公开(公告)号：US20180033513A1

公开(公告)日：2018-02-01

申请号：US15639315

申请日：2017-06-30

Applicant: Convergent R.N.R Ltd.

Inventor： Aharon BAR-DAVID ,  Miri MARKOVICH ,  Avigail KELLER ,  Zeev BURSHTEIN ,  Zeev HAREL

IPC: G21K1/06

CPC classification number: G21K1/067 ,  G21K1/06 ,  G21K2201/062

Abstract: An X-ray system for providing a converging X-rays comprising: (a) an X-ray source having an optical axis thereof; (b) an X-ray lens arrangement comprising at least one first ring having a first Bragg reflecting surface formed by a plurality of tiles made from single crystal. At least one ring is provided with at least one second ring mounted adjacently thereto along said optical axis in a coaxial manner; said second ring has a second Bragg reflecting surface reflecting surface thereof.

公开(公告)号：US20190175953A1

公开(公告)日：2019-06-13

申请号：US16258612

申请日：2019-01-27

Applicant: CONVERGENT R.N.R LTD

Inventor： Aharon BAR-DAVID ,  Miri MARKOVICH ,  Zeev BURSHTEIN ,  Zeev HAREL

IPC: A61N5/10

Abstract: A method of a radiotherapy or radiosurgery treatment comprises steps of: (a) providing a converging x-ray beam source configured for emitting a converging X-ray beam propagating along an axis thereof; (b) emitting the converging x-ray beam towards a volume of treatment (VOT) having a length along the axis of the converging X-ray beam ranging between 2 mm and 5 cm within a patient's body such that a waist portion is within the VOT; (c) propagating the beam through tissues previously located relative to the VOT (PO); the VOT per se and tissues distally located to the VOT (DO). The converging X-ray beam characterized by a convergent angle ranging between 2 and 30 degrees providing 80% to 100% of a maximum dose is received by the VOT and less than 60% of the maximum dose is received by the PO and the DO.

公开(公告)号：US20170232245A1

公开(公告)日：2017-08-17

申请号：US15503006

申请日：2015-08-12

Applicant: CONVERGENT R.N.R LTD

Inventor： Zeev HAREL ,  Zeev BURSHTEIN ,  Aharon BAR-DAVID ,  Miri MARKOVICH

IPC: A61M37/00 ,  A61K41/00 ,  A61N5/10

CPC classification number: A61M37/00 ,  A61K9/0009 ,  A61K41/00 ,  A61K41/0052 ,  A61M2037/0007 ,  A61N5/10 ,  A61N2005/1091 ,  A61N2005/1098

Abstract: The present invention provides a method for activating a pro-drug in vivo comprising the steps of: (a) administering a pro-drag to a subject; (b) locating a target site which has been at least partially dosed with the pro-drug at a predetermined concentration; and (d) exposing the target site to X-ray radiation. The step of exposing the target site to X-ray radiation is characterized by providing a converging X-ray of a controllable waist, substantially uniform at the target site, sufficient to convert the pro-drug to an active drug, whilst the X-ray photon dosage at the target site is higher than the X-ray photon dosage at an adjacent non target site.