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    SPINAL FIXATION ASSEMBLY
    2.
    发明申请
    SPINAL FIXATION ASSEMBLY 审中-公开

    公开(公告)号：US20100160980A1

    公开(公告)日：2010-06-24

    申请号：US11816802

    申请日：2007-07-26

    Applicant: David A. Walsh ,  Karl Arthur Knobloch ,  Daniel R. Baker

    Inventor： David A. Walsh ,  Karl Arthur Knobloch ,  Daniel R. Baker

    IPC: A61B17/86

    CPC classification number: A61B17/7037 ,  A61B17/7002 ,  A61B17/7032

    Abstract: A locking mechanism (100) and method of fixation, such as the fixation of a fixation device (104) like a bone screw and of a rod (106) to the spine. The locking mechanism (100) includes a body (102), an insert (108, 308), a rod seat (110, 310) and a set screw. The body (102) includes a bottom portion (114) configured to receive the fixation device (104) and the insert (108, 308) but prevents the insert (108, 308) and fixation device (104) from passing therethrough once the insert (108, 308) and fixation device (104) are engaged. The body (102) further includes a side portion (120) configured to receive the rod (106). Between the rod (106) and the insert (108, 308) is a rod seat (110, 310).

    Ophthalmic aspirator-irrigator with valve
    5.
    发明授权
    Ophthalmic aspirator-irrigator with valve 失效
    带阀的眼科吸气器 - 冲洗器

    公开(公告)号：US4764165A

    公开(公告)日：1988-08-16

    申请号：US66347

    申请日：1987-06-25

    Applicant: Harry G. Reimels ,  David A. Walsh ,  Michael J. Arsenault

    Inventor： Harry G. Reimels ,  David A. Walsh ,  Michael J. Arsenault

    IPC: A61B17/00 ,  A61B46/23 ,  A61F9/007 ,  A61M1/00

    CPC classification number: A61F9/00736 ,  A61B2017/00977 ,  A61B2046/236

    Abstract: An ophthalmic aspirator-irrigator system for use during cataract surgery is disclosed. The system frees both hands of the surgeon for the surgical tasks and leaves the automatic operation of the system to a single control input operated by a foot pedal. The pedal controls both the aspiration and ejection functions as well as their respective speeds. The ophthalmic aspirator-irrigator system essentially comprises a hand-held device, a control box operable by the foot pedal and a power cord connecting the device with the box. A source of fluid is connected via a tube to the device to effect the irrigation function. The control box includes a power source and a circuit coupled to the source and via the cord to the device. Preferably, the circuit includes a bridge output network controlled by a linear motion slide type potentiometer controlled by the foot pedal. The circuit further includes dual DC amplifiers and a pulse-width modulated gate circuit to operate the device bidirectionally with a smooth, continuous and variable speed. The foot pedal has two zero control positions: in its off, non-depressed position and in its off position about midway through the pedal's downward travel. A vacuum limiting valve assembly permits the system readily to be adapted to posterior capsule polishing following the break-up and removal of the cortex.

    Abstract translation: 公开了一种在白内障手术期间使用的眼科抽吸器 - 冲洗器系统。 系统释放外科医生的双手进行手术任务，并将系统的自动操作放置到由脚踏板操作的单个控制输入。 踏板控制吸气和排出功能以及各自的速度。 眼科抽吸器 - 冲洗器系统基本上包括手持式装置，可由脚踏板操作的控制箱和将装置与箱连接的电源线。 流体源经由管连接到装置以实现灌溉功能。 控制箱包括电源和耦合到源极并通过电线耦合到该装置的电路。 优选地，电路包括由脚踏板控制的线性运动滑动型电位器控制的桥输出网络。 该电路还包括双直流放大器和脉冲宽度调制门电路，以平滑，连续和可变的速度双向操作设备。 脚踏板具有两个零控制位置：在其关闭，非踩下位置以及关于踏板向下行进的中途的关闭位置。 真空限制阀组件允许系统容易地适应于在皮质分解和去除之后的后胶囊抛光。

    Cis and trans-3-aryloxy-4-hydroxypyrrolidines used as anti-arrhythmics
    6.
    发明授权
    Cis and trans-3-aryloxy-4-hydroxypyrrolidines used as anti-arrhythmics 失效
    用作抗心律失常药的顺式和反式-3-芳氧基-4-羟基吡咯烷

    公开(公告)号：US4585785A

    公开(公告)日：1986-04-29

    申请号：US128696

    申请日：1980-03-10

    Applicant: David A. Walsh ,  William J. Welstead, Jr.

    Inventor： David A. Walsh ,  William J. Welstead, Jr.

    IPC: C07D207/12 ,  C07D207/20 ,  C07D491/04 ,  A61K31/40

    CPC classification number: C07D491/04 ,  C07D207/12 ,  C07D207/20

    Abstract: Cis and trans-3-aryloxy-4-hydroxypyrrolidines and derivatives thereof having the formula: ##STR1## are disclosed wherein R.sub.1 is hydrogen, loweralkyl, benzyloxycarbonyl and N-loweralkylcarbamoyl; R.sub.2 is hydrogen, lower alkyl, cycloalkyl, phenylalkyl, benzyloxycarbonyl, carbamoyl, N-loweralkylcarbamoyl, N-diloweralkylcarbamoyl and parafluorobenzoyl-lower-alkyl; Ar is phenyl, substituted phenyl, 1-naphthyl, 2-naphthyl, 1-indenyl and 2-indenyl and pharmaceutically acceptable acid addition and quaternary salts thereof. The compounds have antidepressant, antihypertensive and antiarrythmic activity in animals.

    Abstract translation: 公开了具有下式的顺式和反式-3-芳氧基-4-羟基吡咯烷及其衍生物：其中R 1是氢，低级烷基，苄氧基羰基和N-低级烷基氨基甲酰基; R2是氢，低级烷基，环烷基，苯基烷基，苄氧基羰基，氨基甲酰基，N-低级烷基氨基甲酰基，N-二低级烷基氨基甲酰基和九氟苯甲酰基 - 低级烷基; Ar是苯基，取代的苯基，1-萘基，2-萘基，1-茚基和2-茚基及其药学上可接受的酸加成盐和季盐。 该化合物在动物中具有抗抑郁，抗高血压和抗焦虑作用。

    2-Amino-3-(alkylthiobenzoyl)-phenylacetic acids
    7.
    发明授权
    2-Amino-3-(alkylthiobenzoyl)-phenylacetic acids 失效
    2-氨基-3-（烷硫基苯甲酰基） - 苯乙酸

    公开(公告)号：US4503073A

    公开(公告)日：1985-03-05

    申请号：US554420

    申请日：1983-11-22

    Applicant: David A. Walsh ,  Dwight A. Shamblee

    Inventor： David A. Walsh ,  Dwight A. Shamblee

    IPC: A61K31/235 ,  C07C149/43 ,  A61K31/195 ,  A61K31/24

    CPC classification number: A61K31/235

    Abstract: Novel 2-amino-3-(alkylthiobenzoyl)phenylacetic acids, esters and metal salts have the formula: ##STR1## wherein R is hydrogen or lower alkyl, R.sup.1 is hydrogen, lower alkyl or pharmaceutically acceptable metal cation, R.sup.2 is hydrogen, halogen, lower alkyl or lower alkoxy, Am is primary amino (--NH.sub.2), methylamino or dimethylamino. The compounds have anti-inflammatory activity; have effective analgesic activity, and inhibit blood platelet aggregation.

    Abstract translation: 新型2-氨基-3-（烷硫基苯甲酰基）苯乙酸，酯和金属盐具有下式：其中R是氢或低级烷基，R 1是氢，低级烷基或药学上可接受的金属阳离子，R 2是氢，卤素， 低级烷基或低级烷氧基，Am是伯氨基（-NH 2），甲基氨基或二甲基氨基。 该化合物具有抗炎活性; 有效镇痛活性，抑制血小板聚集。

    Method of producing an inhibitory effect on blood platelet aggregation
    8.
    发明授权
    Method of producing an inhibitory effect on blood platelet aggregation 失效
    产生对血小板聚集的抑制作用的方法

    公开(公告)号：US4313949A

    公开(公告)日：1982-02-02

    申请号：US234532

    申请日：1981-02-17

    Applicant: James R. Shanklin, Jr. ,  Dwight A. Shamblee ,  David A. Walsh

    Inventor： James R. Shanklin, Jr. ,  Dwight A. Shamblee ,  David A. Walsh

    IPC: C07D295/185 ,  A61K31/535 ,  A61K31/165

    CPC classification number: C07D295/185

    Abstract: Novel 2-amino-3-benzoyl-phenylacetamides are provided having the formula: ##STR1## wherein R represents hydrogen or lower alkyl, R.sup.1 and R.sup.2 represent hydrogen, lower alkyl, cycloalkyl, phenyl and phenyl substituted by lower alkyl, lower alkoxy, halogen, nitro and trifluoromethyl, and R.sup.1 and R.sup.2 when taken together with the adjacent nitrogen may form a heterocyclic residue; X represents hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl; Y represents hydrogen, lower alkyl, lower alkoxy, halogen, trifluoromethyl, lower alkylthio, lower alkyloxythio or lower alkyldioxythio; Am is primary amino (--NH.sub.2), methylamino or dimethylamino, and n is 1 to 3 inclusive. The compounds exhibit anti-inflammatory, antipyretic, anti-blood platelet aggregation and analgetic pharmacological activities.

    Abstract translation: 提供了新的2-氨基-3-苯甲酰基 - 苯基乙酰胺，其具有下式：其中R表示氢或低级烷基，R 1和R 2表示氢，低级烷基，环烷基，苯基和被低级烷基，低级烷氧基，卤素 硝基和三氟甲基，当R 1和R 2与相邻的氮原子一起时可以形成杂环残基; X表示氢，低级烷基，低级烷氧基，卤素或三氟甲基; Y代表氢，低级烷基，低级烷氧基，卤素，三氟甲基，低级烷硫基，低级烷硫氧基或低级烷基二氧硫基; Am是伯氨基（-NH 2），甲基氨基或二甲基氨基，n是1〜3。 该化合物具有抗炎，解热，抗血小板聚集和止痛药理作用。

    1-Substituted-3-arylthio-4-hydroxypyrrolidines
    9.
    发明授权
    1-Substituted-3-arylthio-4-hydroxypyrrolidines 失效
    1-取代的3-芳硫基-4-羟基吡咯烷

    公开(公告)号：US4251541A

    公开(公告)日：1981-02-17

    申请号：US2103

    申请日：1979-01-09

    Applicant: David A. Walsh

    Inventor： David A. Walsh

    IPC: A61K31/40 ,  A61P25/00 ,  A61P25/24 ,  A61P25/26 ,  C07D207/12 ,  C07D207/20 ,  C07D491/04

    CPC classification number: C07D491/04 ,  C07D207/12 ,  C07D207/20

    Abstract: Trans isomers of 1-substituted-3-arylthio-4-hydroxypyrrolidines and derivatives thereof having the formula: ##STR1## are disclosed wherein R.sub.1 is hydrogen, lower-alkyl, --C(O)NH-lower-alkyl and --C(O)-NH-phenyl; R.sub.2 is lower-alkyl, cycloalkyl and phenylalkyl; Ar is phenyl and substituted phenyl and the pharmaceutically acceptable addition salts thereof. The compounds have antidepressant activity in animals.

    Abstract translation: 公开了具有下式的1-取代-3-芳硫基-4-羟基吡咯烷及其衍生物的反式异构体：其中R 1是氢，低级烷基，-C（O）NH-低级烷基和-C（O ）-N-苯基; R2是低级烷基，环烷基和苯基烷基; Ar是苯基和取代的苯基及其药学上可接受的加成盐。 这些化合物在动物中具有抗抑郁活性。

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