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公开(公告)号:US20200306183A1
公开(公告)日:2020-10-01
申请号:US16061772
申请日:2016-12-16
Inventor: Timothy Hughes , Xavier Mulet , Johan Basuki , Xiaojuan Hao
Abstract: The present invention relates to a polymer composite for controlled release of an agent. In particular, the present invention relates to a stimuli-responsive polymer composite that can provide for controlled release of an agent in response to light. The polymer composite may be particularly suitable for the controlled delivery of a drug that is modulated by light.
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公开(公告)号:US20230348674A1
公开(公告)日:2023-11-02
申请号:US18012815
申请日:2021-06-24
Inventor: Anh Tuan Nguyen , Johan Basuki , Timothy Hughes
CPC classification number: C08J3/075 , A61K9/06 , A61K38/385 , A61K47/34 , A61K47/36 , C08G73/0233 , C08G2210/00 , C08G2230/00 , C08J2379/02 , C08J2389/06
Abstract: Described herein is a method of preparing a thermoresponsive polymer biomacromolecule conjugate, the method comprising: preparing by living cationic ring opening polymerisation a thermoresponsive polymer selected from polyoxazoline, polyoxazine, or copolymer thereof, the so-formed thermoresponsive polymer having a living cation; and reacting the living cation with a nucleophilic functional group selected from carboxylate, amino, sulfate, sulfonate, phosphate, phosphonate and thiol of a biomacromolecule to conjugate the thermoresponsive polymer to the biomacromolecule; wherein in an aqueous liquid the so-formed thermoresponsive polymer biomacromolecule conjugate exhibits a gelation temperature and forms a hydrogel in that liquid above that gelation temperature.
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公开(公告)号:US20220110863A1
公开(公告)日:2022-04-14
申请号:US17506939
申请日:2021-10-21
Inventor: Timothy Hughes , Xavier Mulet , Johan Basuki , Xiaojuan Hao
Abstract: The present invention relates to a polymer composite for controlled release of an agent. In particular, the present invention relates to a stimuli-responsive polymer composite that can provide for controlled release of an agent in response to light. The polymer composite may be particularly suitable for the controlled delivery of a drug that is modulated by light.
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