公开(公告)号：WO2017041102A1

公开(公告)日：2017-03-09

申请号：PCT/US2016/050415

申请日：2016-09-06

Applicant: FLODESIGN SONICS, INC.

Inventor： GILMANSHIN, Rudolf ,  LIPKENS, Bart ,  DUTRA, Brian ,  KENNEDY, Daniel

IPC: A61M1/36 ,  B01D21/28 ,  B06B1/06

CPC classification number: A61M1/3678 ,  A61M1/3692 ,  A61M2202/0427 ,  A61M2202/0429 ,  A61M2202/0456 ,  A61M2202/08 ,  A61M2205/0244 ,  B06B1/0674

Abstract: Acoustophoretic devices are disclosed. The devices include a flow chamber, an ultrasonic transducer, a reflector, an inlet, a filtrate outlet, a concentrate outlet, and optionally a lipid collection trap. The ultrasonic transducer and reflector create a multi-dimensional acoustic standing wave in the flow chamber that traps and separates red blood cells and/or lipids from blood. Concentrated red blood cells can be recovered via the concentrate outlet, the lipids can be recovered via the lipid collection trap, and the remaining blood can be recovered via the filtrate outlet. Methods for separating blood components (e.g., red blood cells, lipids, platelets, white blood cells) from blood are also disclosed. The red blood cells can undergo washing with a solvent to remove undesired admixtures. Cryoprotectants can be added or removed from the blood.

Abstract translation: 公开了声学设备。 这些装置包括流动室，超声换能器，反射器，入口，滤液出口，浓缩物出口和任选的脂质收集阱。 超声波换能器和反射器在流动室中产生多维声驻波，其将红细胞和/或血液从血液中捕获和分离。 可以通过浓缩物出口回收浓缩的红细胞，通过脂质收集阱可以回收脂质，剩余的血液可以通过滤液出口回收。 还公开了从血液中分离血液成分（例如红细胞，脂质，血小板，白细胞）的方法。 红细胞可以用溶剂洗涤以除去不想要的混合物。 可以从血液中加入或除去冷冻保护剂。