公开(公告)号：US20150283143A1

公开(公告)日：2015-10-08

申请号：US14440395

申请日：2011-01-25

Applicant: ENDACEA, INC.

Inventor： Constance Neely Wilson

IPC: A61K31/522 ,  A61K45/06

CPC classification number: A61K31/522 ,  A61K31/519 ,  A61K31/52 ,  A61K45/06

Abstract: The present invention relates to methods for treating and preventing renal impairment by administering to a subject a therapeutically effective amount of an A1 adenosine receptor antagonist alone or in combination with at least one additional therapeutic agent. The invention further encompasses pharmaceutical compositions comprising an A1 adenosine receptor antagonist alone or with, at least, one additional therapeutic agent in a pharmaceutically acceptable carrier. The pharmaceutical compositions of the invention find use in methods for treating and preventing renal impairment.

Abstract translation: 本发明涉及通过向受试者施用治疗有效量的单独的或与至少一种另外的治疗剂组合的A1腺苷受体拮抗剂来治疗和预防肾损伤的方法。 本发明还包括药物组合物，其单独或与药学上可接受的载体中的至少一种另外的治疗剂单独包含A1腺苷受体拮抗剂。 本发明的药物组合物可用于治疗和预防肾损伤的方法。