公开(公告)号：WO1994008552A2

公开(公告)日：1994-04-28

申请号：PCT/US1993009751

申请日：1993-10-12

Applicant: DURA PHARMACEUTICALS, INC.

Inventor： DURA PHARMACEUTICALS, INC. ,  MECIKALSKI, Mark, Bernard ,  WILLIAMS, David, Richard ,  THUESON, David, Orel

IPC: A61K0

CPC classification number: A61K9/0075 ,  A61M15/0006 ,  A61M15/0016 ,  A61M15/0028 ,  A61M15/0033 ,  A61M15/0045 ,  A61M15/0048 ,  A61M16/0066

Abstract: A dry powder medicine inhaler has an impeller non-concentrically disposed in a mixing chamber. A motor spins the impeller at high speed. A plunger introduces a dose of powdered medicine into the chamber so that all powder particles are available for intermixing, disaggregation and comminution. An aperture receives a first stream of air and passes it towards the mouthpiece for inhalation by the user. A wall has at least one aperture for diverting a portion of a main air stream into the aerosolizing chamber to mix with the particles to form a fine, low-density, low velocity, dry mist of powdered medicine for inhalation by the user.

Abstract translation: 干粉吸入器具有非同心配置在混合室中的叶轮。 电机高速旋转叶轮。 柱塞将一定剂量的粉末药物引入腔室，使得所有粉末颗粒可用于混合，分解和粉碎。 一个孔接收第一个空气流，并将其传递给接口，以供使用者吸入。 壁具有至少一个用于将一部分主空气流转移到雾化室中的孔，以与颗粒混合以形成用于用户吸入的粉末状药物的细小，低密度，低速干雾。

公开(公告)号：WO1993014696A1

公开(公告)日：1993-08-05

申请号：PCT/US1993000820

申请日：1993-01-29

Applicant: DURA PHARMACEUTICALS, INC.

Inventor： DURA PHARMACEUTICALS, INC. ,  WILLIAMS, David, Richard

IPC: A61B05/087

CPC classification number: A61B5/0876

Abstract: A spirometer includes a chassis (3) with an enclosed curved passageway (33). The passageway (33) has an inlet (17), for receiving the forced expiration of the user, and an outlet (35), through which the expiration may be exhausted from the passageway (33). A vane (37) is eccentrically and pivotally mounted in the passageway, between the inlet (17) and the outlet (35) and is moved by the user's forced expiration. The vane (37) pivots from a first position closing off the passageway to a succession of other open positions forming a widening gap between the vane and part of the passageway as the vane moves therethrough. The vane (37) is eccentrically positioned in the passageway. A vane position measuring system preferably using a Hall Effect device (73) measures the position of the vane over time, during the interval when the user blows into the spirometer. A microprocessor (79) converts the signal from the vane position measuring system into various diagnostic parameters applicable to the user's lung condition.

Abstract translation: 肺活量计包括具有封闭弯曲通道（33）的底架（3）。 通道（33）具有用于接收使用者的强制通过的入口（17）和出口（35），通过该出口可以从通道（33）排出呼吸。 叶片（37）偏心地并且可枢转地安装在通道中，在入口（17）和出口（35）之间，并且被用户的强制通过移动。 叶片（37）从封闭通道的第一位置枢转到一系列其它打开位置，当叶片通过其移动时，叶片和通道的一部分之间形成加宽间隙。 叶片（37）偏心地定位在通道中。 优选使用霍尔效应装置（73）的叶片位置测量系统在用户吹入肺活量计的间隔期间测量叶片随时间的位置。 微处理器（79）将来自叶片位置测量系统的信号转换成适用于用户肺部状况的各种诊断参数。

公开(公告)号：WO1998003217A1

公开(公告)日：1998-01-29

申请号：PCT/US1997011440

申请日：1997-07-07

Applicant: DURA PHARMACEUTICALS, INC.

Inventor： DURA PHARMACEUTICALS, INC. ,  EISELE, Robert, F. ,  DAVIES, Karen ,  HOLTON, Nelson ,  KLINE, Tim ,  SMITH, Ian

IPC: A61M15/00

CPC classification number: A61M15/0045 ,  A61M15/0006 ,  A61M15/0025 ,  A61M15/0031 ,  A61M15/0033 ,  A61M15/0048 ,  A61M2016/0024 ,  A61M2202/064 ,  A61M2205/8206

Abstract: A drug powder inhaler has a cover plate (50) pivotally attached to a lid (38) on an inhaler housing (32). A lever is pivotally attached to the cover plate. A blister pack disk (42) is rotatably mounted on the housing under the cover plate. A powder duct (122) in the housing extends from a staging chamber (124) underneath one end of the lever to an aerosolizing chamber (120). An actuator (146) in the housing is pressed to shear open a blister (44) on the blister pack disk, and thereby deliver the drug dose contents of the blister into the staging chamber. A switch (170) senses pressure in the mouthpiece, and switches on a motor (160) spinning an impeller (162) within the aerosolizing chamber when inhalation is detected.

Abstract translation: 药物吸入器具有枢转地附接到吸入器壳体（32）上的盖（38）的盖板（50）。 杠杆枢转地附接到盖板。 泡罩包装盘（42）可旋转地安装在盖板下方的壳体上。 壳体中的粉末管道（122）从杆的一端的分级室（124）延伸到雾化室（120）。 壳体中的致动器（146）被按压以剪切泡罩包装盘上的泡罩（44），从而将泡罩的药物剂量内容物递送到分级室。 当检测到吸入时，开关（170）感测接口管中的压力，并且接通旋转雾化室内的叶轮（162）的马达（160）。

公开(公告)号：WO1996032978A1

公开(公告)日：1996-10-24

申请号：PCT/US1996003216

申请日：1996-03-11

Applicant: DURA PHARMACEUTICALS, INC.

Inventor： DURA PHARMACEUTICALS, INC. ,  SCHULTZ, Robert, K. ,  EISELE, Robert, F.

IPC: A61M13/00

CPC classification number: A61M15/0028 ,  A61M15/0006 ,  A61M2016/0024 ,  A61M2202/064

Abstract: A dry powder inhaler (10) has a front section (12) holding a unit dose cartridge (100) over a mixing chamber (78). An impeller is rotatably mounted within the mixing chamber (78). A rear section (14) of the inhaler includes a motor (30), a breath actuated switch (40), and pins (28) for positioning the unit dose cartridge (100) in the front section and driving a plunger (26) through the unit dose cartridge (100), to deposit a powdered drug into the mixing chamber (78), as the front (12) and rear (14) sections are brought together. A filter wheel (86, 92) allows air to flow forward from the rear section (14) into the mixing chamber (78), but substantially prevents stray drug powder from migrating rearwardly to the rear section (14). The front section (12) is preferably disposable, while the rear section (14) is advantageously reusable.

Abstract translation: 干粉吸入器（10）具有在混合室（78）上保持单位剂量盒（100）的前部分（12）。 叶轮可旋转地安装在混合室（78）内。 吸入器的后部（14）包括电动机（30），呼吸致动开关（40）和用于将单位剂量盒（100）定位在前部中的销（28），并驱动柱塞（26）通过 当前部（12）和后部（14）部分被集合时，单位剂量盒（100）将粉末状药物沉积到混合室（78）中。 过滤轮（86,92）允许空气从后部区段（14）向前流入混合室（78），但是基本上防止流动药物粉末向后移动到后部区段（14）。 前部（12）优选为一次性的，而后部（14）有利地可重复使用。

公开(公告)号：WO1997040819A1

公开(公告)日：1997-11-06

申请号：PCT/US1997006621

申请日：1997-04-21

Applicant: DURA PHARMACEUTICALS, INC.

Inventor： DURA PHARMACEUTICALS, INC. ,  SCHULTZ, Robert ,  WITHAM, Clyde ,  HILL, Malcolm

IPC: A61K09/12

CPC classification number: A61K9/0075 ,  A61K9/0073 ,  A61M15/0045 ,  A61M15/0048 ,  A61M2202/064

Abstract: A method for inhalation of a dry powder drug includes the steps of providing a dry powder drug composition having a drug particle size of from about 1-7 microns and a mass median aerodynamic diameter of the delivered aerosol of from about 3.5 to 5.5 microns. This composition is loaded into an inhaler which is generally flow rate independent, and with the inhaler having an inspiration flow resistance of about .12 to .21 (cmH2O) over the range of about 15-60 L/min. The patient inhales the drug composition from the inhaler with an inspiration flow rate of about 15-60 L/min, resulting in a delivery efficiency measured by respirable fraction greater than 20 %.

Abstract translation: 吸入干粉药物的方法包括提供具有约1-7微米的药物粒度和约3.5至5.5微米的递送气溶胶的质量中值空气动力学直径的干粉药物组合物的步骤。 该组合物装载到一般流速独立的吸入器中，并且吸入器的吸气流阻在约15-60L / min的范围内具有约0.12至1.21（cmH 2 O）1/2。 患者吸入吸入器中的药物组合物，吸气流速为约15-60升/分，导致通过可呼吸分数大于20％测定的输送效率。

公开(公告)号：WO1996033759A1

公开(公告)日：1996-10-31

申请号：PCT/US1996003408

申请日：1996-03-13

Applicant: DURA PHARMACEUTICALS, INC.

Inventor： DURA PHARMACEUTICALS, INC. ,  EISELE, Robert, F. ,  CAMERON, Allan ,  TITZLER, David ,  PORCHE, Leonard

IPC: A61M15/00

CPC classification number: A61M15/0045 ,  A61M15/0006 ,  A61M15/0025 ,  A61M15/0031 ,  A61M15/0033 ,  A61M15/0048 ,  A61M2016/0024 ,  A61M2202/064 ,  A61M2205/8206

Abstract: A powder storage and delivery system for a drug powder inhaler (20) has a carrier disk (46) with a blister shell (54) sealed by a shear layer (56). A tab (48) is adhered to the shear layer (56), underneath the blister shell (54). The carrier disk (46) is placed into a dry powder inhaler (20). An actuator (80) pushes against the tab (48), causing the shear layer (56) to tear away, releasing the powder drug contents (62) from the blister into the dry powder inhaler (20). A disk carrier (130) has bursting blisters (132) with a brittle blister shell (132) sealed with a foil lid (150), and covered by a plate (136). An actuator (160) moves against the plate (136), causing the plate (136) to buckle and the blister shell (132) to burst open, releasing powdered drug (62) into the dry powder inhaler (20).

Abstract translation: 用于药物粉末吸入器（20）的粉末储存和输送系统具有载体盘（46），其具有通过剪切层（56）密封的泡罩（54）。 在泡罩（54）下面的片（48）附着到剪切层（56）上。 托盘（46）被放置在干粉吸入器（20）中。 致动器（80）推动突片（48），导致剪切层（56）被撕开，将粉末药物内容物（62）从泡罩释放到干粉吸入器（20）中。 盘载体（130）具有破裂泡罩（132），其中脆性泡罩壳体（132）用箔盖（150）密封并且被板（136）覆盖。 致动器（160）抵靠板（136）移动，导致板（136）弯曲并且泡罩壳（132）爆裂，将粉末状药物（62）释放到干粉吸入器（20）中。

公开(公告)号：WO1995028192A1

公开(公告)日：1995-10-26

申请号：PCT/US1995004598

申请日：1995-04-13

Applicant: DURA PHARMACEUTICALS, INC.

Inventor： DURA PHARMACEUTICALS, INC. ,  WILLIAMS, David, R. ,  MECIKALSKI, Mark, B. ,  THUESON, David, O.

IPC: A61M11/00

CPC classification number: A61M15/0045 ,  A61K9/0075 ,  A61M11/001 ,  A61M15/0006 ,  A61M15/0008 ,  A61M15/0015 ,  A61M15/0016 ,  A61M15/002 ,  A61M15/0021 ,  A61M15/0033 ,  A61M15/0043 ,  A61M15/0048 ,  A61M2016/0021 ,  A61M2202/064 ,  A61M2205/3365 ,  A61M2205/8206 ,  A61M2206/16

Abstract: A dry powder medicine inhaler has a housing (403) and a mouthpiece (405). An aerosolizing chamber (407) is formed between a front wall (408) and a rear wall (409) of the housing (403). An impeller (411) is rotatably mounted on a pin (413), to rotate within the aerosolizing chamber (407). Radial inlets (425) pass through the housing (403) and enter substantially tangentially into the aerosolizing chamber (407). A blister pack (421) on the housing (403) provides individual doses of powdered drug mixture into the aerosolizing chamber (407). The user inhales from the mouthpiece (405) causing the impeller (411) to spin and mix the powdered drug with air, which is inhaled by the patient.

Abstract translation: 干粉药物吸入器具有壳体（403）和吸嘴（405）。 雾化室（407）形成在壳体（403）的前壁（408）和后壁（409）之间。 叶轮（411）可旋转地安装在销（413）上，以在雾化室（407）内旋转。 径向入口（425）穿过壳体（403）并且基本切向地进入雾化室（407）。 壳体（403）上的泡罩包装（421）将各种剂量的粉末状药物混合物提供到雾化室（407）中。 用户从接口（405）吸入，使得叶轮（411）将粉末状药物与被患者吸入的空气一起旋转并混合。