公开(公告)号：WO2016059619A2

公开(公告)日：2016-04-21

申请号：PCT/IB2015058032

申请日：2015-10-19

Applicant: ECOLE POLYTECH

Inventor： ISAKOVA ALINA ,  DEPLANCKE BART

IPC: B01L3/00

CPC classification number: B01L3/502738 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0877 ,  B01L2400/0655

Abstract: The present invention concerns a microfluidic device for mechanically induced trapping of molecular interactions comprising at least a first unit cell and a second unit cell, each unit cell comprising - a membrane chamber comprising a membrane, - a flow channel crossing the membrane chamber and having an inlet and an outlet, and the flow channel crossing the first unit cell being different from the flow channel crossing the second unit cell. Another object of the invention is a method for isolation of specifically bound nucleic acids to target molecules on said microfluidic device followed by its recovery and identification.

Abstract translation: 本发明涉及一种用于机械诱导捕获分子相互作用的微流体装置，其包括至少第一单元电池和第二单元电池，每个单元电池包括 - 包含膜的膜室， - 与膜室交叉并具有 入口和出口，并且与第一单元电池交叉的流动通道不同于与第二单元电池交叉的流动通道。 本发明的另一个目的是将特异性结合的核酸分离到所述微流体装置上的目标分子，然后进行其恢复和鉴定。