公开(公告)号：WO2014057424A3

公开(公告)日：2014-10-16

申请号：PCT/IB2013059211

申请日：2013-10-08

Applicant: CSIR

Inventor： LAND KEVIN JOHN ,  MBANJWA MESULI BONANI

IPC: B01J2/06 ,  B01J2/08 ,  C12N9/96 ,  C12N9/98 ,  C12N11/06 ,  C12N11/08

CPC classification number: B01J2/06 ,  B01J2/08 ,  C12N9/96 ,  C12N9/98 ,  C12N11/02

Abstract: A process for producing product particles includes producing, by means of a droplet-based microfluidic technique, a plurality of primary droplets of a first liquid phase dispersed in a continuous second liquid phase. The first liquid phase is immiscible with the second liquid phase. An emulsion of the primary droplets in the second liquid phase is formed. A liquid adjunct is admixed with the emulsion. The liquid adjunct comprises secondary droplets of a third liquid phase, and/or particles, dispersed in a fourth liquid phase. The third liquid phase and/or the particles and/or the fourth liquid phase include a reagent capable of reacting with a component of the first liquid phase. The secondary droplets and/or the particles (whichever is/are present) are smaller than the primary droplets. The secondary droplets are allowed to coalesce with the primary droplets, and/or the particles are allowed to mix with primary droplets, thereby to form tertiary droplets. In the tertiary droplets, the reagent is allowed to react with the component of the first liquid phase, so that product particles are formed from the tertiary droplets. The product particles are recovered from the second liquid phase.

Abstract translation: 用于生产产品颗粒的方法包括通过基于液滴的微流体技术制备分散在连续的第二液相中的第一液相的多个初级液滴。 第一液相与第二液相不混溶。 在第二液相中形成初级液滴的乳液。 液体助剂与乳液混合。 液体助剂包括分散在第四液相中的第三液相和/或颗粒的二次液滴。 第三液相和/或颗粒和/或第四液相包括能够与第一液相的组分反应的试剂。 次级液滴和/或颗粒（以存在的数量为准）小于初级液滴。 允许二次液滴与主液滴聚结，和/或允许颗粒与初级液滴混合，从而形成三次液滴。 在第三液滴中，允许试剂与第一液相的组分反应，使得产物颗粒由第三液滴形成。 产物颗粒从第二液相中回收。

公开(公告)号：ZA201502519B

公开(公告)日：2016-01-27

申请号：ZA201502519

申请日：2015-04-14

Applicant: CSIR

Inventor： MBANJWA MESULI BONANI ,  LAND KEVIN JOHN