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    CHLORHEXIDINE PREPARATION, NEW CHLORHEXIDINE SALT, SOLUTION CONTAINING THE SAME SALT AND ITS USE
    1.
    发明专利
    CHLORHEXIDINE PREPARATION, NEW CHLORHEXIDINE SALT, SOLUTION CONTAINING THE SAME SALT AND ITS USE 失效

    公开(公告)号：JP2000178189A

    公开(公告)日：2000-06-27

    申请号：JP35206999

    申请日：1999-12-10

    Applicant: DEGUSSA

    Inventor： WERLE PETER DR ,  MERZ FRIEDHELM ,  JOERGENSEN JUDITH N ,  TRAGESER MARTIN

    IPC: A61K9/08 ,  A61K9/00 ,  A61K31/155 ,  A61K47/22 ,  A61K47/26 ,  A61P31/02 ,  C07K19/00

    Abstract: PROBLEM TO BE SOLVED: To obtain a chlorhexidine preparation containing chlorhexidine in a water-soluble form by including a chlorhexidine base and a specific saccharic acid or its lactone at a specific molar ratio and further including an auxiliary at a specific amount. SOLUTION: This chlorhexidine preparation has a form of water-soluble powdery mixture. The chlorhexidine comprises (A) chlorhexidine base and (B) one or more saccharic acids or their lactone selected from a series of compounds comprising gluconic acid or gluconolactone, lactobionic acid (a compound of formula I), D-galactone-γ-lactone (a compound of formula II), L-mannonic acid-γ-lactone (a compound of formula III), D-(-)-gluconic acid-γ- lactone, D-(+)-galactouronic acid (a compound of formula IV) and α-D- heptagluconic acid-γ-lactone at a molar ratio of 1:>=2, preferably 1: (2.05-2.6) and further comprises (C) 0-10 wt.%, preferably

    4.
    发明专利
    未知

    公开(公告)号：AT490246T

    公开(公告)日：2010-12-15

    申请号：AT08101365

    申请日：2008-02-07

    Applicant: EVONIK DEGUSSA GMBH

    Inventor： REICHERT DIETMAR ,  SARICH MARTIN ,  MERZ FRIEDHELM

    IPC: C07D307/46

    Abstract: Preparation of 5-hydroxymethyl-furfural (I) from a saccharide (III) with 6C in the monosaccharide unit, via 2-acyloxymethyl-furfural (II), involves (a) reacting (III) with an acid or an acidic ion exchanger; (b) adding a carboxylic acid anhydride and/or chloride and reacting to give (II); (c) dissolving (II) in an alcohol; and (d) reacting with a base. Preparation of 5-hydroxymethyl-furfural (I) from a saccharide (III) with 6C in the monosaccharide unit, via 2-acyloxymethyl-furfurals of formula (II), involves: (a) reacting (III) with (i) an acid (other than an acidic ion exchanger (AIE)) in presence of alkali(ne earth) metal and/or aluminum cations or (ii) an AIE in H-form in presence of a polar aprotic solvent (the AIE subsequently being removed); (b) adding an anhydride and/or chloride of a carboxylic acid of formula R(COOH) x (IV) and reacting to give (II); (c) dissolving (II) in an alcohol; and (d) reacting with a base selected from (i) alkali metal (bi)carbonates, alkaline earth metal carbonates, hydroxides or basic salts and/or aluminum carbonate, hydroxide oxide-hydroxide or basic salts and (ii) basic ion exchangers in OH-form. x : 1 or 2; R : alkyl, alkenyl, aryl or heteroaryl if x = 1; or alkylene, alkenylene, arylene or heteroarylene if x = 2. An independent claim is included for the preparation of (II) by steps (a) and (b) of the process for preparing (I). [Image] ACTIVITY : Antibacterial; Cytostatic. MECHANISM OF ACTION : None given.

    5.
    发明专利
    未知

    公开(公告)号：DE102007007629A1

    公开(公告)日：2008-08-21

    申请号：DE102007007629

    申请日：2007-02-16

    Applicant: EVONIK DEGUSSA GMBH

    Inventor： REICHERT DIETMAR ,  SARICH MARTIN ,  MERZ FRIEDHELM

    IPC: C07D307/50 ,  A61K31/341 ,  A61P31/04 ,  C07D307/54

    Abstract: Preparation of 5-hydroxymethyl-furfural (I) from a saccharide (III) with 6C in the monosaccharide unit, via 2-acyloxymethyl-furfural (II), involves (a) reacting (III) with an acid or an acidic ion exchanger; (b) adding a carboxylic acid anhydride and/or chloride and reacting to give (II); (c) dissolving (II) in an alcohol; and (d) reacting with a base. Preparation of 5-hydroxymethyl-furfural (I) from a saccharide (III) with 6C in the monosaccharide unit, via 2-acyloxymethyl-furfurals of formula (II), involves: (a) reacting (III) with (i) an acid (other than an acidic ion exchanger (AIE)) in presence of alkali(ne earth) metal and/or aluminum cations or (ii) an AIE in H-form in presence of a polar aprotic solvent (the AIE subsequently being removed); (b) adding an anhydride and/or chloride of a carboxylic acid of formula R(COOH) x (IV) and reacting to give (II); (c) dissolving (II) in an alcohol; and (d) reacting with a base selected from (i) alkali metal (bi)carbonates, alkaline earth metal carbonates, hydroxides or basic salts and/or aluminum carbonate, hydroxide oxide-hydroxide or basic salts and (ii) basic ion exchangers in OH-form. x : 1 or 2; R : alkyl, alkenyl, aryl or heteroaryl if x = 1; or alkylene, alkenylene, arylene or heteroarylene if x = 2. An independent claim is included for the preparation of (II) by steps (a) and (b) of the process for preparing (I). [Image] ACTIVITY : Antibacterial; Cytostatic. MECHANISM OF ACTION : None given.

    CULTURE MEDIUM COMPRISING DIPEPTIDES
    7.
    发明专利
    CULTURE MEDIUM COMPRISING DIPEPTIDES 未知

    公开(公告)号：CA3055238A1

    公开(公告)日：2018-09-13

    申请号：CA3055238

    申请日：2018-03-02

    Applicant: EVONIK DEGUSSA GMBH

    Inventor： MERZ FRIEDHELM ,  KARAU ANDREAS ,  HERMANN THOMAS ,  KNAUP GUNTER

    IPC: C12N5/00

    Abstract: The present invention relates to a culture medium, preferably a cell culture medium, comprising at least one dipeptide, the dipeptide comprising asparagine (Asn) and glutamine (Gln). The invention further relates to the use of a culture medium of the invention for culturing cells, preferably plant cells, animal cells or mammalian cells. Another aspect of the invention relates to a method of manufacturing a cell culture product comprising the steps of (i) providing a cell capable of producing said cell culture product; (ii) contacting said cell with a culture medium according to the invention; and (iii) obtaining said cell culture product from said culture medium or from said cell.

    PROCESO PARA LA PRODUCCION DE 5-HIDROXIMETIL-FURFURAL CON 5-ACILOXIMETIL-FURFURAL COMO PORDUCTO INTERMEDIO.
    9.
    发明专利
    PROCESO PARA LA PRODUCCION DE 5-HIDROXIMETIL-FURFURAL CON 5-ACILOXIMETIL-FURFURAL COMO PORDUCTO INTERMEDIO. 未知

    公开(公告)号：ES2356995T3

    公开(公告)日：2011-04-15

    申请号：ES08101365

    申请日：2008-02-07

    Applicant: EVONIK DEGUSSA GMBH

    Inventor： REICHERT DIETMAR ,  SARICH MARTIN ,  MERZ FRIEDHELM

    IPC: C07D307/46

    Abstract: Proceso para la producción de un 5-aciloximetil-furfural de la fórmula (II) en la cual x es = 1 ó 2, R es un resto alquilo, alquenilo, arilo o heteroarilo, cuando x es = 1, R es un resto alquileno, alquenileno, arileno o heteroarileno, cuando x es = 2, a partir de un sacárido con 6 átomos de carbono en la unidad de monosacárido, que comprende los pasos: (a) transformación del sacárido con (i) un ácido, que no es un cambiador de iones ácido, en presencia de un catión metálico, seleccionado de iones de metal alcalino, iones de metal alcalinotérreo, iones aluminio y mezclas de los mismos, o (ii) un cambiador de iones ácido en la forma H en presencia de un disolvente polar aprótico, y separación del cambiador de iones ácido, en caso de ser utilizado, (b) adición a la mezcla del paso (a) de un anhídrido y/o cloruro de un ácido carboxílico R-(-COOH)x, donde R y x se definen como anteriormente, dejando reaccionar a fin de formar un 5-aciloximetil-furfural, y (c) obtención del 5-aciloximetil-furfural.

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