公开(公告)号：CA2729340C

公开(公告)日：2017-07-11

申请号：CA2729340

申请日：2009-06-26

Applicant: CYTOSORBENTS INC

Inventor： WINCHESTER JAMES F ,  YOUNG WEI-TAI ,  CAPPONI VINCENT J

IPC: A61M1/38 ,  A61M1/36 ,  B01D15/00 ,  B01J20/26 ,  C08F2/20 ,  C08J9/00

Abstract: A polymer sorbent clears myoglobin from blood and/or other physiological fluids and solutions. Normal saline or human serum in which myoglobin was dissolved is perfused by a peristaltic pump through a column packed with the polymer sorbent. After a four-hour perfusion, the myoglobin level in normal saline fell from initial levels to virtually undetectable levels. Perfusion through the polymer sorbent was then found to lower concentrations of dissolved myoglobin to a significant degree in samples of human serum after four hours, indicating that the polymer sorbent is an effective sorbent for myoglobin.

公开(公告)号：CA2729340A1

公开(公告)日：2009-12-30

申请号：CA2729340

申请日：2009-06-26

Applicant: CYTOSORBENTS INC

Inventor： WINCHESTER JAMES F ,  YOUNG WEI-TAI ,  CAPPONI VINCENT J

IPC: B01D71/16

Abstract: A polymer sorbent clears myoglobin from blood and/or other physiological fluids and solutions. Normal saline or human serum in which myoglobin was dissolved is perfused by a peristaltic pump through a column packed with the polymer sorbent. After a four-hour perfusion, the myoglobin level in normal saline fell from initial levels to virtually undetectable levels. Perfusion through the polymer sorbent was then found to lower concentrations of dissolved myoglobin to a significant degree in samples of human serum after four hours, indicating that the polymer sorbent is an effective sorbent for myoglobin.

公开(公告)号：EP2303441A4

公开(公告)日：2016-06-15

申请号：EP09770565

申请日：2009-06-26

Applicant: CYTOSORBENTS INC

Inventor： WINCHESTER JAMES F ,  YOUNG WEI-TAI ,  CAPPONI VINCENT J

IPC: B01D71/16 ,  A61M1/36 ,  B01J20/26

CPC classification number: A61M1/3679 ,  B01J20/264

Abstract: A polymer sorbent clears myoglobin from blood and/or other physiological fluids and solutions. Normal saline or human serum in which myoglobin was dissolved is perfused by a peristaltic pump through a column packed with the polymer sorbent. After a four-hour perfusion, the myoglobin level in normal saline fell from initial levels to virtually undetectable levels. Perfusion through the polymer sorbent was then found to lower concentrations of dissolved myoglobin to a significant degree in samples of human serum after four hours, indicating that the polymer sorbent is an effective sorbent for myoglobin.

公开(公告)号：EP2661367A4

公开(公告)日：2017-03-08

申请号：EP12732362

申请日：2012-01-06

Applicant: CYTOSORBENTS INC

Inventor： CHAN PHILLIP P ,  CAPPONI VINCENT J ,  GOLOBISH THOMAS D ,  ALI HUMAYRA BEGUM

IPC: B01J20/26 ,  A61M1/36 ,  B01J20/32 ,  C08F8/00

CPC classification number: A61M1/3679 ,  B01J20/267 ,  B01J20/28019 ,  B01J20/3208 ,  B01J20/3248 ,  B01J20/3285 ,  C08F8/00

Abstract: The invention concerns polymer systems comprising at least one polymer with a plurality of pores where the polymer is initially functionalized on substantially all surfaces followed by a stepwise surface specific functionalization such that a different functional group resides on the external or internal pore surface of the bead. The invention also concerns use of such polymer systems in blood, blood product, or physiologic fluid purification.

公开(公告)号：EP2552459A4

公开(公告)日：2013-12-25

申请号：EP11763501

申请日：2011-04-01

Applicant: CYTOSORBENTS INC

Inventor： CHAN PHILLIP P ,  YOUNG WEI-TAI ,  CAPPONI VINCENT J ,  GOLOBISH THOMAS D ,  BARLETT ROBERT H

IPC: A61K31/74 ,  A61K31/75 ,  A61P29/00

CPC classification number: A61K31/745 ,  A61K9/0053 ,  A61K9/16 ,  A61K9/50 ,  A61K31/74 ,  A61K31/75 ,  A61K47/58 ,  B01J20/261 ,  B01J20/28004 ,  B01J20/28073 ,  B01J20/28076 ,  B01J20/3064 ,  C08F212/36 ,  C08J9/26 ,  C08J2201/0444 ,  C08J2207/10 ,  C08J2325/02

Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.

Abstract translation: 本发明涉及治疗患有炎症或有发生炎症风险的患者的系统性，区域性或局部炎症的方法，其包括施用治疗有效剂量的吸着所述患者中的炎性介质的吸着剂。 在一些优选的实施方案中，吸附剂是生物相容性有机聚合物。