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公开(公告)号:US20150257810A1
公开(公告)日:2015-09-17
申请号:US14715092
申请日:2015-05-18
Applicant: Endocare, Inc.
Inventor: John M. Baust , Claudia Luekge , Roy Cheeks , John G. Baust , Anthony T. Robilotto
IPC: A61B18/02
CPC classification number: A61B18/02 , A61B2017/00084 , A61B2017/003 , A61B2018/00202 , A61B2018/00208 , A61B2018/00577 , A61B2018/00797 , A61B2018/0212
Abstract: One embodiment of the invention is a flexible cryogenic probe tip. The flexible probe tip has a linear freeze zone at a distal end of the probe that allows for its placement and precisely controlled movements. The flexible cryogenic probe tip precisely conforms to the target tissue surface to create a linear lesion. In addition, the probe tip is steerable to facilitate proper placement with minimal access points into a patient's body. Various configurations of the flexible probe tip allow it to conform and ablate tissue of many sizes, shapes, and/or dimensions. Methods of utilizing the cryogenic probe tip include steps of positioning the distal end at a tissue site for at least one ablative procedure, maneuvering the distal end to the tissue site, directing a cryogen from the supply source to the distal end, controlling a flow of cryogen from the supply source to the distal end and back to the supply source, and segmenting control of the distal end mechanically or through the step of controlling the flow of cryogen.
Abstract translation: 本发明的一个实施例是柔性低温探针尖端。 柔性探针尖端在探头的远端具有允许其放置和精确控制运动的线性冻结区。 柔性低温探针尖端精确地符合目标组织表面以产生线性损伤。 此外,探针尖是可操纵的,以便于以最小的接入点进入患者身体的正确放置。 柔性探针尖端的各种构造允许其适应并消融许多尺寸,形状和/或尺寸的组织。 使用低温探针尖端的方法包括以下步骤:将远端定位在组织部位处至少一个烧蚀程序,将远端操纵到组织部位,将冷冻剂从供应源引导到远端,控制流动 冷冻剂从供应源到远端并返回到供应源,并且机械地或通过控制冷冻剂流动的步骤来分段远端的控制。
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公开(公告)号:US20200030018A1
公开(公告)日:2020-01-30
申请号:US16593914
申请日:2019-10-04
Applicant: Endocare, Inc.
Inventor: John M. Baust , Claudia Lueckge , Roy Cheeks , John G. Baust , Anthony T. Robi
IPC: A61B18/02
Abstract: An ablation instrument having a longitudinal body with a plurality of sidewalls that form a flexible sleeve, where the plurality of sidewalls that form the flexible sleeve are slotless. The longitudinal body has a proximal end, a distal end, and a central axis. A luminary space is formed within the plurality of sidewalls and at least one internal component is inserted through the proximal end of the longitudinal body and extends through the luminary space to the distal end. The internal component is interconnected with a deflection mechanism for controlling the distal end of the longitudinal body such that the distal end is capable of multi-planar movement.
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公开(公告)号:US09974592B2
公开(公告)日:2018-05-22
申请号:US14808750
申请日:2015-07-24
Applicant: Endocare, Inc.
Inventor: John M. Baust , John G. Baust , Roy E. Cheeks , Melissa K. Dobson , Anthony T. Robilotto , Kristi K. Snyder , Robert G. Van Buskirk
CPC classification number: A61B18/02 , A61B2018/00041 , A61B2018/00357 , A61B2018/00577 , A61B2018/00791 , A61B2018/00863 , A61B2018/00982 , A61B2018/00994 , A61B2018/0212 , A61B2018/0262 , F04C2270/0421
Abstract: Cryogenic medical devices and apparatus are disclosed which are capable of generating cryogen to a supercritical state, specifically supercritical nitrogen. The cryogenic medical devices and apparatus disclosed are useful in methods of treating damaged, diseased, cancerous or other unwanted tissues.
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公开(公告)号:US20170172791A1
公开(公告)日:2017-06-22
申请号:US15445968
申请日:2017-02-28
Applicant: Endocare, Inc.
Inventor: John M. Baust , Roy E. Cheeks , John G. Baust , Anthony Robilotto , Kristi K. Snyder
CPC classification number: A61F7/12 , A61B5/0084 , A61B5/01 , A61B5/036 , A61B5/0422 , A61B18/02 , A61B2017/00084 , A61B2017/22051 , A61B2018/00041 , A61B2018/00101 , A61B2018/0022 , A61B2018/00982 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , A61B2090/064 , A61F7/123 , A61F2007/0056
Abstract: A cryogenic medical device for delivery of subcooled liquid cryogen to various configurations of cryoprobes is designed for the treatment of damaged, diseased, cancerous or other unwanted tissues. The device is a closed or semi-closed system in which the liquid cryogen is contained in both the supply and return stages. The device is capable of generating cryogen to a supercritical state and may be utilized in any rapid cooling systems. As designed, the device comprises a number of parts including a vacuum insulated outer dewar, submersible cryogen pump, baffled linear heat exchanger, multiple pressurization cartridges, a return chamber, and a series of valves to control the flow of the liquid cryogen interconnected with cryotreatment devices including cryoprobes and catheters. The cryogenic medical device promotes subcooling to the tips of various external cryogenic instrument configurations.
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公开(公告)号:US11026737B2
公开(公告)日:2021-06-08
申请号:US14213441
申请日:2014-03-14
Applicant: ENDOCARE, INC.
Inventor: John G. Baust , John M. Baust , Anthony T. Robilotto
Abstract: Embodiments of the present invention relate to cryogenic systems and methods useful to cool objects, including living tissue, to freezing or cryogenic temperatures by placing the object in thermal communication with sub-cooled supercritical nitrogen.
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公开(公告)号:US20170224401A1
公开(公告)日:2017-08-10
申请号:US15581218
申请日:2017-04-28
Applicant: Endocare, Inc.
Inventor: John M. Baust , John G. Baust , Roy E. Cheeks , Anthony Robilotto
CPC classification number: A61B18/02 , A61B17/29 , A61B18/1445 , A61B2017/00212 , A61B2017/00398 , A61B2017/00539 , A61B2017/00544 , A61B2017/2932 , A61B2018/00101 , A61B2018/00714 , A61B2018/00791 , A61B2018/00839 , A61B2018/0212 , A61B2018/0225 , A61B2018/0262 , A61B2090/064 , A61B2090/0811
Abstract: A cryogenic medical device is disclosed for use in minimally invasive surgical procedures. Various configurations of cryoprobes are designed in combination with a clamp to form a cryoclamp for the treatment of damaged, diseased, cancerous or other unwanted tissues. The device is an integrated cryoablation probe with a hinged clamp that allows for single entry into the chest cavity through a thorascopic port, by surgical or other means. The integrated cryoablation probe allows for the clamping of tissue as well as freezing with a single device. The clamp acts as an outer sheath so that when closed, directional freezing of the cryoprobe is achieved on the opposing probe surface away from the clamp or on an internal surface that is between the clamp. The cryoclamp may be a removable attachment or integrated into the unitary device.
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公开(公告)号:US20140350537A1
公开(公告)日:2014-11-27
申请号:US14213441
申请日:2014-03-14
Applicant: ENDOCARE, INC.
Inventor: John G. Baust , John M. Baust , Anthony T. Robilotto
IPC: A61B18/02
CPC classification number: A61B18/02 , A61B2018/00023 , A61B2018/00577 , A61B2018/0212 , A61B2018/0262 , A61B2018/0293
Abstract: Embodiments of the present invention relate to cryogenic systems and methods useful to cool objects, including living tissue, to freezing or cryogenic temperatures by placing the object in thermal communication with sub-cooled supercritical nitrogen.
Abstract translation: 本发明的实施方案涉及通过将物体与次冷的超临界氮热连通来将低温系统和方法用于将物体(包括活组织)冷却至冷冻或低温的温度。
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公开(公告)号:US11963707B2
公开(公告)日:2024-04-23
申请号:US16687651
申请日:2019-11-18
Applicant: Endocare, Inc.
Inventor: John M. Baust , John G. Baust , Roy Cheeks , Anthony Robilotto , Kristi Snyder
CPC classification number: A61B18/02 , F17C9/00 , F17C9/02 , F25B19/005 , F25D3/00 , F25D19/00 , A61B2018/0212 , A61B2018/0262 , F17C2223/013 , F17C2270/02 , F25B2400/01 , F25D2400/02
Abstract: A cryogenic medical device for delivery of subcooled liquid cryogen to various configurations of cryoprobes is designed for the treatment of damaged, diseased, cancerous or other unwanted tissues. The device is a closed or semi-closed system in which the liquid cryogen is contained in both the supply and return stages. The device is capable of generating cryogen to a supercritical state and may be utilized in any rapid cooling systems. As designed, the device comprises a number of parts including a vacuum insulated outer dewar, submersible cryogen pump, baffled linear heat exchanger, multiple pressurization cartridges, a return chamber, and a series of valves to control the flow of the liquid cryogen. The cryogenic medical device promotes the subcooling to any external cryogenic instrument.
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公开(公告)号:US20150338008A1
公开(公告)日:2015-11-26
申请号:US14814437
申请日:2015-07-30
Applicant: Endocare, Inc.
Inventor: John M. Baust , Claudia Luekge , Roy Cheeks , Melisa K. Dobson , Anthony T. Robilotto
CPC classification number: F16L39/00 , A61B18/02 , A61B2018/00172 , F16L13/103 , F16L15/00 , F16L25/01 , F16L37/00 , F16L2201/44 , F17C7/02
Abstract: An embodiment of the invention is a cryo-connector, a connector that allows for the delivery and return of a cryogen in an axial configuration. In one embodiment, the connector is a tri-axial configuration allowing for the delivery and return of pressurized cryogen as well as the application of an independent vacuum in the third lumen. Various configurations, however, may accommodate any number of luminary spaces such that cryogen (or other fluids) and/or vacuum spaces may be created in a fashion complementary to the components that the connector will affix to and interconnect with. The connectors can be utilized with any low temperature, cryogenic device and at varying pressures.
Abstract translation: 本发明的一个实施例是一种冷冻连接器,一种允许在轴向配置中输送和返回冷冻剂的连接器。 在一个实施例中,连接器是允许加压制冷剂的输送和返回以及在第三管腔中施加独立真空的三轴构造。 然而,各种配置可以容纳任何数量的发光空间,使得制冷剂(或其它流体)和/或真空空间可以以与连接器将固定到其上并与之相互连接的部件互补的方式产生。 连接器可以与任何低温,低温装置和变化的压力一起使用。
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公开(公告)号:US20150018810A1
公开(公告)日:2015-01-15
申请号:US14336317
申请日:2014-07-21
Applicant: Endocare, Inc.
Inventor: John M. Baust , Roy E. Cheeks , John G. Baust , Anthony Robilotto , Kristi K. Snyder
CPC classification number: A61B18/0218 , A61B18/02 , A61B2018/0022 , A61B2018/0212 , A61B2018/0268 , F17C9/00
Abstract: A cryogenic medical device for delivery of subcooled liquid cryogen to various configurations of cryoprobes is designed for the treatment of damaged, diseased, cancerous or other unwanted tissues. The device is a closed or semi-closed system in which the liquid cryogen is contained in both the supply and return stages. The device is capable of generating cryogen to a supercritical state and may be utilized in any rapid cooling systems. As designed, the device comprises a number of parts including a vacuum insulated outer dewar, submersible cryogen pump, baffled linear heat exchanger, multiple pressurization cartridges, a return chamber, and a series of valves to control the flow of the liquid cryogen interconnected with cryotreatment devices including cryoprobes and catheters. The cryogenic medical device promotes subcooling to the tips of various external cryogenic instrument configurations.
Abstract translation: 用于将过冷液体冷冻剂递送到各种构造的低温球的低温医疗装置被设计用于治疗受损害的,患病的,癌性的或其它不想要的组织。 该装置是封闭或半封闭的系统,其中液体冷冻剂包含在供应和返回阶段。 该装置能够将冷冻剂生成超临界状态,并可用于任何快速冷却系统。 根据设计,该装置包括多个部件,包括真空绝缘的外部杜瓦瓶,潜水式低温泵,挡板式线性热交换器,多个加压筒,回流室和一系列阀门,以控制与冷冻处理相互连接的液体冷冻剂的流动 装置包括冷冻探针和导管。 低温医疗装置促进对各种外部低温仪器配置的尖端的过冷。
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