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公开(公告)号：US20170130345A1
公开(公告)日：2017-05-11
申请号：US15415700
申请日：2017-01-25
Inventor： Purnendu K. Dasgupta , Yongjing Chen , Kannan Srinivasan
CPC classification number: C25B7/00 , B01D15/168 , B01D61/44 , B01D61/445 , B01D61/46 , B01D2311/18 , B01D2311/2653 , G01N30/34
Abstract: An electrodialytic buffer generator is described. The buffer generator may include a central buffer-generating channel having an inlet and outlet, a second chamber, and a third chamber. The buffer-generating channel, the second chamber, and the third chamber may each include an electrode. The buffer generator may also include a first ion exchange barrier and a second ion exchange barrier. The first ion exchange barrier can be disposed between the second chamber and the buffer-generating channel. The second ion exchange barrier can be disposed between the third chamber and the buffer-generating channel.
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公开(公告)号：US11802857B2
公开(公告)日：2023-10-31
申请号：US17545249
申请日：2021-12-08
Applicant: DIONEX CORPORATION
Inventor： Yongjing Chen
CPC classification number: G01N30/96 , H01J49/0431 , G01N2030/965
Abstract: The eluent used in IC separation contains non-volatile salt which is not compatible with electrospray ionization-mass spectrometry (ESI-MS). A suppressor is required to convert the non-volatile salt into water or the volatile acid form (i.e. acetic acid). When the suppressor fails, the non-volatile salts will enter the MS and cause extensive shutdown and maintenance of the mass spectrometer. The suppressor voltage derivative is used to evaluate the most common suppressor failure modes, including disruption of regenerant flow and excessive backpressure on the suppressor due to clogging in the downstream, and to trigger the eluent pump to stop the eluent flow or to trigger the auxiliary valve to switch the flow to the mass spectrometer from eluent to water.
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公开(公告)号：US20230194485A1
公开(公告)日：2023-06-22
申请号：US17553956
申请日：2021-12-17
Applicant: Dionex Corporation
Inventor： Yongjing Chen , Yan Liu
CPC classification number: G01N30/8675 , G01N30/72 , G01N2030/328
Abstract: An analytical system comprises a chromatography column configured to separate a sample into one or more analytes; an ion removal device configured to remove at least ions of one charge from the mobile phase, the ion removal device fluidly coupled to an output of the chromatography column; an ion selective sensor configured to measure a signal corresponding to an activity of the ions of one charge in the mobile phase, the ion selective sensor fluidly coupled to an output of the ion removal device; an optional diverter valve that can interrupt the flow of the mobile phase; and a microprocessor configured to monitor the signal of the ion selective sensor and to either switch the optional diverter valve to interrupt the flow of the mobile phase or turn off the pump when the signal is greater than a predetermined threshold.
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公开(公告)号：US20240209517A1
公开(公告)日：2024-06-27
申请号：US18146485
申请日：2022-12-27
Applicant: DIONEX CORPORATION
Inventor： Yongjing Chen , Yan Liu
IPC: C25B1/02 , C25B1/22 , C25B11/042 , G01N30/62
CPC classification number: C25B1/02 , C25B1/22 , C25B11/042 , G01N30/62 , G01N2030/027
Abstract: An eluent generation module includes an electrolytic gas generator and an electrolytic eluent generator. The electrolytic gas generator includes a generation chamber having an inlet and an outlet; an outlet electrode within the generation chamber; a first ion exchange connector; a bulk solvent chamber separated from the generation chamber by the ion exchange connector; and a bulk solvent chamber electrode within the bulk solvent chamber. The electrolytic eluent generator includes an electrolyte chamber containing an aqueous electrolyte solution; an electrolyte chamber electrode within the electrolyte chamber; a second ion exchange connector; an eluent generation chamber separated from the electrolyte chamber by the second ion exchange connector; and an eluent generation chamber electrode.
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公开(公告)号：US20230341361A1
公开(公告)日：2023-10-26
申请号：US18186391
申请日：2023-03-20
Applicant: Dionex Corporation
Inventor： Yongjing Chen , Yan Liu
IPC: G01N30/96
CPC classification number: G01N30/96 , G01N2030/965
Abstract: A suppressor comprising one or more channels, a flow path for each of the channels, and one or more measurement probes positioned in the flow path is described. Each channel includes an inlet and an outlet. Each flow path includes an upstream path to the inlet, a channel stream path through the channel and connecting the inlet to the outlet, and a downstream path from the outlet. A system including the suppressor as well as methods implementing the suppressor are also described.
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Patent Agency Ranking
公开(公告)号：US11466373B2
公开(公告)日：2022-10-11
申请号：US15990043
申请日：2018-05-25
Inventor： Purnendu K. Dasgupta , Yongjing Chen , Kannan Srinivasan
Abstract: Buffer generators are described based on electrodialytic devices. The methods of using these devices can generate buffers for diverse applications, including separations, e.g., HPLC and ion chromatography. Also provided are chromatographic devices including the buffer generators, generally located upstream from a chromatography column, sample injector valve or both.
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公开(公告)号：US20250037053A1
公开(公告)日：2025-01-30
申请号：US18360586
申请日：2023-07-27
Applicant: Dionex Corporation
Inventor： Yongjing Chen , Yan Liu , Husam Al-Esawi
IPC: G06Q10/0633 , G06V30/224 , G08B21/18
Abstract: Disclosed herein are scientific instrument support systems, as well as related methods, computing devices, and computer-readable media. For example, in some embodiments, samples are tracked using unique identifiers. An autosampler may detect the samples using unique identifiers and provide alerts when the sample is placed in the wrong location or when an incorrect or incompatible workflow is selected for the sample.
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公开(公告)号：US20240269581A1
公开(公告)日：2024-08-15
申请号：US18167979
申请日：2023-02-13
Applicant: DIONEX CORPORATION
Inventor： Yongjing Chen , Yan Liu
CPC classification number: B01D15/426 , B01D61/445 , B01D61/46 , B01D15/361 , B01D2313/13 , B01D2313/50 , B01D2317/025
Abstract: An electrolytic eluent generator system includes a flow-through eluent generating zone, a first reservoir comprising configured to hold a first ion source; a second reservoir configured to hold a second ion source; a first ion exchange connector disposed between the first reservoir and the eluent generating zone, wherein the connector substantially prevents liquid flow through the ion exchange connector and transports ions only of the same charge as said first ions; and a second ion exchange connector disposed between the second reservoir and the eluent generation zone, wherein the connector substantially prevents liquid flow through the ion exchange connector and transports ions only of the same charge as said second ions. The second ion exchange connector is of opposite charge to the first ion exchange connector.
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公开(公告)号：US10208387B2
公开(公告)日：2019-02-19
申请号：US15415700
申请日：2017-01-25
Inventor： Purnendu K. Dasgupta , Yongjing Chen , Kannan Srinivasan
Abstract: An electrodialytic buffer generator is described. The buffer generator may include a central buffer-generating channel having an inlet and outlet, a second chamber, and a third chamber. The buffer-generating channel, the second chamber, and the third chamber may each include an electrode. The buffer generator may also include a first ion exchange barrier and a second ion exchange barrier. The first ion exchange barrier can be disposed between the second chamber and the buffer-generating channel. The second ion exchange barrier can be disposed between the third chamber and the buffer-generating channel.
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公开(公告)号：US20230176019A1
公开(公告)日：2023-06-08
申请号：US17545249
申请日：2021-12-08
Applicant: DIONEX CORPORATION
Inventor： Yongjing Chen
CPC classification number: G01N30/96 , H01J49/0431 , G01N2030/965
Abstract: The eluent used in IC separation contains non-volatile salt which is not compatible with electrospray ionization-mass spectrometry (ESI-MS). A suppressor is required to convert the non-volatile salt into water or the volatile acid form (i.e. acetic acid). When the suppressor fails, the non-volatile salts will enter the MS and cause extensive shutdown and maintenance of the mass spectrometer. The suppressor voltage derivative is used to evaluate the most common suppressor failure modes, including disruption of regenerant flow and excessive backpressure on the suppressor due to clogging in the downstream, and to trigger the eluent pump to stop the eluent flow or to trigger the auxiliary valve to switch the flow to the mass spectrometer from eluent to water.
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