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1.发明申请公开(公告)号：US20190002176A1
公开(公告)日：2019-01-03
申请号：US15743361
申请日：2016-08-15
Applicant: EMD Millipore Corporation
Inventor： Stephen Proulx , David DeCoste
Abstract: A device for storing, transporting and/or handling a liquid or liquids and methods for using the device are described. The device is suitable for use with sterile or aseptic liquids, particularly with large liquid volumes such as 10-1000 liters or more, and avoids the need for bags, bins and carriers commonly used for storing and transporting large volumes of liquids. The device comprises a coiled tubing. The coiled tubing can be loaded onto a spool to support the coiled tubing. The tubing can be filled, sealed, stored and transported in a more robust manner than previously achieved with bags, bins and carriers.
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公开(公告)号：US09482351B2
公开(公告)日：2016-11-01
申请号：US13972301
申请日：2013-08-21
Applicant: EMD Millipore Corporation
Inventor： Stephen Proulx , Joseph Almasian , Naren Renganath , Stephen Tingley , Martin Morrissey
IPC: A61M5/00 , F16K5/00 , A61M39/10 , A61M39/16 , A61M39/18 , A61M39/22 , F16K3/26 , F16K17/40 , F16K15/18 , F16L37/107
CPC classification number: F16K5/00 , A61M39/10 , A61M39/16 , A61M39/18 , A61M39/22 , A61M2039/1027 , A61M2039/222 , F16K3/265 , F16K13/04 , F16K15/18 , F16L37/107
Abstract: The present invention relates to a process for the sterile transfer of fluids, be they liquids or gases. It uses a presterilized device comprised of a body having a bore formed through at least a portion of its interior. Contained within the bore is a movable plunger. The body has a first and a second end. The first end contains a face designed to be attached to the upstream component. The second end is connected to a downstream component such as a filter, pipeline, sample bag and the like. The plunger has corresponding first and second ends. The first end of the plunger when it the closed position is in alignment with the face of the body which combined form a steamable surface and a sterile barrier against the environment to the rest of the interior of the body, the plunger and downstream components. The device is attached to an upstream component and the face and the first end of the plunger are steam sterilized in place.
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公开(公告)号：US20130334450A1
公开(公告)日：2013-12-19
申请号：US13972301
申请日：2013-08-21
Applicant: EMD Millipore Corporation
Inventor： Stephen Proulx , Joseph Almasian , Naren Renganath , Stephen Tingley , Martin Morrissey
IPC: F16K5/00
CPC classification number: F16K5/00 , A61M39/10 , A61M39/16 , A61M39/18 , A61M39/22 , A61M2039/1027 , A61M2039/222 , F16K3/265 , F16K13/04 , F16K15/18 , F16L37/107
Abstract: The present invention relates to a process for the sterile transfer of fluids, be they liquids or gases. It uses a presterilized device comprised of a body having a bore formed through at least a portion of its interior. Contained within the bore is a movable plunger. The body has a first and a second end. The first end contains a face designed to be attached to the upstream component. The second end is connected to a downstream component such as a filter, pipeline, sample bag and the like. The plunger has corresponding first and second ends. The first end of the plunger when it the closed position is in alignment with the face of the body which combined form a steamable surface and a sterile barrier against the environment to the rest of the interior of the body, the plunger and downstream components. The device is attached to an upstream component and the face and the first end of the plunger are steam sterilized in place.
Abstract translation: 本发明涉及一种无菌转移流体（无论是液体还是气体）的方法。 它使用由具有通过其内部的至少一部分形成的孔的主体构成的预灭菌装置。 孔内包含一个可移动的柱塞。 身体有第一和第二端。 第一端包含设计成连接到上游部件的面。 第二端连接到诸如过滤器，管道，样品袋等的下游部件。 柱塞具有相应的第一和第二端。 柱塞在其关闭位置时的第一端与主体的表面对齐，该表面组合形成一个可蒸汽表面，并且一个无菌隔离物抵抗环境的内部其余部分，柱塞和下游部件。 该装置连接到上游部件，柱塞的表面和第一端被蒸汽灭菌就位。
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4.发明公开公开(公告)号：US20230324253A1
公开(公告)日：2023-10-12
申请号：US18297085
申请日：2023-04-07
Applicant: EMD Millipore Corporation
Inventor： Brian Pereira , Stephen Proulx
CPC classification number: G01M3/3218 , B01L3/505 , B01L2300/0861
Abstract: A testing method that includes the steps of evacuating air from a container to a negative atmospheric pressure, the container being a collapsible, flexible container, and comprising at least two opposing flexible walls, wherein a surface of at least one of the walls internal to the container comprises a plurality of channels or recessed features on said at least one wall and monitoring a mass flow or a state of vacuum so as to determine the integrity of the container. The container can be of any size or conformation, with or without attached fittings.
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Patent Agency Ranking
公开(公告)号：US20150210973A1
公开(公告)日：2015-07-30
申请号：US14677670
申请日：2015-04-02
Applicant: EMD Millipore Corporation
Inventor： James E. Kelly , Joseph William Muldoon , Stephen Proulx , James Vigna
CPC classification number: C12M23/46 , C12M23/20 , C12M23/28 , C12M23/38 , C12M23/48 , C12M27/00 , C12M29/00
Abstract: The present invention is a disposable, presterilized bioreactor formed of molded plastic, having a top and body attached to each other. One or more ports are formed in the top, side and bottom of the housing. The one or more ports that are below the liquid/air interface level may be used as sampling ports, access ports for probes or drains or supply ports for liquids or gases. The bioreactor provides a direct retrofit for the existing glass or steel assembly that utilizes the existing support structures and controls. The molded design overcomes issues of discontinuity, dead spots and the like due to its fixed dimensions that are built in by the molding process. Reproducible probe and other equipment locations are guaranteed through the use of the molded port features.
Abstract translation: 本发明是由模制塑料形成的一次性预灭菌生物反应器，其具有彼此连接的顶部和主体。 一个或多个端口形成在壳体的顶部，侧面和底部。 低于液体/空气界面水平的一个或多个端口可用作采样端口，用于探针或排水口的接口或用于液体或气体的供应端口。 生物反应器为现有的玻璃或钢组件提供直接改造，利用现有的支撑结构和控制。 成型设计由于其通过模制工艺内置的固定尺寸克服了不连续性，死点等问题。 通过使用模制端口特性，可以保证可重现的探头和其他设备位置。
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公开(公告)号：US10829289B2
公开(公告)日：2020-11-10
申请号：US15743361
申请日：2016-08-15
Applicant: EMD Millipore Corporation
Inventor： Stephen Proulx , David DeCoste
Abstract: A device for storing, transporting and/or handling a liquid or liquids and methods for using the device are described. The device is suitable for use with sterile or aseptic liquids, particularly with large liquid volumes such as 10-1000 liters or more, and avoids the need for bags, bins and carriers commonly used for storing and transporting large volumes of liquids. The device comprises a coiled tubing. The coiled tubing can be loaded onto a spool to support the coiled tubing. The tubing can be filled, sealed, stored and transported in a more robust manner than previously achieved with bags, bins and carriers.
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公开(公告)号：US20180024026A1
公开(公告)日：2018-01-25
申请号：US15548019
申请日：2016-01-12
Applicant: EMD Millipore Corporation
Inventor： Stephen Proulx , Jeffrey Pearsons
IPC: G01M3/32
CPC classification number: G01M3/3218 , G01M3/3254 , G01M3/34
Abstract: A system and method for measuring integrity of flexible containers is disclosed. The system uses a low mass flow transducer to monitor the flow of fluid into the flexible container. Based on this flow rate, the existence of an orifice in the flexible container may be detected. The system also includes a second flow path to the flexible container to allow for faster fill times. Greater flow rates are achieve through the use of a second high mass flow transducer or a calibrated bypass path. These alternate paths allow greater flow rates until the flexible container is determined to be nearly full, at which point all flow passes with the low mass flow transducer.
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公开(公告)号：US12050159B2
公开(公告)日：2024-07-30
申请号：US16644109
申请日：2018-09-27
Applicant: EMD Millipore Corporation
Inventor： Brian Pereira , Stephen Proulx
CPC classification number: G01M3/3218 , B01L3/505 , B01L2300/0861
Abstract: A testing method that includes the steps of evacuating air from a container to a negative atmospheric pressure, the container being a collapsible, flexible container, and comprising at least two opposing flexible walls, wherein a surface of at least one of the walls internal to the container comprises a plurality of channels or recessed features on said at least one wall and monitoring a mass flow or a state of vacuum so as to determine the integrity of the container. The container can be of any size or conformation, with or without attached fittings.
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9.发明申请公开(公告)号：US20200209098A1
公开(公告)日：2020-07-02
申请号：US16644109
申请日：2018-09-27
Applicant: EMD Millipore Corporation
Inventor： Brian Pereira , Stephen Proulx
Abstract: A testing method that includes the steps of evacuating air from a container to a negative atmospheric pressure, the container being a collapsible, flexible container, and comprising at least two opposing flexible walls, wherein a surface of at least one of the walls internal to the container comprises a plurality of channels or recessed features on said at least one wall and monitoring a mass flow or a state of vacuum so as to determine the integrity of the container. The container can be of any size or conformation, with or without attached fittings.
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