公开(公告)号：US10900027B2

公开(公告)日：2021-01-26

申请号：US15766901

申请日：2016-10-07

Applicant: Cleveland State University

Inventor： Michael Kalafatis ,  Joseph Wiencek

IPC: C12N9/74 ,  A61P7/02 ,  A61K38/48 ,  C12N15/79 ,  A61K38/00

Abstract: During the process of coagulation, prothrombin is activated to α-thrombin by prothrombinase. Key residues in the structure of prothrombin allow for modulation of the activation of prothrombin. In certain embodiments, a recombinant prothrombin with at least one point mutation or deletion is provided.

公开(公告)号：US20210155918A1

公开(公告)日：2021-05-27

申请号：US17157130

申请日：2021-01-25

Applicant: Cleveland State University

Inventor： Michael Kalafatis ,  Joseph Wiencek

IPC: C12N9/74 ,  A61P7/02 ,  A61K38/48 ,  C12N15/79

Abstract: During the process of coagulation, prothrombin is activated to α-thrombin by prothrombinase. Key residues in the structure of prothrombin allow for modulation of the activation of prothrombin. In certain embodiments, a recombinant prothrombin with at least one point mutation or deletion is provided.

公开(公告)号：US11959110B2

公开(公告)日：2024-04-16

申请号：US17157130

申请日：2021-01-25

Applicant: Cleveland State University

Inventor： Michael Kalafatis ,  Joseph Wiencek

IPC: C12N9/74 ,  A61K38/48 ,  A61P7/02 ,  C12N15/79 ,  A61K38/00

CPC classification number: C12N9/6429 ,  A61K38/4833 ,  A61P7/02 ,  C12N15/79 ,  C12Y304/21005 ,  A61K38/00

Abstract: During the process of coagulation, prothrombin is activated to α-thrombin by prothrombinase. Key residues in the structure of prothrombin allow for modulation of the activation of prothrombin. In certain embodiments, a recombinant prothrombin with at least one point mutation or deletion is provided.

公开(公告)号：US11360077B2

公开(公告)日：2022-06-14

申请号：US15918635

申请日：2018-03-12

Applicant: Cleveland State University

Inventor： Michael Kalafatis ,  Katherine Turner

IPC: G01N33/50 ,  G01N33/574 ,  G01N15/14 ,  A61K31/352 ,  A61P35/00 ,  G01N15/10

Abstract: Disclosed are methods and compositions for identifying and treating certain conditions and diseases. In certain instances, the general inventive concepts provide methods for determining rhTRAIL sensitivity of a sample and/or methods and compositions for inducing apoptosis to treat conditions and diseases with rhTRAIL.

公开(公告)号：US20180348202A1

公开(公告)日：2018-12-06

申请号：US15918635

申请日：2018-03-12

Applicant: Cleveland State University

Inventor： Michael Kalafatis ,  Katherine Turner

IPC: G01N33/50 ,  G01N33/574 ,  G01N15/14

Abstract: Disclosed are methods and compositions for identifying and treating certain conditions and diseases. In certain instances, the general inventive concepts provide methods for determining rhTRAIL sensitivity of a sample and/or methods and compositions for inducing apoptosis to treat conditions and diseases with rhTRAIL.

公开(公告)号：US20180305677A1

公开(公告)日：2018-10-25

申请号：US15766901

申请日：2016-10-07

Applicant: Cleveland State University

Inventor： Michael Kalafatis ,  Joseph Wiencek

IPC: C12N9/74 ,  C12N15/79 ,  A61K38/48 ,  A61P7/02

CPC classification number: C12N9/6429 ,  A61K38/00 ,  A61K38/4833 ,  A61P7/02 ,  C12N15/79 ,  C12Y304/21005

Abstract: During the process of coagulation, prothrombin is activated to α-thrombin by prothrombinase. Key residues in the structure of prothrombin allow for modulation of the activation of prothrombin. In certain embodiments, a recombinant prothrombin with at least one point mutation or deletion is provided.