公开(公告)号：US20020177710A1

公开(公告)日：2002-11-28

申请号：US10017489

申请日：2001-12-14

Applicant: California Institute Technology; Cymetech, LLC

Inventor： Robert H. Grubbs ,  Jennifer A. Love ,  Melanie S. Sanford ,  Tina M. Trnka ,  Jason L. Moore

IPC: C07F015/00

CPC classification number: C08G61/06 ,  B01J31/181 ,  B01J31/1815 ,  B01J31/182 ,  B01J31/1825 ,  B01J31/183 ,  B01J31/2273 ,  B01J2231/14 ,  B01J2231/543 ,  B01J2531/821 ,  B01J2531/825 ,  C07C6/04 ,  C07C6/06 ,  C07C2531/22 ,  C07F15/002 ,  C07F15/0046

Abstract: The present invention relates to novel hexacoordinated metathesis catalysts and to methods for making and using the same. The inventive catalysts are of the formula 1 wherein: M is ruthenium or osmium; X and X1 are the same or different and are each independently an anionic ligand; L, L1null and L2 are the same or different and are each independently a neutral electron donor ligand, wherein at least one L, L1null and L2 is an N-heterocyclic carbene ligand; and, R and R1 are each independently hydrogen or a substituent selected from the group consisting of C1-C20 alkyl, C2-C20 alkenyl, C2-C20 alkynyl, aryl, C1-C20 carboxylate, C1-C20 alkoxy, C2-C20 alkenyloxy, C2-C20 alkynyloxy, aryloxy, C2-C20 alkoxycarbonyl, C1-C20 alkylthio, C1-C20 alkylsulfonyl and C1-C20 alkylsulfinyl. Optionally, each of the R or R1 substituent group may be substituted with one or more moieties selected from the group consisting of C1-C10 alkyl, C1-C10 alkoxy, and aryl which in turn may each be further substituted with one or more groups selected from a halogen, a C1-C5 alkyl, C1-C5 alkoxy, and phenyl. Moreover, any of the catalyst ligands may further include one or more functional groups. Examples of suitable functional groups include but are not limited to: hydroxyl, thiol, thioether, ketone, aldehyde, ester, ether, amine, imine, amide, nitro, carboxylic acid, disulfide, carbonate, isocyanate, carbodiimide, carboalkoxy, carbamate, and halogen.

Abstract translation: 本发明涉及新型六配位复分解催化剂及其制备和使用方法。 本发明的催化剂具有下式：其中：M是钌或锇; X和X 1相同或不同，各自独立地为阴离子配体; L，L1'和L2相同或不同，各自独立地为中性电子给体配体，其中至少一个L，L1'和L2为N-杂环卡宾配体; 和R 1和R 2各自独立地为氢或选自C 1 -C 20烷基，C 2 -C 20烯基，C 2 -C 20炔基，芳基，C 1 -C 20羧酸酯，C 1 -C 20烷氧基，C 2 -C 20链烯氧基， C 2 -C 20炔氧基，芳氧基，C 2 -C 20烷氧基羰基，C 1 -C 20烷硫基，C 1 -C 20烷基磺酰基和C 1 -C 20烷基亚磺酰基。 任选地，R或R ​​1取代基中的每一个可以被一个或多个选自C 1 -C 10烷基，C 1 -C 10烷氧基和芳基的部分取代，所述基团又可以进一步被选出的一个或多个基团取代 卤素，C 1 -C 5烷基，C 1 -C 5烷氧基和苯基。 此外，任何催化剂配体还可以包括一个或多个官能团。 合适的官能团的实例包括但不限于羟基，硫醇，硫醚，酮，醛，酯，醚，胺，亚胺，酰胺，硝基，羧酸，二硫化物，碳酸酯，异氰酸酯，碳二亚胺，碳烷氧基，氨基甲酸酯和 卤素。