公开(公告)号：EP0525825A3

公开(公告)日：1993-04-07

申请号：EP92116023.0

申请日：1986-03-18

Applicant: Dade MicroScan Inc.

Inventor： Hale, Ron L. ,  Solas, Dennis W.

IPC: C07D213/79 ,  G01N33/533

CPC classification number: C07D213/79 ,  C07D213/38 ,  C07D405/14 ,  C07D473/08 ,  G01N33/533 ,  Y10S436/80

Abstract: Disclosed are substituted aryl-substituted 2,6-dicarboxy pyridine compounds of general formula

wherein Ar represents aryl, n" is an integer equal to the number of available bonding sites on Ar, each of the n" Rs, R' and R" are independently selected from hydrogen; electron-releasing groups including C 1 -C 4 alkoxy, C 1 -C 4 alkyl, amino, dialkylamino, aryl and aryloxy groups; and linking groups; and R * and R** are independently selected from metal ions, hydrogen and C 1 -C 4 alkyl groups. Said compounds are useful precursors for fluorescently detectable molecules comprising a substituted aryl-substituted 2,6-bis[N,N-di(carboxyalkyl)aminoalkyl]pyridine moiety.

公开(公告)号：EP0525825A2

公开(公告)日：1993-02-03

申请号：EP92116023.0

申请日：1986-03-18

Applicant: Dade MicroScan Inc.

Inventor： Hale, Ron L. ,  Solas, Dennis W.

IPC: C07D213/79 ,  G01N33/533

CPC classification number: C07D213/79 ,  C07D213/38 ,  C07D405/14 ,  C07D473/08 ,  G01N33/533 ,  Y10S436/80

Abstract: Disclosed are substituted aryl-substituted 2,6-dicarboxy pyridine compounds of general formula

wherein Ar represents aryl, n" is an integer equal to the number of available bonding sites on Ar, each of the n" Rs, R' and R" are independently selected from hydrogen; electron-releasing groups including C 1 -C 4 alkoxy, C 1 -C 4 alkyl, amino, dialkylamino, aryl and aryloxy groups; and linking groups; and R * and R** are independently selected from metal ions, hydrogen and C 1 -C 4 alkyl groups.
Said compounds are useful precursors for fluorescently detectable molecules comprising a substituted aryl-substituted 2,6-bis[N,N-di(carboxyalkyl)aminoalkyl]pyridine moiety.

Abstract translation: 公开了通式为CHEM的取代的芳基取代的2,6-二羧基吡啶化合物，其中Ar表示芳基，n“是等于Ar上可用键合位点数的整数，n”Rs，R '和R“独立地选自氢; 包括C1-C4烷氧基，C1-C4烷基，氨基，二烷基氨基，芳基和芳氧基的电子释放基; 和连接组; R *和R **独立地选自金属离子，氢和C 1 -C 4烷基。 所述化合物是包含取代的芳基取代的2,6-二[N，N-二（羧基烷基）氨基烷基]吡啶部分的荧光检测分子的有用前体。