01J2219/00274 , B01J2219/0031 , B01J2219/00315 , B01J2219/00317 , B01J2219/00369 , B01J2219/00378 , B01J2219/005 , B01J2219/00511 , B01J2219/00522 , B01J2219/00524 , B01J2219/00547 , B01J2219/00549 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00648 , B01J2219/00659 , B01J2219/00673 , B01J2219/00722 , B01L3/0244 , B01L3/0262 , B01L3/50857 , B01L3/563 , B01L2200/021 , B01L2300/0819 , B01L2300/0838 , B01L2300/0893 , C03B19/06 , C03B23/047 , C03B23/06 , C03B37/028 , C40B40/06 , C40B60/14 , C40B70/00 , G01N33/54306 , G01N35/1065 , G01N35/1067 , G01N2035/00237 , G01N2035/1037 , G01N2035/1069 , Y10T436/2575
Abstract: Methods and apparatus for depositing a high density biological or chemical array onto a solid support. Specifically, the apparatus is made up of a plurality of open ended channels (12) collectively forming a matrix. The matrix has been redrawn and cut such that the pitch of the channels (12) on the loading (16) end is larger than the pitch of the channels on the liquid delivery end (18). The upper portion of each channel serves as a reservoir, while the opposing end, which has been formed by the redrawing process, is diametrically sized such that liquid in the reservoir is retained by capillary pressure at the delivery end. At any point along the height of the capillary reservoir device, all cross-sectional dimensions and areas are uniformly reduced. In other words, the on-center orientation of any two channels, also referred to as the pitch between 2 channels, measured as a function of the diameter of any cross section, is constant throughout the structure. The liquid within the channels is either printed directly from the tool onto a substrate or transferred to a substrate by a typographical pin plate (100). In another embodiment, the device may be used in transferring sample between multiwell plates (66,68) of different well density.
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