公开(公告)号：US11262349B2

公开(公告)日：2022-03-01

申请号：US16157727

申请日：2018-10-11

Applicant: Cleveland State University

Inventor： Moo-Yeal Lee ,  Xue-Long Sun

IPC: G01N33/50 ,  G01N33/543

Abstract: A multiplexed method of monitoring immune-cell responses to different ligands using a micropillar/microwell plate platform is disclosed. The method may include dispensing immune cells onto at least one micropillar chip and inserting the at least one micropillar into at least one microwell on a microwell chip, in which the at least one microwell contains at least one test compound. The method may also include immobilizing antibodies onto at least one micropillar on a micropillar chip and inserting the at least one micropillar into at least one microwell on a microwell chip, in which the at least one microwell contains a test compound. The method may also include treating the micropillar chip with at least one reactive polymer.

公开(公告)号：US20230310474A1

公开(公告)日：2023-10-05

申请号：US18109021

申请日：2023-02-13

Applicant: Cleveland State University ,  University of Tennessee Research Foundation

Inventor： Xue-Long Sun ,  Guoyun Chen

IPC: A61K31/7028 ,  A61P31/14

CPC classification number: A61K31/7028 ,  A61P31/14

Abstract: An antiviral composition contains a sialidase inhibitor. Methods for treating a viral infection include administering the composition to a patient. The sialidase inhibitor may be of general formula (l)





wherein R1 is selected from the group consisting of OH, O-acetyl, N3, OCOCH2X1 and NHCOCHX1; X1 is selected from the group consisting of H, a C1-C5 alkyl group, acetyl, propionyl, butyryl, valoryl, hexanoyl, pentanoyl, and 2-methylpropanyl; R2 is H or COCH2X2; X2 is selected from the group consisting of H, a C1-C5 alkyl group, acetyl, propionyl, butyryl, valoryl, hexanoyl, pentanoyl, and 2-methylpropanyl; R3 is selected from the group consisting of H, OH, COCH2X3 and OCOCH2X3; X3 is selected from the group consisting of H, a C1-C5 alkyl group, acetyl, propionyl, butyryl, valoryl, hexanoyl, pentanoyl, and 2-methylpropanoal; R4 is selected from the group consisting of H, OH, a C1-C6 alkyl group, and CH2X4; and X4 is H or a C1-C6 alkyl group.

公开(公告)号：US20190107532A1

公开(公告)日：2019-04-11

申请号：US16157727

申请日：2018-10-11

Applicant: Cleveland State University

Inventor： Moo-Yeal Lee ,  Xue-Long Sun

IPC: G01N33/50

Abstract: A multiplexed method of monitoring immune-cell responses to different ligands using a micropillar/microwell plate platform is disclosed. The method may include dispensing immune cells onto at least one micropillar chip and inserting the at least one micropillar into at least one microwell on a microwell chip, in which the at least one microwell contains at least one test compound. The method may also include immobilizing antibodies onto at least one micropillar on a micropillar chip and inserting the at least one micropillar into at least one microwell on a microwell chip, in which the at least one microwell contains a test compound. The method may also include treating the micropillar chip with at least one reactive polymer.