公开(公告)号：WO2012099396A3

公开(公告)日：2012-07-26

申请号：PCT/KR2012/000444

申请日：2012-01-18

Applicant: CJ CHEILJEDANG CORPORATION ,  LEE, Kwang Ho ,  LEE, Keun Chul ,  LEE, Seok Myung ,  HWANG, Young Bin

Inventor： LEE, Kwang Ho ,  LEE, Keun Chul ,  LEE, Seok Myung ,  HWANG, Young Bin

IPC: C12N1/21 ,  C12N15/54 ,  C12N15/70 ,  C12N15/69 ,  C12P13/08

Abstract: The present invention provides a microorganism of the genus Escherichia having enhanced L-amino acid productivity, wherein the microorganism is transformed to have an enhanced NAD kinase activity and an inactivated activity of an enzyme having an amino acid sequence of SEQ ID NO. 2 encoded by tehB gene and a method for producing L-amino acids using the microorganism of the genus Escherichia.

公开(公告)号：EP3144385A1

公开(公告)日：2017-03-22

申请号：EP15837846.3

申请日：2015-09-04

Applicant: Cj Cheiljedang Corporation

Inventor： LEE, Ji Sun ,  LEE, Kwang Ho ,  KIM, Hyo Jin ,  LEE, Keun Chul ,  HWANG, Young Bin

IPC: C12N9/12 ,  C12N15/54 ,  C12N1/21 ,  C12P13/08

Abstract: The present invention relates to a novel variant RNA polymerase sigma factor 70 (σ 70 ) polypeptide, a polynucleotide encoding the same, a microorganism containing the polypeptide, and a method for producing L-threonine by using the microorganism.

Abstract translation: 本发明涉及一种新颖的变体的RNA聚合酶σ因子70（A 70）的多肽，编码它的多核苷酸，含有微生物的多肽，以及用于通过使用该微生物生产L-苏氨酸的方法。

公开(公告)号：EP3015547A1

公开(公告)日：2016-05-04

申请号：EP14818556.4

申请日：2014-04-24

Applicant: CJ Cheiljedang Corporation

Inventor： LEE, Ji Sun ,  LEE, Kwang Ho ,  KOH, Eun Sung ,  KIM, Hyung Joon ,  LEE, Keun Cheol ,  HWANG, Young Bin

IPC: C12N9/12 ,  C12N15/54 ,  C12N15/70 ,  C12P13/08

CPC classification number: C12N9/1247 ,  C07K14/245 ,  C12N15/70 ,  C12P13/08 ,  C12Y207/07006

Abstract: The present application relates to an L-threonine-producing microorganism and a production method for L-threonine using the same, and more specifically, to a microorganism having enhanced L-threonine productivity and a method for producing L-threonine in high yield using the same.

公开(公告)号：EP2803720A2

公开(公告)日：2014-11-19

申请号：EP13735653.1

申请日：2013-01-10

Applicant: Cj Cheiljedang Corporation

Inventor： LEE, Kwang Ho ,  PARK, Hye Min ,  LEE, Hyo Hyoung ,  HWANG, Young Bin ,  LEE, Seok Myung

IPC: C12N1/21 ,  C12N15/70 ,  C12P13/22

CPC classification number: C12P13/227 ,  C07K14/245 ,  C12N15/71 ,  H01L27/3276 ,  H01L51/5231

Abstract: The present invention relates to microorganisms of Escherichia coli having enhanced L-tryptophan productivity and to a method for producing L-tryptophan using the same. More particularly, the present invention relates to an Escherichia coli variant in which repression and attenuation control of the tryptophan operon is released and accumulation of anthranilate is reduced and thereby enhancing L-tryptophan productivity. The present invention also relates to a method for producing L-tryptophan using the Escherichia coli variant.

Abstract translation: 本发明涉及大肠杆菌具有增强的L-色氨酸的生产力的微生物和一种用于生产L-色氨酸使用相同的方法。 更具体地，本发明涉及在其中压制和色氨酸操纵子的衰减控制大肠杆菌变体被释放，邻氨基苯甲酸的积累减少，从而提高L-色氨酸的生产力。 因此，本发明涉及一种用于制造使用大肠杆菌变体L-色氨酸的方法。

公开(公告)号：EP2801611A2

公开(公告)日：2014-11-12

申请号：EP13733718.4

申请日：2013-01-07

Applicant: Cj Cheiljedang Corporation

Inventor： CHEONG, Ki Yong ,  LEE, Seok Myung ,  HWANG, Young Bin ,  LEE, Keun Cheol ,  LEE, Kwang Ho

IPC: C12N1/21 ,  C12P13/22 ,  C12N15/70

CPC classification number: C12P13/227 ,  C07K14/245 ,  C12N1/20 ,  C12N9/0053 ,  C12N9/0071 ,  C12P13/08 ,  C12Y114/11 ,  Y02P20/59

Abstract: The present invention relates to a microorganism able to produce L-threonine or L-tryptophan, and to a method for producing L-threonine or L-tryptophan by using same. More specifically, the present invention relates to: recombinant Escherichia coli which is more efficient in producing L-threonine or L-tryptophan by increasing the ability to produce ATP which is used as the most plentiful energy source in cells when producing L-threonine or L-tryptophan; and a method for producing L-threonine or L-tryptophan by using same.

公开(公告)号：EP3144385B1

公开(公告)日：2020-08-12

申请号：EP15837846.3

申请日：2015-09-04

Applicant: CJ Cheiljedang Corporation

Inventor： LEE, Ji Sun ,  LEE, Kwang Ho ,  KIM, Hyo Jin ,  LEE, Keun Chul ,  HWANG, Young Bin

IPC: C12N9/12 ,  C12N15/54 ,  C12P13/08 ,  C07K14/245

公开(公告)号：EP3015546B1

公开(公告)日：2020-05-27

申请号：EP14817261.2

申请日：2014-06-24

Applicant: CJ Cheiljedang Corporation

Inventor： PARK, Sang Hee ,  MOON, Jun Ok ,  LEE, Kwang Ho

IPC: C12N9/10 ,  C12N15/54 ,  C12N15/63 ,  C12N15/77 ,  C12N9/12 ,  C12P13/08

公开(公告)号：EP3078737B1

公开(公告)日：2019-04-10

申请号：EP14870476.0

申请日：2014-12-08

Applicant: CJ Cheiljedang Corporation

Inventor： MOON, Jun Ok ,  PARK, Sang Hee ,  HUH, Lan ,  LEE, Kwang Ho

IPC: C12N1/21 ,  C07K14/34 ,  C12P13/08

公开(公告)号：EP3015547B1

公开(公告)日：2018-10-03

申请号：EP14818556.4

申请日：2014-04-24

Applicant: CJ Cheiljedang Corporation

Inventor： LEE, Ji Sun ,  LEE, Kwang Ho ,  KOH, Eun Sung ,  KIM, Hyung Joon ,  LEE, Keun Cheol ,  HWANG, Young Bin

IPC: C12N9/12 ,  C12N15/54 ,  C12N15/70 ,  C12P13/08

CPC classification number: C12N9/1247 ,  C07K14/245 ,  C12N15/70 ,  C12P13/08 ,  C12Y207/07006

Abstract: The present application relates to an L-threonine-producing microorganism and a production method for L-threonine using the same, and more specifically, to a microorganism having enhanced L-threonine productivity and a method for producing L-threonine in high yield using the same.

公开(公告)号：EP2796555B1

公开(公告)日：2018-08-29

申请号：EP12859882.8

申请日：2012-12-21

Applicant: Cj Cheiljedang Corporation

Inventor： LEE, Kwang Ho ,  LIM, Sang Jo ,  MOON, Jun Ok ,  JANG, Jae Woo ,  PARK, Su Jin ,  PARK, Sang Hee

IPC: C12N15/52 ,  C12N15/63 ,  C12N15/74 ,  C12P13/08

CPC classification number: C12P13/08 ,  C12N9/1022 ,  C12N9/1217 ,  C12N9/93 ,  C12N15/52 ,  C12N15/63 ,  C12N15/74 ,  C12Y202/01001 ,  C12Y207/02004 ,  C12Y604/01001 ,  Y02P20/52

Abstract: The present invention relates to a modified polynucleotide encoding aspartate kinase (EC:2.7.2.4; hereinafter, referred to as LysC), transketolase (EC:2.2.1.1; hereinafter, referred to as Tkt) or pyruvate carboxylase (EC:6.4.1.1; hereinafter, referred to as Pyc), in which the initiation codon is substituted with ATG, a vector including the same, a microorganism transformed with the vector, and a method for producing L-lysine using the same.