公开(公告)号：WO2020032595A1

公开(公告)日：2020-02-13

申请号：PCT/KR2019/009917

申请日：2019-08-07

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： LEE, Ji Sun ,  CHANG, Dong Eun ,  KIM, Sang Jun ,  KIM, So Young

IPC: C12N15/69 ,  C12N15/70 ,  C12N9/12

Abstract: A nucleic acid molecule comprising a variant inc coding strand is disclosed as a regulator of plasmid copy number. Also disclosed is a replicon comprising the nucleic acid molecule, a promoter, and an origin of replication. Also disclosed is a vector comprising the replicon. Also disclosed is a recombinant microorganism comprising the vector.

公开(公告)号：WO2020032590A1

公开(公告)日：2020-02-13

申请号：PCT/KR2019/009909

申请日：2019-08-07

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： LEE, Ji Sun ,  CHANG, Dong Eun ,  KIM, So Young

IPC: C12N15/63 ,  C12N15/70 ,  C12N9/12

Abstract: A nucleic acid molecule comprising a variant rpoC coding sequence is disclosed. The variant rpoC coding sequence encodes a variant RpoC which regulates copy number of a plasmid. Also disclosed are a recombinant microorganism comprising the nucleic acid molecule, a method for regulating copy number of a subject vector in the recombinant microorganism, and a method for making a target product by use of the recombinant microorganism.

公开(公告)号：EP4349981A1

公开(公告)日：2024-04-10

申请号：EP22911915.1

申请日：2022-12-21

Applicant: CJ Cheiljedang Corporation

Inventor： SEOK, Jooyeon ,  CHOI, Su Jin ,  HONG, Eunsoo ,  LEE, Ji Sun

IPC: C12N9/88 ,  C12N15/52 ,  C12P7/62 ,  C12N15/70

Abstract: Provided are a mutant gene encoding phosphoenolpyruvate carboxylase including a mutant 5'-untranslated region (5'UTR), a polyhydroxyalkanoate (PHA)-producing microorganism including the gene, and a method of producing PHA using the microorganism.

公开(公告)号：EP3119875B1

公开(公告)日：2019-02-27

申请号：EP15765883.2

申请日：2015-03-17

Applicant: CJ Cheiljedang Corporation

Inventor： LEE, Ji Sun ,  SEO, Chang Il ,  CHEONG, Ki Yong ,  KOH, Eun Sung ,  KWON, Do Hyun ,  LEE, Kwang Ho

IPC: C12N15/70 ,  C07K14/245 ,  C12P13/08 ,  C12P13/22

公开(公告)号：EP2233570A1

公开(公告)日：2010-09-29

申请号：EP09700769.4

申请日：2009-01-07

Applicant: CJ CheilJedang Corporation

Inventor： LEE, Kwang Ho ,  JU, Jae Yeong ,  LEE, Ji Sun ,  HWANG, Young Bin ,  JHON, Sung Hoo ,  KOH, Eun Sung ,  KIM, Chul Ha ,  SHIN, Soo An

IPC: C12N15/04

CPC classification number: C12P13/08 ,  C12N9/1085 ,  C12N9/88

Abstract: An L-threonine-producing Escherichia coli in which a promoter of a phosphoenolpyruvate carboxylase (ppc) gene on the chromosome is substituted with a promoter of a cysteine synthase ( cysk ) gene and a method of producing L-threonine by using the same are disclosed. The recombinant Escherichia coli may produce L-threonine in a high yield, and thus may be widely used in medical, pharmaceutical, and feed industries, particularly for an animal feed.

Abstract translation: 公开了其中染色体上的磷酸烯醇丙酮酸羧化酶（ppc）基因的启动子被半胱氨酸合成酶（cysk）基因的启动子取代的产生L-苏氨酸的大肠杆菌和使用该L-赖氨酸的L-苏氨酸的生产方法 。 重组大肠杆菌可以以高产率生产L-苏氨酸，因此可广泛用于医药，制药和饲料工业，尤其用于动物饲料。

公开(公告)号：EP3144385B1

公开(公告)日：2020-08-12

申请号：EP15837846.3

申请日：2015-09-04

Applicant: CJ Cheiljedang Corporation

Inventor： LEE, Ji Sun ,  LEE, Kwang Ho ,  KIM, Hyo Jin ,  LEE, Keun Chul ,  HWANG, Young Bin

IPC: C12N9/12 ,  C12N15/54 ,  C12P13/08 ,  C07K14/245

公开(公告)号：EP3597738A1

公开(公告)日：2020-01-22

申请号：EP19742120.9

申请日：2019-05-21

Applicant: CJ Cheiljedang Corporation

Inventor： KIM, Hyo Jin ,  HUR, Lan ,  LIM, Sang Jo ,  KIM, Hyun Ah ,  KIM, Hyung Joon ,  SEO, Chang Il ,  LEE, Seung Bin ,  LEE, Ji Sun

IPC: C12N9/04 ,  C12N15/52 ,  C12N15/77 ,  C12P13/06 ,  C12P13/08 ,  C12P13/12

Abstract: The present disclosure relates to modified homoserine dehydrogenase and a method for producing a homoserine-derived L-amino acid using the same.

公开(公告)号：EP3015547B1

公开(公告)日：2018-10-03

申请号：EP14818556.4

申请日：2014-04-24

Applicant: CJ Cheiljedang Corporation

Inventor： LEE, Ji Sun ,  LEE, Kwang Ho ,  KOH, Eun Sung ,  KIM, Hyung Joon ,  LEE, Keun Cheol ,  HWANG, Young Bin

IPC: C12N9/12 ,  C12N15/54 ,  C12N15/70 ,  C12P13/08

CPC classification number: C12N9/1247 ,  C07K14/245 ,  C12N15/70 ,  C12P13/08 ,  C12Y207/07006

Abstract: The present application relates to an L-threonine-producing microorganism and a production method for L-threonine using the same, and more specifically, to a microorganism having enhanced L-threonine productivity and a method for producing L-threonine in high yield using the same.

公开(公告)号：EP3106516A1

公开(公告)日：2016-12-21

申请号：EP14882402.2

申请日：2014-04-25

Applicant: CJ Cheiljedang Corporation

Inventor： KIM, Hyung Joon ,  KWON, Su Yon ,  KOH, Eun Sung ,  LEE, Ji Sun ,  LEE, Keun Cheol ,  HWANG, Young Bin ,  HONG, Hyeong Pyo

IPC: C12N1/21 ,  C12N15/52 ,  C12P13/08

CPC classification number: C12P13/08 ,  C07K14/34 ,  C12N15/52

Abstract: The present invention relates to an E. coli mutant strain having enhanced L-threonine productivity, which is obtained by introducing the permease of Corynebacterium origin, and to a method of producing L-threonine using the E. coli mutant strain.

Abstract translation: 本发明涉及到大肠杆菌具有增强的L-苏氨酸生产率的突变菌株，其全部通过引入棒状杆菌来源的通透获得，以及使用该突变体大肠杆菌菌株生产L-苏氨酸的方法。

公开(公告)号：EP3833764A1

公开(公告)日：2021-06-16

申请号：EP19848461.0

申请日：2019-08-07

Applicant: CJ Cheiljedang Corporation

Inventor： LEE, Ji Sun ,  CHANG, Dong Eun ,  KIM, Sang Jun ,  KIM, So Young

IPC: C12N15/69 ,  C12N15/70 ,  C12N9/12