公开(公告)号：EP0525181B1

公开(公告)日：1997-08-06

申请号：EP92907537.2

申请日：1992-02-10

Applicant: Dade MicroScan Inc.

Inventor： SHERMAN, David, Gordon ,  BUSH, Charlene, Eleanor ,  BENINSIG, Laura, Ann ,  VANDENBRINK, Kurt, Mathew

IPC: C12Q1/68 ,  C07H21/00

CPC classification number: A61K49/0054 ,  A61K49/0019 ,  C07H21/00 ,  C07H23/00 ,  C12Q1/6816 ,  G01N2458/40 ,  C12Q2565/627 ,  C12Q2563/137 ,  C12Q2563/107

Abstract: Rare earth chelate-conjugated oligonucleotides useful in nucleic acid hybridization assays and for generating chelate-labelled probes of any desired sequence are disclosed. The particular class of chelates utilized exhibit an unusually high efficiency of rare earth element capture, correlated with emission of a high level of signal in time-resolved fluorescence spectroscopy compared to other structurally related chelate compounds.