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公开(公告)号：US11768194B2
公开(公告)日：2023-09-26
申请号：US17564465
申请日：2021-12-29
Applicant: CORNING INCORPORATED
Inventor： Joshua Monroe Cobb , Gregory Roger Martin , Robert Raymond Raczkowski , Mark Christian Sanson , Horst Schreiber , Todd Michael Upton
CPC classification number: G01N33/4833 , C12M23/12 , C12M41/46 , G01N21/55 , G01N33/5005 , G02B21/361 , G02B21/002 , G02B21/04 , G02B21/36
Abstract: A cell monitoring plate comprises a flat surface on which multiple cell culturing vessels may be stacked. The flats surface has multiple optical imaging systems embedded therein to fully image a cell culture vessels stacked on the plate. Each one of the multiple optical imaging systems provides both illumination and imaging through a single aperture in the surface of the monitoring plate.
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公开(公告)号：US20240360397A1
公开(公告)日：2024-10-31
申请号：US18647679
申请日：2024-04-26
Applicant: CORNING INCORPORATED
Inventor： Ye Fang , Anthony Glenn Frutos , Vasiliy Nikolaevich Goral , Joel Andrew Schultes , Elena Ravilievna Streltsova , Todd Michael Upton , Jennifer Lynn Weber
Abstract: A cell culture bioreactor is disclosed that has a cell culture vessel with an interior reservoir to contain a cell substrate, an inlet fluidly connected to the reservoir, and an outlet fluidly connect to the reservoir. The bioreactor also has a sensor system for measuring impedance within the reservoir. The sensor system includes a pair of electrodes that are spaced apart from each other with at least a portion of the cell substrate disposed between the pair of electrodes. Each electrode of the pair of electrodes includes a plurality of pores to allow at least one of cells and culture media to flow through the electrode.
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Patent Agency Ranking
公开(公告)号：US20220120729A1
公开(公告)日：2022-04-21
申请号：US17564465
申请日：2021-12-29
Applicant: CORNING INCORPORATED
Inventor： Joshua Monroe Cobb , Gregory Roger Martin , Robert Raymond Raczkowski , Mark Christian Sanson , Horst Schreiber , Todd Michael Upton
Abstract: A cell monitoring plate comprises a flat surface on which multiple cell culturing vessels may be stacked. The flats surface has multiple optical imaging systems embedded therein to fully image a cell culture vessels stacked on the plate. Each one of the multiple optical imaging systems provides both illumination and imaging through a single aperture in the surface of the monitoring plate.
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公开(公告)号：US12280368B2
公开(公告)日：2025-04-22
申请号：US17780352
申请日：2020-11-09
Applicant: CORNING INCORPORATED
Inventor： John Wilfred Coddaire , Maryanne De Chambeau , James Thomas Eickmann , Paula Mary Flaherty , Anthony Glenn Frutos , Vasiliy Nikolaevich Goral , Angela Langer Julien , Marshall Jay Kosovsky , Brent Ravaughn Lanterman , Gregory Roger Martin , Christie Leigh McCarthy , John Forrest Roush , John Shyu , Tora Ann-Beatrice Eline Sirkka , Allison Jean Tanner , Kimberly Ann Titus , Todd Michael Upton , Timothy James Wood
Abstract: A connected ecosystem for a laboratory environment comprises an electronic lab notebook, and instrumented biosafety cabinet, and one or more sensing vessels containing cell cultures. The electronic lab notebook interfaces with the instrumented biosafety cabinet to provide instructions, guidance, and monitoring of a user during the set up of the experimental protocol and to receive commands from the user via one of several input modalities. After the experimental protocol has been set up in the instrumented biosafety cabinet, cell cultures may be moved to an incubator where the connected ecosystem may provide automatic monitoring of the cultures. The automatic monitoring is provided by sensors integrated into cell culture vessels and supplemented by images of the cell cultures captured by a camera. The user may be informed of deviations from expected results detected based on the automatic monitoring.
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公开(公告)号：US20230151320A1
公开(公告)日：2023-05-18
申请号：US18099597
申请日：2023-01-20
Applicant: CORNING INCORPORATED
Inventor： Scott Robertson Bickham , Ming-Jun Li , Gregory Roger Martin , Robert Raymond Raczkowski , Horst Schreiber , Todd Michael Upton
Abstract: Methods, systems, and devices for non-invasive measurement of cell cultures are described that provide for remote monitoring of cell status. The system includes a cell culture vessel, at least one monitoring layer, at least one measurement device, and a communication component. The cell culture vessel may include at least one cell culture chamber configured for cell growth and for closed-system operation. The monitoring layer is external to the at least one cell culture chamber. In some cases, the communication component is configured to transmit data from the monitoring layer to a remote location.
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公开(公告)号：US20230007854A1
公开(公告)日：2023-01-12
申请号：US17780352
申请日：2020-11-09
Applicant: CORNING INCORPORATED
Inventor： John Wilfred Coddaire , Maryanne De Chambeau , James Thomas Eickmann , Paula Mary Flaherty , Anthony Glenn Frutos , Vasiliy Nikolaevich Goral , Angela Langer Julien , Marshall Jay Kosovsky , Brent Ravaughn Lanterman , Gregory Roger Martin , Christie Leigh McCarthy , John Forrest Roush , John Shyu , Tora Ann-Beatrice Eline Sirkka , Allison Jean Tanner , Kimberly Ann Titus , Todd Michael Upton , Timothy James Wood
Abstract: A connected ecosystem for a laboratory environment comprises an electronic lab notebook, and instrumented biosafety cabinet, and one or more sensing vessels containing cell cultures. The electronic lab notebook interfaces with the instrumented biosafety cabinet to provide instructions, guidance, and monitoring of a user during the set up of the experimental protocol and to receive commands from the user via one of several input modalities. After the experimental protocol has been set up in the instrumented biosafety cabinet, cell cultures may be moved to an incubator where the connected ecosystem may provide automatic monitoring of the cultures. The automatic monitoring is provided by sensors integrated into cell culture vessels and supplemented by images of the cell cultures captured by a camera. The user may be informed of deviations from expected results detected based on the automatic monitoring.
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公开(公告)号：US20150315536A1
公开(公告)日：2015-11-05
申请号：US14647558
申请日：2013-11-27
Applicant: David Alan KENNEY , Todd Michael TON , Joseph Christopher WALL , CORNING INCORPORATED
Inventor： David Alan Kenney , Todd Michael Upton , Joseph Christopher Wall
Abstract: A flask for the culturing of cells is disclosed. The cell culture chamber is defined by top and bottom walls connected by side and end walls, one end wall shaped such that media can drain to a bottommost spot thereby allowing for the complete removal of media via a vertically oriented pipette inserted into the interior of the flask body through an open neck.
Abstract translation: 公开了一种培养细胞的烧瓶。 细胞培养室由通过侧壁和端壁连接的顶壁和底壁限定，一个端壁成形为使得介质可以排放到最下面的点，从而允许通过插入到内部的内部的垂直取向的移液管完全去除介质 瓶身通过开放的颈部。
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