公开(公告)号：EP0239697B1

公开(公告)日：1992-07-15

申请号：EP86308500.7

申请日：1986-10-31

Applicant: COSTAR CORPORATION

Inventor： Lyman, George F. ,  Root, David ,  Mathus, Gregory

IPC: C12M3/00 ,  C12M1/20

CPC classification number: C12M29/04 ,  C12M25/04

公开(公告)号：EP0237673B1

公开(公告)日：1992-02-26

申请号：EP86308499.2

申请日：1986-10-31

Applicant: COSTAR CORPORATION

Inventor： Mathus, Gregory ,  Lyman, George F. ,  Looney, Kevin

IPC: B01D29/00 ,  B01D35/00

CPC classification number: B01D46/543 ,  B01D29/012 ,  B01D29/05 ,  B01D46/0012 ,  B01D61/18 ,  B01D63/08 ,  B01D2277/20

Abstract: A small volume laboratory filter having a thin rectangular body and coaxial inlet and outlet sleeves connected to opposite ends thereof. A very thin filter cavity is formed in the body and lies in a plane inclined slightly to the common axis of the inlet and outlet sleeves. The cavity is divided by a filter membrane into extremely thin chambers, one communicating with the inlet sleeve and the other with the outlet sleeve. A rigid package for the filter is sealed across one end by a flexible cover which when stripped from the package exposes the inlet sleeve so that it may be readily engaged by a syringe nipple or other fluid source without the user having to touch the filter. When the inlet sleeve is engaged, the filter may be withdrawn from the package.

公开(公告)号：EP0797088B1

公开(公告)日：2000-05-31

申请号：EP97301686.8

申请日：1997-03-13

Applicant: Corning Costar Corporation

Inventor： Mathus, Gregory ,  Szlosek R.R., Paul M. ,  Lacey, William J.

IPC: G01N21/25 ,  B01L3/00 ,  G01N21/03

CPC classification number: B01L3/5085 ,  B01L2300/0829 ,  B01L2300/12 ,  B29C45/1418 ,  B29C45/14344 ,  B29C45/14778 ,  G01N21/03 ,  G01N21/25 ,  G01N21/33

公开(公告)号：EP0237673A3

公开(公告)日：1988-03-30

申请号：EP86308499

申请日：1986-10-31

Applicant: COSTAR CORPORATION

Inventor： Mathus, Gregory ,  Lyman, George F. ,  Looney, Kevin

IPC: B01D29/00 ,  B01D35/00

CPC classification number: B01D46/543 ,  B01D29/012 ,  B01D29/05 ,  B01D46/0012 ,  B01D61/18 ,  B01D63/08 ,  B01D2277/20

Abstract: A small volume laboratory filter having a thin rectangular body and coaxial inlet and outlet sleeves connected to opposite ends thereof. A very thin filter cavity is formed in the body and lies in a plane inclined slightly to the common axis of the inlet and outlet sleeves. The cavity is divided by a filter membrane into extremely thin chambers, one communicating with the inlet sleeve and the other with the outlet sleeve. A rigid package for the filter is sealed across one end by a flexible cover which when stripped from the package exposes the inlet sleeve so that it may be readily engaged by a syringe nipple or other fluid source without the user having to touch the filter. When the inlet sleeve is engaged, the filter may be withdrawn from the package.

公开(公告)号：EP0237673A2

公开(公告)日：1987-09-23

申请号：EP86308499.2

申请日：1986-10-31

Applicant: COSTAR CORPORATION

Inventor： Mathus, Gregory ,  Lyman, George F. ,  Looney, Kevin

IPC: B01D29/00 ,  B01D35/00

CPC classification number: B01D46/543 ,  B01D29/012 ,  B01D29/05 ,  B01D46/0012 ,  B01D61/18 ,  B01D63/08 ,  B01D2277/20

Abstract: A small volume laboratory filter having a thin rectangular body and coaxial inlet and outlet sleeves connected to opposite ends thereof. A very thin filter cavity is formed in the body and lies in a plane inclined slightly to the common axis of the inlet and outlet sleeves. The cavity is divided by a filter membrane into extremely thin chambers, one communicating with the inlet sleeve and the other with the outlet sleeve.
A rigid package for the filter is sealed across one end by a flexible cover which when stripped from the package exposes the inlet sleeve so that it may be readily engaged by a syringe nipple or other fluid source without the user having to touch the filter. When the inlet sleeve is engaged, the filter may be withdrawn from the package.

公开(公告)号：EP0265028A3

公开(公告)日：1989-08-30

申请号：EP87300898.1

申请日：1987-02-02

Applicant: COSTAR CORPORATION

Inventor： Lyman, George ,  Mathus, Gregory

IPC: B01L3/02

CPC classification number: B01L3/0224 ,  G01N35/1065 ,  Y10S436/809

Abstract: A multi-channel pipetter has a U-shaped housing with horizontal upper and lower arms and an interconnecting hand grip portion. A plurality of nozzles that serve to support replaceable tips are mounted on the lower arm in a vertical orientation are connected by a flexible tubing that extends upwardly through the grip portion to a circular array of cylinders disposed horizontally in the upper arm. A piston- cylinder-volume setting mechanism is horizontally disposed in the upper arm. The mechanism is actuated by a trigger on the hand grip portion and the volume is controlled by a micrometer head which operates a stop within the upper arm. A tip ejector is mounted in the lower arm which provides substantial mechanical advantage for stripping the tips from the nozzles.

公开(公告)号：EP0265028A2

公开(公告)日：1988-04-27

申请号：EP87300898.1

申请日：1987-02-02

Applicant: COSTAR CORPORATION

Inventor： Lyman, George ,  Mathus, Gregory

IPC: B01L3/02

CPC classification number: B01L3/0224 ,  G01N35/1065 ,  Y10S436/809

Abstract: A multi-channel pipetter has a U-shaped housing with horizontal upper and lower arms and an interconnecting hand grip portion. A plurality of nozzles that serve to support replaceable tips are mounted on the lower arm in a vertical orientation are connected by a flexible tubing that extends upwardly through the grip portion to a circular array of cylinders disposed horizontally in the upper arm. A piston- cylinder-volume setting mechanism is horizontally disposed in the upper arm. The mechanism is actuated by a trigger on the hand grip portion and the volume is controlled by a micrometer head which operates a stop within the upper arm. A tip ejector is mounted in the lower arm which provides substantial mechanical advantage for stripping the tips from the nozzles.

Abstract translation: 多通道移液器具有U型壳体，其具有水平上臂和下臂以及互连的手柄部分。 用于支撑可更换尖端的多个喷嘴以垂直方向安装在下臂上，该柔性管通过把手部分向上延伸到水平放置在上臂中的圆柱形圆形阵列。 在上臂中水平设置有活塞缸体积设定机构。 该机构由手握部分上的触发器致动，并且该体积由在上臂中操作停止的测微头来控制。 尖端喷射器安装在下臂中，其为从喷嘴剥离尖端提供了实质的机械优点。

公开(公告)号：EP0797088A1

公开(公告)日：1997-09-24

申请号：EP97301686.8

申请日：1997-03-13

Applicant: Corning Costar Corporation

Inventor： Mathus, Gregory ,  Szlosek R.R., Paul M. ,  Lacey, William J.

IPC: G01N21/25 ,  B01L3/00 ,  G01N21/03

CPC classification number: B01L3/5085 ,  B01L2300/0829 ,  B01L2300/12 ,  B29C45/1418 ,  B29C45/14344 ,  B29C45/14778 ,  G01N21/03 ,  G01N21/25 ,  G01N21/33

Abstract: Microplates and methods for manufacturing microplates. The microplate is designed to allow UV radiation to pass through the bottom wells of the microplate so that the microplate can be used for assaying samples by use of UV absorbance. In one embodiment, the microplate comprises at least first and second wells, each well having a UV permeable bottom. In another embodiment, the microplate comprises a frame having an upper portion and a lower portion contiguous with the upper portion and a sheet disposed between the upper portion and the lower portion and defining the bottom of at least one well of the microplate. One embodiment of the method includes steps of inserting a sheet of UV permeable material into a mold cavity that includes sections shaped to form the sidewalls of the plurality of wells, injecting molten plastic material into the mold cavity, and cooling the plastic material to form the microplate with the plastic material forming the sidewalls of each of the first and second wells and the sheet of UV permeable material forming the bottom of each of the first and second wells. Another embodiment of the method includes providing an upper plate defining sidewalls of at least one well, adhering an intermediate layer to the upper plate and adhering a sheet of UV permeable material to the intermediate layer. A further embodiment of the method includes inserting a sheet of material having at least one hole into a mold cavity, injecting a molten plastic material into the mold cavity and cooling the plastic material to form a microplate.

Abstract translation: 微孔板和微孔板制造方法。 微孔板被设计成允许UV辐射通过微板的底部孔，使得微孔板可以用于通过使用UV吸光度来测定样品。 在一个实施方案中，微孔板包括至少第一和第二孔，每个孔具有可UV透过的底部。 在另一个实施例中，微板包括具有上部和与上部相邻的下部的框架，以及设置在上部和下部之间并限定微板的至少一个孔的底部的框架。 该方法的一个实施方案包括以下步骤：将一片UV可渗透材料插入到模腔中，该模腔包括成形为形成多个孔的侧壁的部分，将熔融的塑料材料注入模腔中，并且冷却塑料材料以形成 微孔板，其中塑料材料形成第一和第二孔中的每一个的侧壁，以及形成第一和第二孔中的每一个的底部的UV可渗透材料片。 该方法的另一实施例包括提供限定至少一个阱的侧壁的上板，将中间层粘附到上板并将一片UV可渗透材料粘合到中间层。 该方法的另一实施例包括将具有至少一个孔的材料片插入模腔中，将熔融的塑料材料注入模腔并冷却塑料材料以形成微板。

公开(公告)号：EP0265028B1

公开(公告)日：1992-09-16

申请号：EP87300898.1

申请日：1987-02-02

Applicant: COSTAR CORPORATION

Inventor： Lyman, George ,  Mathus, Gregory

IPC: B01L3/02

CPC classification number: B01L3/0224 ,  G01N35/1065 ,  Y10S436/809

公开(公告)号：EP0237674A3

公开(公告)日：1988-08-03

申请号：EP86308501

申请日：1986-10-31

Applicant: COSTAR CORPORATION

Inventor： Lyman, George F. ,  Mathus, Gregory

IPC: B01L03/14 ,  B04B05/04

CPC classification number: B01L3/5021 ,  B01D33/15 ,  B01D2201/285 ,  B04B5/0414

Abstract: A filter for a centrifuge tube including a pressure filter (18) for separating a mixture under centrifugal force. The filter tube (10) is adapted to fit within the upper portion of a standard plastic centrifuge tube (51). The filter tube (10) has a pressure filter (18) at its lower end and an opening (14) at its upper end adapted to be sealed by a cap (55) extending from the centrifuge tube to hold the filter tube (10) securely in position within the centrifuge tube (51). The filter tube (10) is filled with a mixture of permeable and non-permeable materials and when the composite centrifuge tube (51) and filter tube (10) is spun in the centrifuge, the centrifugal force causes the permeable materials to flow through the filter (18) and collect in the bottom (52) of the centrifuge tube (51) while the non-permeable materials are retained in the filter tube (10).

Abstract translation: 一种用于离心管的过滤器，包括用于在离心力下分离混合物的压力过滤器。 过滤管适于装配在标准塑料离心管的上部。 过滤管在其下端具有压力过滤器，其上端的开口适于由从离心管延伸的盖密封以将过滤管牢固地固定在离心管内的适当位置。 过滤管填充有可渗透和不可渗透的材料的混合物，当复合离心管和过滤管在离心机中旋转时，离心力使渗透材料流过过滤器并收集在离心机的底部 而不透气材料保留在过滤管中。