公开(公告)号：US20230023196A1

公开(公告)日：2023-01-26

申请号：US17871579

申请日：2022-07-22

Applicant: ENTEGRIS, INC.

Inventor： Nicholas Coscia

IPC: A01N1/02 ,  F25D29/00 ,  B01L9/00

Abstract: A bag holder for supporting a bioprocess bag during freezing includes a cover, a bottom, a frame, and at least one bag support. The cover, the bottom, and the frame form an enclosed space. The at least one bag support is disposed in the space. The cover and the bottom are made of metal. The frame has a first side, a second side, a front end, and a back end. Each of the cover and the bottom has a first bendable tab and a second bendable tab configured to bend over the front end from a longitudinal direction to a thickness direction, and a first arm and a second arm extending in the thickness direction and then in the longitudinal direction. Each of the first side and the second side includes at least one recessed portion extending in the longitudinal direction.

公开(公告)号：US12116169B2

公开(公告)日：2024-10-15

申请号：US18100493

申请日：2023-01-23

Applicant: ENTEGRIS, INC.

Inventor： Nicholas Coscia

IPC: B65D47/06 ,  B65D25/48 ,  B65D47/24 ,  B67C3/04 ,  B65D47/32

CPC classification number: B65D25/48 ,  B65D47/061 ,  B65D47/248 ,  B67C3/04 ,  B65D47/32

Abstract: An aseptic closure assembly for a fluid container that includes a cap connectable to an opening of the fluid container and a fluid dispenser connectable to an outer surface of the housing of the cap. The fluid dispenser includes a main body and fluid lines provided within the main body, a shell housing provided around the main body, and an insert connectable to a second end of the main body. The main body includes apertures nearer the second end that are connected to the fluid lines and configured to be in fluid communication with the fluid container when the fluid dispenser is connected to the cap. The fluid dispenser is configured such that a downward directed force towards the fluid container fits the insert into the support of the cavity and disconnects the insert from the main body of the fluid dispenser to seal the fluid container.

公开(公告)号：US20230064103A1

公开(公告)日：2023-03-02

申请号：US17894905

申请日：2022-08-24

Applicant: ENTEGRIS, INC.

Inventor： Nicholas Coscia

IPC: B04B11/04 ,  B01L3/00 ,  B04B5/04

Abstract: A transfer container for a fluid includes a tube, the tube including a conical portion at one end, the tube defining an interior space and one or more fluid passages configured to allow flow of fluid into or out of the interior space of the tube. The transfer container also includes a connector configured to seal the end of the conical portion when the connector is joined only to the conical portion and a pressure control mechanism configured to increase or decrease a pressure in the interior space of the tube. The transfer container can be used in a method including connecting fluid lines to the fluid passages, adding a fluid including cryoprotectant and cells, centrifuging the transfer container, and then connecting the transfer container to a second fluid transfer container containing another fluid. This allows the sterile transfer of fluids and separation of cells from cryoprotectant.

公开(公告)号：USD1015569S1

公开(公告)日：2024-02-20

申请号：US29774971

申请日：2021-03-19

Applicant: ENTEGRIS, INC.

Designer： Nicholas Coscia

Abstract: FIG. 1 is a top-front-left perspective view of a bag holding tray showing my new design;
FIG. 2 is an enlarged view of area 2 encircled in FIG. 1;
FIG. 3 is an enlarged view of area 3 encircled in FIG. 1;
FIG. 4 is a top-rear-right perspective view of the bag holding tray;
FIG. 5 is an enlarged view of area 5 encircled in FIG. 4;
FIG. 6 is an enlarged view of area 6 encircled in FIG. 4;
FIG. 7 is a bottom-front-left perspective view of the bag holding tray;
FIG. 8 is an enlarged view of area 8 encircled in FIG. 7;
FIG. 9 is a bottom-rear-right perspective view of the bag holding tray;
FIG. 10 is an enlarged view of area 10 encircled in FIG. 9;
FIG. 11 is an enlarged view of area 11 encircled in FIG. 9;
FIG. 12 is a top view of the bag holding tray;
FIG. 13 is an enlarged view of area 13 encircled in FIG. 12;
FIG. 14 is a bottom view of the bag holding tray;
FIG. 15 is an enlarged view of area 15 encircled in FIG. 6A;
FIG. 16 is an enlarged view of area 16 encircled in FIG. 14;
FIG. 17 is a front view of the bag holding tray;
FIG. 18 is an enlarged view of area 18 encircled in FIG. 17;
FIG. 19 is a rear view of the bag holding tray;
FIG. 20 is an enlarged view of area 20 encircled in FIG. 19;
FIG. 21 is a left side view of the bag holding tray; and,
FIG. 22 is an enlarged view of area 22 encircled in FIG. 21.
The broken lines in the drawings depict portions of the bag holding tray that form no part of the claimed design.

公开(公告)号：USD1011551S1

公开(公告)日：2024-01-16

申请号：US29774988

申请日：2021-03-19

Applicant: ENTEGRIS, INC.

Designer： Nicholas Coscia

Abstract: FIG. 1 is a top-front-left perspective view of a bag holding tray showing my new design;
FIG. 2 is an enlarged view of area 2 encircled in FIG. 1;
FIG. 3 is an enlarged view of area 3 encircled in FIG. 1;
FIG. 4 is a top-front-right perspective view of the bag holding tray;
FIG. 5 is an enlarged view of area 5 encircled in FIG. 4;
FIG. 6 is an enlarged view of area 6 encircled in FIG. 4;
FIG. 7 is a bottom-rear-left perspective view of the bag holding tray;
FIG. 8 is an enlarged view of area 8 encircled in FIG. 7;
FIG. 9 is a bottom-rear-right perspective view of the bag holding tray;
FIG. 10 is an enlarged view of area 10 encircled in FIG. 9;
FIG. 11 is an enlarged view of area 11 encircled in FIG. 9;
FIG. 12 is a top view of the bag holding tray;
FIG. 13 is an enlarged view of area 13 encircled in FIG. 12;
FIG. 14 is an enlarged view of area 14 encircled in FIG. 12;
FIG. 15 is a bottom view of the bag holding tray;
FIG. 16 is an enlarged view of area 16 encircled in FIG. 15;
FIG. 17 is an enlarged view of area 17 encircled in FIG. 15;
FIG. 18 is a front view of the bag holding tray;
FIG. 19 is an enlarged view of area 19 encircled in FIG. 18;
FIG. 20 is a rear view of the bag holding tray;
FIG. 21 is an enlarged view of area 21 encircled in FIG. 20;
FIG. 22 is a left side view of the bag holding tray; and,
FIG. 23 is an enlarged view of area 23 encircled in FIG. 22.
The broken lines in the drawings depict portions of the bag holding tray that form no part of the claimed design.
The dot-dot-dash broken lines depict the boundaries of the claim and form no part thereof.

公开(公告)号：US20230122990A1

公开(公告)日：2023-04-20

申请号：US17827470

申请日：2022-05-27

Applicant: ENTEGRIS, INC.

Inventor： Nicholas Coscia ,  Muhammad Siddiqui ,  Tate Vangsgard

IPC: A61M39/18 ,  A61J1/05

Abstract: A bag assembly that includes a bag portion having first and second walls defining an interior and an opening. The interior is formed by the first and second walls of the bag portion being attached to each other along at least a portion of a perimeter of the bag assembly up to one end of the bag portion. Portions of the first and second walls of the bag portion that are not attached to each other form the opening. The bag assembly also includes an aseptic system for sterile connection and disconnection of the bag assembly from a sterile process, the aseptic system being continuously formed at an interface between the aseptic system and the one end of the bag portion. The aseptic system includes an internal passage to allow fluid communication with the interior of the bag portion and the sterile process.

公开(公告)号：US20220295784A1

公开(公告)日：2022-09-22

申请号：US17698207

申请日：2022-03-18

Applicant: ENTEGRIS, INC.

Inventor： Nicholas Coscia

IPC: A01N1/02 ,  A61J1/16

Abstract: A bag holder for a blast freezing process includes a bag tray. The bag tray is genderless and can be combined with an identical bag tray to form the bag holder. The bag holder includes a basin, side walls, and an end wall. The first and second side walls each include a set of alternating extended and recessed sections and a channel extending through at least a portion of the set of alternating extended and recessed sections. The alternating extended and recessed sections are offset from one another such that where a set on one side wall has an extended section, the set on the other side wall has a recessed section and vice versa. Methods include forming these bag trays, and placing a bag in one bag tray, then joining another bag tray to form the holder around the bag.

公开(公告)号：US11815211B2

公开(公告)日：2023-11-14

申请号：US17827423

申请日：2022-05-27

Applicant: ENTEGRIS, INC.

Inventor： Nicholas Coscia

IPC: F16L37/098 ,  F16L37/30 ,  A61M39/18 ,  A61M39/10

CPC classification number: F16L37/098 ,  A61M39/18 ,  F16L37/30 ,  A61M2039/1027 ,  F16L2201/44

Abstract: An aseptic low-temperature coupling assembly includes a first connector, a second connector, and a gasket disposed in the first or the second connector. The first and second connectors include a first retaining feature and a second retaining feature configured to couple together the first and the second connectors and align openings in the first and second connectors. The gasket is formed to have no substantial deformation after being cooled to at least −50° C. then heated to ambient temperature. A method of aseptically connecting a low-temperature fluid storage container includes coupling a first connector to a second connector via first retaining features and second retaining features of the connectors. The coupling compresses a gasket between the first connector and the second connector and aligns an opening in the first connector with an opening in the second connector.

公开(公告)号：US20230234823A1

公开(公告)日：2023-07-27

申请号：US18100493

申请日：2023-01-23

Applicant: ENTEGRIS, INC.

Inventor： Nicholas Coscia

IPC: B67C3/04

CPC classification number: B67C3/04

Abstract: An aseptic closure assembly for a fluid container that includes a cap connectable to an opening of the fluid container and a fluid dispenser connectable to an outer surface of the housing of the cap. The fluid dispenser includes a main body and fluid lines provided within the main body, a shell housing provided around the main body, and an insert connectable to a second end of the main body. The main body includes apertures nearer the second end that are connected to the fluid lines and configured to be in fluid communication with the fluid container when the fluid dispenser is connected to the cap. The fluid dispenser is configured such that a downward directed force towards the fluid container fits the insert into the support of the cavity and disconnects the insert from the main body of the fluid dispenser to seal the fluid container.

公开(公告)号：US20230213129A1

公开(公告)日：2023-07-06

申请号：US18090791

申请日：2022-12-29

Applicant: ENTEGRIS, INC.

Inventor： Jacob Peabody ,  Nicholas Coscia ,  David Schroeder ,  Tate Vangsgard

IPC: F16L37/35 ,  F16L37/084

CPC classification number: F16L37/35 ,  F16L37/0841 ,  F16L2201/44

Abstract: An aseptic coupling assembly, includes a first connector and a second connector. The first connector includes a first housing, a first valve member, and a first spring that biases the first valve member towards the second end of the first housing to a first closed position. The second connector includes a second housing, a second valve member, and a second spring that biases the second valve member towards the second end of the second housing to a second closed position. The first valve member is slidable away from the first closed position within the first housing to compress the first spring and the second valve member is slidable away from the second closed position within the second housing to compress the second spring. The coupling assembly further includes a seal that prevents fluid from contacting the first spring and the second spring.