公开(公告)号：KR840001511B1

公开(公告)日：1984-09-29

申请号：KR800003223

申请日：1980-08-14

Applicant: DAICEL CHEM ,  SAPPORO BREWERIES ,  ITO ETSUO

Inventor： KAWAI KIMITOSHI ,  SUGAWARA KUNIO ,  MORINAGA TSUYOSHI

IPC: A61K38/00 ,  A61K36/899 ,  A61P35/00 ,  C07K14/415 ,  A61K35/78

公开(公告)号：DE3064701D1

公开(公告)日：1983-10-06

申请号：DE3064701

申请日：1980-08-14

Applicant: DAICEL CHEM ,  SAPPORO BREWERIES ,  ITO ETSUO

Inventor： KAWAI KIMITOSHI ,  SUGAWARA KUNIO ,  MORINAGA TSUYOSHI

IPC: A61K38/00 ,  C07K14/415 ,  C07G7/00 ,  A61K37/02 ,  A23J1/12

Abstract: A new substance having antitumor activity is obtained from an epidermal portion of rice. A substance called RBF-P is obtained by adding ethanol to an aqueous alkaline extract of rice bran, removing the insolubles and precipitating the substance by addition of an acid. This substance comprises an active substance called RBF-PM, which is insoluble in methanol, and an active substance called RBF-X, which is soluble in acetone. The substance RBF-PM is a protein containing extremely little cystine and said protein can suppress solid cancers of mice. The substance RBF-X is a mixture of hexane-solubles such as fatty acids and a hexane-insoluble called RBF-H. A synergistic suppressive action on ascites hepatoma of mice is exhibited by the combination of the RBF-H and the fatty acids.

公开(公告)号：JPH0416181B2

公开(公告)日：1992-03-23

申请号：JP22777587

申请日：1987-09-11

Applicant: DAICEL CHEM

Inventor： SUGAWARA KUNIO

IPC: A61L9/01

公开(公告)号：JPH0274259A

公开(公告)日：1990-03-14

申请号：JP22618088

申请日：1988-09-09

Applicant: DAICEL CHEM

Inventor： SUGAWARA KUNIO ,  SHIGEMATSU AKIRA ,  IKEMATSU KIYOSHI

IPC: A61L9/01 ,  A61L2/18

Abstract: PURPOSE:To efficiently deodorize a malodor such as the spoilage smell of a stool tank, a barn or a shellfish by containing glyoxal, polyhydric alcohol and alkali in an amount necessary for holding the pH of a system to 7-9. CONSTITUTION:An aqueous glyoxal solution is mixed with a composition containing polyhydric alcohol and alkali and further containing a surfactant, perfume or the like arbitrarily at the time of use and the obtained aqueous composition is finally adjusted to pH7-9. When this composition is preserved for a long period of time, Cannizzaro reaction is gently advanced and the pH of the aqueous solution becomes acidic as a whole and the deodorizing action against hydrogen sulfide disappears but the aqueous solution held to pH7-9 shows deodorizing action against a wide range of a malodor and also shows bacteriostatic action to develop excellent capacity as a bacteriostatic deodorant. The sufficient concn. of glyoxal contained in this aqueous composition is 100ppm or more but content of about 0.01-3wt.% is pref. After this composition is sprayed, a maloder can be reduced to a large extent and working environment can be improved largely.

公开(公告)号：JPS61126058A

公开(公告)日：1986-06-13

申请号：JP24895484

申请日：1984-11-26

Applicant: Daicel Chem Ind Ltd

Inventor： SUGAWARA KUNIO ,  GOTO TATSUO

IPC: C07C231/16 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07C233/47

Abstract: PURPOSE: In a nitrogen atmosphere, an optically active N-acylaminoacid is directly heated to enable racemization in a short time, quantitatively without decomposition of the feedstock and product whereby the titled compound is obtained in high yield without discoloration.
CONSTITUTION: An optically active N-acylaminoacid such as N-acetyl-D- phenylalanine is racemized in a reactor after replacement in the reactor with nitrogen in an amount of more than 10 times the capacity of the reactor or under almost vacuum after replacement with a nitrogen gas by evacuation with an aspirator or vacuum pump, by heating directly the compound at 100W220°C to give the objective N-acyl-DL-aminoacid. The optically active N-acylaminoacid may be either of naturally occurring one, nonnatural one or neutral, acidic or basic N-acyl aminoacid.
COPYRIGHT: (C)1986,JPO&Japio

Abstract translation: 目的：在氮气气氛中，直接加热光学活性N-酰基氨基酸，以便在短时间内定量地进行外消旋化，定量地不分解原料和产物，从而以高产率获得标题化合物而不变色。 构成：在反应器中用氮气置换反应器的容量的10倍以上或在几乎真空下更换后，在反应器中旋转N-乙酰基-D-苯丙氨酸的光学活性N-酰基氨基酸在反应器中进行外消旋化 通过用吸气器或真空泵抽空，通过在100-220℃直接加热化合物，得到目的N-酰基-DL-氨基酸，得到氮气。 光学活性N-酰基氨基酸可以是天然存在的一种，非天然的，或中性的，酸性的或碱性的N-酰基氨基酸。

公开(公告)号：JPS58202000A

公开(公告)日：1983-11-25

申请号：JP8283182

申请日：1982-05-17

Applicant: Daicel Chem Ind Ltd

Inventor： KAWAI KIMITOSHI ,  KAGEYAMA SADAO ,  SUGAWARA KUNIO

IPC: C12Q1/34 ,  C12R1/34

Abstract: PURPOSE: To make it possible to determine the cellulase activity easily with a high sensitivity, by using a microfibrillated cellulose as a substrate for determining the activity.
CONSTITUTION: Pulp fibers are beaten to prepare a microfibrillated cellulose having ≥80% decomposition ratio by cellulase much higher than that of the carboxymethyl cellulose which has been conventionally used. The resultant microfibrillated cellulose is then diluted with a buffer solution to ≤0.25% solid content and kept at a given temperature. A cellulase solution is then added thereto and reacted therewith, and the temperature is then measured after the lapse of a given time by the conventional method to obain the aimed cellulase activity value.
COPYRIGHT: (C)1983,JPO&Japio

Abstract translation: 目的：通过使用微纤化纤维素作为底物来确定活性，可以高灵敏度地容易地测定纤维素酶活性。 构成：通过纤维素酶比通常使用的羧甲基纤维素高得多的纸浆纤维被打浆以制备具有≥80％分解率的微纤化纤维素。 然后将所得微纤化纤维素用缓冲溶液稀释至<= 0.25％固体含量并保持在给定温度。 然后向其中加入纤维素酶溶液并与其反应，然后通过常规方法在经过给定时间之后测量温度以获得目标纤维素酶活性值。

公开(公告)号：JPH11156376A

公开(公告)日：1999-06-15

申请号：JP34060097

申请日：1997-11-26

Applicant: DAICEL CHEM

Inventor： SUGAWARA KUNIO

IPC: B01D61/04 ,  B01D65/06 ,  C02F1/44 ,  C02F1/72 ,  C02F1/78

Abstract: PROBLEM TO BE SOLVED: To provide a filter membrane washing waste water treatment method taking the place of an activated sludge method making it possible to discharge washing waste water generated by washing a water purifying filter membrane with a chemical soln. on the spot where a membrane filter equipment is operated and capable of treating the washing waste water in a small space without using a large equipment like an activated sludge equipment. SOLUTION: Washing waste water generated by washing a filter membrane with a chemical soln. is subjected to chemical oxidation treatment using ozone at the normal temp. under an alkaline condition and/or a peroxide coexisting condition on the spot of a water purifying plant and the treated water is discharged as it is. Further, the treated water subjected to chemical oxidation treatment is treated by a reverse osmosis membrane apparatus.

公开(公告)号：JPH0391438A

公开(公告)日：1991-04-17

申请号：JP22907989

申请日：1989-09-04

Applicant: DAICEL CHEM

Inventor： SUGAWARA KUNIO

IPC: A22C21/00 ,  A01N37/06

Abstract: PURPOSE:To prepare a disinfecting bactericidal solution capable of being employed in processes for immersing, washing and cooling edible meat or chicken, having excellent disinfectant, bactericidal activities and used for treating the edible meat or chicken, by dissolving sorbic acid or a salt thereof in water. CONSTITUTION:Sorbic acid or a salt thereof, e.g. potassium sorbate, is dissolved in water in a concentration of 10-3000ppm.

公开(公告)号：JPH02104509A

公开(公告)日：1990-04-17

申请号：JP25794488

申请日：1988-10-12

Applicant: DAICEL CHEM

Inventor： SHIGEMATSU AKIRA ,  SUGAWARA KUNIO

IPC: A01N59/08

Abstract: PURPOSE:To provide an aqueous bactericidal composition exhibiting a stronger, fast-acting an persistent bactericidal action than the cases of single use, respectively, by adding a quaternary ammonium salt and a chlorine dioxide-generating agent such as a chlorite salt-protonic acid to an aqueous medium. CONSTITUTION:An aqueous bactericidal composition contains 20-2000ppm of a compound of the formula (R1 is hydrocarbon in which an O may intervene; R2 and R3 are 1-5C alkyl; R4 is 1-18C straight chain or branched alkyl or aralkyl; X is halogen ion or mineral acid ion) and a chlorine dioxide-generating agent (the concentration of the generated chlorine dioxide is 1-100ppm). The chlorine dioxide-generating agent is preferably a combination of a chlorite salt (preferably Na salt) and a protonic acid (preferably hydrochloric acid, dodecylbenzene sulfonic acid or a mixture thereof). The composition is safe for men and livestock because of having a sufficient activity at a low concentration and is convenient also at the points of workability, handling, etc., because the sterilization, disinfection and washing works of livestock barns can be performed only with the one pack solution.

公开(公告)号：JPH01175851A

公开(公告)日：1989-07-12

申请号：JP33621887

申请日：1987-12-29

Applicant: DAICEL CHEM

Inventor： SUGAWARA KUNIO

IPC: A61L9/01

Abstract: PURPOSE:To obtain a funeral use antiseptic deodorant facilitated in its handling with no hazard enabling chlorine dioxide gas to effectively display its effect by sealing a granular mixture, consisting of sodium chlorite, solid acid in a dry condition and inactive diluent in a dry condition, in a gas permeable bag unit. CONSTITUTION:A funeral use antiseptic deodorant seals a granular mixture, consisting of sodium chorite, solid acid in a dry condition and inactive diluent in a dry condition, in a gas permeable bag unit. The solid acid in use comes into contact with the sodium chlorite, generating chorine dioxide gas. The solid acid is used in the dry condition, and the solid acid, when it is placed in a wet condition, generates the chlorine dioxide gas in a short time, being not preferable. As the solid acid, weak acid of citric acid, adipic acid, oxalic acid, etc., is preferable. The diluent is for relaxing reaction between the sodium chlorite and the solid acid, having inactivity, and a dry condition is good. The granular mixture forms its composition proportion with 5-20% sodium chlorite, 5-20% solid acid and the rest of inactive diluent. While a grain size of respective granule is preferable about 200-1,000 microns.