公开(公告)号：US10071310B2

公开(公告)日：2018-09-11

申请号：US14805552

申请日：2015-07-22

Applicant: David J. Anderson ,  Senis Busayapongchai

Inventor： David J. Anderson ,  Senis Busayapongchai

IPC: G10L17/00 ,  G10L15/00 ,  H04L29/06 ,  A63F13/424 ,  A63F13/215 ,  A63F13/79 ,  A63F13/54

CPC classification number: A63F13/424 ,  A63F13/12 ,  A63F13/215 ,  A63F13/54 ,  A63F13/79 ,  A63F2300/1081 ,  A63F2300/50 ,  A63F2300/6072 ,  A63F2300/6081 ,  G10L15/00 ,  G10L17/00 ,  H04L65/00

Abstract: A thick-game client device includes all of the game data processing on-board while a thin-game client device includes only a small portion of game data processing such as to render visual displays while the majority of the game data processing is network based. A thick-voice client devices includes all of the voice processing on-board while a thin-voice client device includes only a small portion of the voice processing such as to generate acoustic parameter data discussed below while the remainder of the voice processing occurs at a voice services node. It will be appreciated that a client device may be thick with respect to both game processing and voice processing, may be thick with respect to one type of processing and thin with respect to the other, or may be thin with respect to both types of processing.

公开(公告)号：US20130091591A1

公开(公告)日：2013-04-11

申请号：US13597626

申请日：2012-08-29

Applicant: Hai U. Wang ,  Zhoufeng Chen ,  David J. Anderson

Inventor： Hai U. Wang ,  Zhoufeng Chen ,  David J. Anderson

IPC: A61K49/00 ,  A61K39/395 ,  A61K47/48 ,  A01K67/027

CPC classification number: C12N15/8509 ,  A01K67/0275 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0375 ,  A61K39/3955 ,  A61K49/00 ,  A61K49/0002 ,  A61K49/0008 ,  C07K14/705 ,  C07K16/2866 ,  C07K16/30 ,  C07K2317/76 ,  C12N5/0691 ,  C12N2503/02 ,  G01N33/573 ,  G01N33/6863 ,  G01N2333/52

Abstract: Arterial and venous endothelial cells are molecularly distinct from the earliest stages of angiogenesis. This distinction is revealed by expression on arterial cells of a transmembrane ligand, called EphrinB2 whose receptor EphB4 is expressed on venous cells. Targeted disruption of the EphrinB2 gene prevents the remodeling of veins from a capillary plexus into properly branched structures. Moreover, it also disrupts the remodeling of arteries, suggesting that reciprocal interactions between pre-specified arterial and venous endothelial cells are necessary for angiogenesis. This distinction can be used to advantage in methods to alter angiogenesis, methods to assess the effect of drugs on artery cells and vein cells, and methods to identify and isolate artery cells and vein cells, for example.

Abstract translation: 动脉和静脉内皮细胞与血管生成的最早阶段分子不同。 通过在受体EphB4在静脉细胞上表达的称为EphrinB2的跨膜配体的动脉细胞上的表达来揭示这种区别。 EphrinB2基因的靶向破坏阻止了从毛细血管丛将静脉重构成适当的分支结构。 此外，它还破坏动脉重塑，这表明预先规定的动脉和静脉内皮细胞之间的相互作用对于血管发生是必需的。 这种区别可用于改变血管生成的方法，评估药物对动脉细胞和静脉细胞的作用的方法，以及鉴定和分离动脉细胞和静脉细胞的方法。

公开(公告)号：US08332046B2

公开(公告)日：2012-12-11

申请号：US12848828

申请日：2010-08-02

Applicant: David J. Anderson ,  Rio J. Vetter ,  Jamille F. Hetke ,  Daryl R. Kipke

Inventor： David J. Anderson ,  Rio J. Vetter ,  Jamille F. Hetke ,  Daryl R. Kipke

IPC: A61N1/05

CPC classification number: A61B5/04001 ,  A61N1/0534 ,  A61N1/0539 ,  Y10T29/49204

Abstract: A neural interface system including an electrode array and a carrier that supports the electrode array, in which the electrode array includes a substrate rolled into a three-dimensional shape, a plurality of conductive traces patterned on the substrate and adapted to transmit electrical signals, and a plurality of elliptically shaped, externally facing electrode sites coupled to the plurality of conductive traces that electrically communicate with their surroundings. The plurality of electrodes are arranged in a triangular lattice circumferentially around and axially along the carrier, and the substrate includes an edge that extends axially along the carrier and is constrained between a first axial row portion of the plurality of electrode sites and a second axial row portion of the plurality of electrode sites adjacent to the first axial row portion.

Abstract translation: 一种神经接口系统，包括支撑电极阵列的电极阵列和载体，其中电极阵列包括滚动成三维形状的基底，在基底上图案化并适于透射电信号的多个导电迹线，以及 耦合到与其周围环境电连通的多个导电迹线的多个椭圆形的外部对置的电极位置。 所述多个电极沿着所述载体围绕并且轴向地布置成三角形晶格，并且所述基板包括沿着所述载体轴向延伸并且被约束在所述多个电极位置的第一轴向行部分和第二轴向行 多个电极位置的与第一轴向行部分相邻的部分。

公开(公告)号：US08229085B2

公开(公告)日：2012-07-24

申请号：US11888074

申请日：2007-07-31

Applicant: David J. Anderson

Inventor： David J. Anderson

IPC: H04M1/64

CPC classification number: H04M3/5307 ,  G06F17/279 ,  H04M1/64 ,  H04M3/53333

Abstract: Embodiments are provided for utilizing speech analytics for automatically managing messages in a communications network. A message from a calling party to an unavailable called party is recorded in a messaging management module. The messaging management module automatically identifies a category for assigning to the content of the message based on information associated with the unavailable called party or a calling party and associates a language model with the message content based on the category. An analysis module utilizes the language model to identify grammar making up the message content. The messaging management module automatically performs a messaging management function on the message content based on a set of rules. The messaging management function may include automatically determining a priority for the message (enabling the message to be retrieved out of order) or automatically triggering an action in response to the message which is directed to the unavailable called party.

Abstract translation: 提供实施例以利用语音分析来自动管理通信网络中的消息。 从呼叫方到不可用呼叫方的消息被记录在消息收发管理模块中。 消息管理模块基于与不可用的被叫方或主叫方相关联的信息，自动识别用于分配消息的内容的类别，并且基于该类别将语言模型与消息内容相关联。 分析模块利用语言模型来识别构成消息内容的语法。 消息管理模块基于一组规则自动对消息内容执行消息管理功能。 消息收发管理功能可以包括自动确定消息的优先级（使得消息无法被检索出来）或响应于针对不可用被叫方的消息来自动触发动作。

公开(公告)号：US20120073001A1

公开(公告)日：2012-03-22

申请号：US13132268

申请日：2009-11-30

Applicant: Xinzhong Dong ,  Qin Liu ,  David J. Anderson

Inventor： Xinzhong Dong ,  Qin Liu ,  David J. Anderson

IPC: A61K49/00 ,  A61K31/439 ,  C07D453/02 ,  C07H21/00 ,  C07H21/02 ,  C12N15/113 ,  C12N15/63 ,  C12N15/85 ,  C12N5/10 ,  A61K31/56 ,  C12Q1/68 ,  G01N33/566 ,  C12Q1/02 ,  A61P17/04 ,  A61K31/7088

CPC classification number: C12N15/1138 ,  A61K31/439 ,  A61K31/46 ,  A61K31/56 ,  A61K31/7088 ,  A61K31/713 ,  A61K45/06 ,  C07K14/705 ,  G01N33/5023 ,  G01N33/5041 ,  A61K2300/00

Abstract: The invention features therapeutic compositions comprising agents useful for the treatment or prevention of pruritis, and methods useful for identifying such agents.

Abstract translation: 本发明的特征在于包含可用于治疗或预防瘙痒症的药剂的治疗组合物，以及用于鉴定这些药物的方法。

公开(公告)号：US20110287480A1

公开(公告)日：2011-11-24

申请号：US12941936

申请日：2010-11-08

Applicant: David J. Anderson ,  Qiufa Ma ,  Lukas Sommer

Inventor： David J. Anderson ,  Qiufa Ma ,  Lukas Sommer

IPC: C12P21/00 ,  C12N1/21 ,  C12N1/00 ,  C12N1/15 ,  C07K16/18 ,  C12N5/10 ,  G01N33/566 ,  C07H21/00 ,  C07K14/00 ,  C12N15/63 ,  C12N1/19

CPC classification number: C07K14/475

Abstract: The invention relates to novel neurogenin proteins, nucleic acids and antibodies.

Abstract translation: 本发明涉及新型神经元蛋白，核酸和抗体。

公开(公告)号：US20110118301A1

公开(公告)日：2011-05-19

申请号：US13012130

申请日：2011-01-24

Applicant: Michael R. Schrimpf ,  Kevin B. Sippy ,  David J. Anderson ,  William H. Bunnelle ,  Diana L. Nersesian

Inventor： Michael R. Schrimpf ,  Kevin B. Sippy ,  David J. Anderson ,  William H. Bunnelle ,  Diana L. Nersesian

IPC: A61K31/439 ,  C07D409/12 ,  C07D401/12 ,  C07D495/04 ,  A61P25/00 ,  A61P25/28 ,  A61P25/18 ,  A61P29/00 ,  A61P15/08 ,  A61P9/10 ,  C07D403/04

CPC classification number: C07D487/04

Abstract: The invention relates to amine-substituted aza-adamantane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.Radiolabelled compounds useful for evaluating the binding affinity to α7 nicotinic acetylcholine receptors also are described.

Abstract translation: 本发明涉及胺取代的氮杂 - 金刚烷衍生物，包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。 还描述了可用于评估对α7烟碱乙酰胆碱受体的结合亲和力的放射性标记化合物。

公开(公告)号：US07941202B2

公开(公告)日：2011-05-10

申请号：US11545353

申请日：2006-10-10

Applicant: Jamille F. Hetke ,  Daryl R. Kipke ,  David S. Pellinen ,  David J. Anderson

Inventor： Jamille F. Hetke ,  Daryl R. Kipke ,  David S. Pellinen ,  David J. Anderson

IPC: A61B5/04 ,  A61N1/05

CPC classification number: A61B5/04001 ,  A61B2562/0209 ,  A61B2562/043 ,  A61N1/0534 ,  Y10T29/49117 ,  Y10T29/49147 ,  Y10T29/49149 ,  Y10T29/49155 ,  Y10T29/49211

Abstract: Some embodiments of the invention comprise a customizable multichannel microelectrode array with a modular planar microfabricated electrode array attached to a carrier and a high density of recording and/or stimulation electrode sites disposed thereon. Novel methods of making and using same are also disclosed.

Abstract translation: 本发明的一些实施例包括可定制的多通道微电极阵列，其具有连接到载体的模块化平面微加工电极阵列和设置在其上的高密度记录和/或刺激电极位置。 还公开了制备和使用它们的新方法。

公开(公告)号：US07732206B2

公开(公告)日：2010-06-08

申请号：US11397200

申请日：2006-04-04

Applicant: David J. Anderson ,  Qiao Zhou

Inventor： David J. Anderson ,  Qiao Zhou

IPC: C12N15/00 ,  C12N5/071 ,  C12N5/00

CPC classification number: C12N5/0622 ,  C12N2506/02 ,  C12N2506/08 ,  C12N2510/00

Abstract: The invention relates to methods and reagents for promoting the differentiation of oligodendrocytes from stem cells, by co-activating the Olig genes and the Nkx2.2 genes, and the use of the differentiated oligodendrocytes thus obtained in treating diseases, such as Multiple Sclerosis (MS). The invention also relates to the use of OLPs and oligodendrocytes thus obtained for drug screening.

Abstract translation: 本发明涉及用于通过共同活化Olig基因和Nkx2.2基因促进少突胶质细胞从干细胞分化的方法和试剂，以及由此获得的分化的少突胶质细胞在治疗诸如多发性硬化（MS） ）。 本发明还涉及由此获得的OLP和少突胶质细胞用于药物筛选的用途。

公开(公告)号：US20090087434A1

公开(公告)日：2009-04-02

申请号：US12234366

申请日：2008-09-19

Applicant: David J. Anderson ,  Ben Deneen ,  Hae-Ri Song

Inventor： David J. Anderson ,  Ben Deneen ,  Hae-Ri Song

IPC: A61K39/395 ,  C12N5/06 ,  C07H21/00 ,  A61K31/7088

CPC classification number: A61K31/7088 ,  C12N15/113 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53

Abstract: Disclosed herein are compositions comprising NFIA inhibitors, as well as methods of using the same to treat glioma and astrocytomas.

Abstract translation: 本文公开了包含NFIA抑制剂的组合物，以及使用其来治疗神经胶质瘤和星形细胞瘤的方法。