Abstract:
Fluid filtration devices that include nylon membranes are provided according to the present disclosure that maintain thorough wetting of a membrane through the end cap bonding process. The fluid filtration device typically includes a pleated microporous nylon filter media and polypropylene end caps. The pleated microporous filter media is treated with hydrophilic polymeric surface treatments at the ends thereof prior to contact with molten polypropylene end caps, thereby maintaining the ability to integrity test the filtration device in water. Exemplary polymeric surface treatments include solutions and dispersions of polyvinyl alcohol, polyethyleneimine, a combination of 1-4 butanediol diglycidyl ether and ethylene amine, and a quaternary amine polyepichlorohydrin.
Abstract:
Fluid filtration devices that include nylon membranes are provided according to the present disclosure that maintain thorough wetting of a membrane through the end cap bonding process. The fluid filtration device typically includes a pleated microporous nylon filter media and polypropylene end caps. The pleated microporous media is treated with hydrophilic polymeric surface treatments at the ends thereof prior to contact with molten polypropylene end caps, thereby maintaining the ability to integrity test the filtration device in water. Exemplary polymeric surface treatments include solutions and dispersions of polyvinyl alcohol, polyethyleneimine, a combination of 1-4 butanediol diglycidyl ether and ethylene amine, and a quaternary amine polyepichlorohydrin.
Abstract:
A filter element (12) is disclosed that includes a filtration media (18), an upstream pleat support (16) and a multi-layer downstream pleat support. The multi-layer downstream support includes a first downstream support layer (19) and a second downstream support layer (22). The first downstream support layer is in contact with the filtration media and is interposed between the filtration media and the second downstream layer. The first downstream support layer is fabricated so as to minimize points of surface contact with the filtration media, thereby enhancing fluid flow away from the filtration media. The second downstream support layer is in contact with the first downstream support layer and is fabricated so as to facilitate lateral fluid flow relative to the multi-layer downstream pleat support. The disclosed filter element may be utilized in filter cartridges of various designs to provide enhanced filtration performance, e.g., by way of increased media area and improved flow/throughput.
Abstract:
A fluid filtration device is disclosed which includes a capsule housing having an upper housing portion defining an axial fluid inlet and a lower housing portion defining an axial fluid outlet, a filter assembly including an elongated mounting post and a plurality of filtration cells supported on the mounting post in axially spaced apart relationship, and structure operatively associated with the mounting post and the lower housing portion for effectuating axial compression of the filtration cells relative to the mounting post when the mounting post is engaged in the lower housing portion during assembly.
Abstract:
Phase inversion microporous membranes including at least two different pore size regions are provided, wherein two membrane sheets are placed, back-to-back, such that the qualifying pore zones are positioned internally within the structure. Exemplary membranes according to the present disclosure provide excellent thermal stability and retention characteristics. Methods for fabricating and using the disclosed membrane structures are also provided according to the present disclosure.
Abstract:
Phase inversion microporous membranes including at least two different pore size regions are provided, wherein two membrane sheets are placed, back-to-back, such that the qualifying pore zones are positioned internally within the structure. Exemplary membranes according to the present disclosure provide excellent thermal stability and retention characteristics. Methods for fabricating and using the disclosed membrane structures are also provided according to the present disclosure.
Abstract:
A method for retrieving excess pharmaceutical process fluid from the hold-up volume of a primary fluid filtration device. The hold-up volume is the volume of excess process fluid which accumulates in the bottom of the filter housing below the outlet opening thereof. Because it is considered valuable, the excess pharmaceutical process fluid is retrieved from the lower housing (22) via a drainage port (23) formed therein below the level of the outlet. The excess process fluid is then filtered in a supplemental filtration device (100) that is connected to the drainage port. The supplemental filtration device has a smaller volumetric capacity than the capacity of the primary fluid filtration device.
Abstract:
Phase inversion microporous membranes including at least two different pore size regions are provided, wherein two membrane sheets are placed, back-to-back, such that the qualifying pore zones are positioned internally within the structure. Exemplary membranes according to the present disclosure provide excellent thermal stability and retention characteristics. Methods for fabricating and using the disclosed membrane structures are also provided according to the present disclosure.
Abstract:
Fluid filtration devices that include nylon membranes are provided according to the present disclosure that maintain thorough wetting of a membrane through the end cap bonding process. The fluid filtration device typically includes a pleated microporous nylon filter media and polypropylene end caps. The pleated microporous filter media is treated with hydrophilic polymeric surface treatments at the ends thereof prior to contact with molten polypropylene end caps, thereby maintaining the ability to integrity test the filtration device in water. Exemplary polymeric surface treatments include solutions and dispersions of polyvinyl alcohol, polyethyleneimine, a combination of 1-4 butanediol diglycidyl ether and ethylene amine, and a quaternary amine polyepichlorohydrin.
Abstract:
A method for retrieving excess pharmaceutical process fluid from the hold-up volume of a primary fluid filtration device. The hold-up volume is the volume of excess process fluid which accumulates in the bottom of the filter housing below the outlet opening thereof. Because it is considered valuable, the excess pharmaceutical process fluid is retrieved from the lower housing (22) via a drainage port (23) formed therein below the level of the outlet. The excess process fluid is then filtered in a supplemental filtration device (100) that is connected to the drainage port. The supplemental filtration device has a smaller volumetric capacity than the capacity of the primary fluid filtration device.