公开(公告)号：DE69221404D1

公开(公告)日：1997-09-11

申请号：DE69221404

申请日：1992-02-10

Applicant: DADE MICROSCAN INC

Inventor： SHERMAN DAVID ,  BUSH CHARLENE ,  BENINSIG LAURA ,  VANDENBRINK KURT

IPC: C07H21/02 ,  A61K49/00 ,  C07H21/00 ,  C07H21/04 ,  C07H23/00 ,  C12Q1/68

Abstract: Rare earth chelate-conjugated oligonucleotides useful in nucleic acid hybridization assays and for generating chelate-labelled probes of any desired sequence are disclosed. The particular class of chelates utilized exhibit an unusually high efficiency of rare earth element capture, correlated with emission of a high level of signal in time-resolved fluorescence spectroscopy compared to other structurally related chelate compounds.

公开(公告)号：DE69221404T2

公开(公告)日：1998-02-05

申请号：DE69221404

申请日：1992-02-10

Applicant: DADE MICROSCAN INC

Inventor： SHERMAN DAVID ,  BUSH CHARLENE ,  BENINSIG LAURA ,  VANDENBRINK KURT

IPC: C07H21/02 ,  A61K49/00 ,  C07H21/00 ,  C07H21/04 ,  C07H23/00 ,  C12Q1/68

Abstract: Rare earth chelate-conjugated oligonucleotides useful in nucleic acid hybridization assays and for generating chelate-labelled probes of any desired sequence are disclosed. The particular class of chelates utilized exhibit an unusually high efficiency of rare earth element capture, correlated with emission of a high level of signal in time-resolved fluorescence spectroscopy compared to other structurally related chelate compounds.