公开(公告)号：CA3115831A1

公开(公告)日：2020-07-30

申请号：CA3115831

申请日：2019-12-02

Applicant: CYTOSORBENTS CORP

Inventor： GULIASHVILI TAMAZ ,  GRUDA MARYANN ,  GOLOBISH THOMAS ,  JAMES DAVID ,  RUGGEBERG KARL-GUSTAV ,  O'SULLIVAN PAM ,  PATTERSON SARAH

IPC: C07K16/06 ,  B01D15/38 ,  C07K16/34 ,  G01N33/80

Abstract: The invention concerns polymeric media based on modified natural polysaccharides for removing one or both of Anti-A Antibodies and Anti-B Antibodies from human blood or plasma, the media comprising one or both of (i) a polymeric solid support with a blood group A Antigen ligand attached to the solid support at a ligand loading between 1 5 mg/mL of solid support, and wherein the media is stable under physiological pH conditions, and (ii) a polymeric solid support with a blood group B Antigen ligand attached to the solid support at a ligand loading between 1 5 mg/mL of solid support, and wherein the media is stable under physiological pH conditions.