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Patent Agency Ranking
公开(公告)号：WO2016176663A1
公开(公告)日：2016-11-03
申请号：PCT/US2016/030315
申请日：2016-04-29
Applicant: FLODESIGN SONICS, INC.
Inventor： LIPKENS, Bart , PRESZ, Walter M. Jr. , CHITALE, Kedar , KENNEDY, Thomas J. III
CPC classification number: C12N13/00 , A61M1/3678 , B01D21/283 , B01L3/502761 , B01L2300/0864 , B01L2300/0867 , B01L2400/0436 , B01L2400/0439 , C12M47/04 , G01N15/1484 , G01N2015/0053 , G01N2015/1006 , G01N2015/149
Abstract: Devices for separating materials from a host fluid are disclosed. The devices 100 include a flow chamber, an ultrasonic transducer 120, and a reflector 130. The ultrasonic transducer 120 and reflector 130 create an angled acoustic standing wave oriented at an angle A relative to the direction of mean flow 116 through the flow chamber. The angled acoustic standing wave 122 results in an acoustic radiation force having an axial force component that deflects the materials, so that the materials and the host fluid can thus be separated. The angled acoustic standing wave can be oriented at an angle of about 20° to about 70° relative to the direction of mean flow through the flow chamber to deflect, collect, differentiate, or fractionate the materials from the fluid flowing through the device at flow rates of about 400 mL/min up to about 700 mL/min.
Abstract translation: 公开了用于从主体流体分离材料的装置。 装置100包括流动室，超声波换能器120和反射器130.超声波换能器120和反射器130产生相对于通过流动室的平均流动方向116以角度A定向的倾斜声驻波。 倾斜的声驻波122导致具有使材料偏转的轴向力分量的声辐射力，从而可以分离材料和主流体。 倾斜的声驻波可以相对于通过流动室的平均流动的方向以大约20°至大约70°的角度定向，从而偏离，收集，分离或分流材料与流过流过装置的流体 速率约400mL / min，高达约700mL / min。
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公开(公告)号：WO2016100923A1
公开(公告)日：2016-06-23
申请号：PCT/US2015/066884
申请日：2015-12-18
Applicant: FLODESIGN SONICS, INC.
Inventor： LIPKENS, Bart , MILLER, Erik , ROSS-JOHNSRUD, Benjamin , PRESZ, Walter M. Jr. , CHITALE, Kedar , KENNEDY, Thomas J. III
Abstract: Acoustic perfusion devices for separating biological cells from other material in a fluid medium are disclosed. The devices include an inlet port, an outlet port, and a collection port that are connected to an acoustic chamber. An ultrasonic transducer creates an acoustic standing wave in the acoustic chamber that permits a continuous flow of fluid to be recovered through the collection port while keeping the biological cells within the acoustic chamber to be returned to the bioreactor from which the fluid medium is being drawn.
Abstract translation: 公开了用于将流体介质中的生物细胞与其它材料分离的声学灌注装置。 这些装置包括连接到声学室的入口端口，出口端口和收集端口。 超声波换能器在声学室中产生声驻波，允许流体通过收集口连续流动，同时将声室内的生物细胞保持回流到生物反应器，流体介质从该反应器被拉出。
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公开(公告)号：EP3234099A1
公开(公告)日：2017-10-25
申请号：EP15825713.9
申请日：2015-12-18
Applicant: Flodesign Sonics Inc.
Inventor： LIPKENS, Bart , MILLER, Erik , ROSS-JOHNSRUD, Benjamin , PRESZ, Walter M. Jr. , CHITALE, Kedar , KENNEDY, Thomas J. III
Abstract: Acoustic perfusion devices for separating biological cells from other material in a fluid medium are disclosed. The devices include an inlet port, an outlet port, and a collection port that are connected to an acoustic chamber. An ultrasonic transducer creates an acoustic standing wave in the acoustic chamber that permits a continuous flow of fluid to be recovered through the collection port while keeping the biological cells within the acoustic chamber to be returned to the bioreactor from which the fluid medium is being drawn.
Abstract translation: 公开了用于从流体介质中的其他材料分离生物细胞的声灌注装置。 这些装置包括连接到声室的入口端口，出口端口和收集端口。 超声换能器在声室中产生声驻波，其允许流体的连续流动通过采集端口被回收，同时保持声室内的生物细胞返回到流体介质从其中被抽出的生物反应器。
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公开(公告)号：EP3234099B1
公开(公告)日：2020-06-03
申请号：EP15825713.9
申请日：2015-12-18
Applicant: Flodesign Sonics, Inc.
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公开(公告)号：EP3288660A1
公开(公告)日：2018-03-07
申请号：EP16732365.8
申请日：2016-04-29
Applicant: Flodesign Sonics Inc.
Inventor： LIPKENS, Bart , PRESZ, Walter M. Jr. , CHITALE, Kedar , KENNEDY, Thomas J. III , ROSS-JOHNSRUD, Ben
CPC classification number: C12N13/00 , A61M1/3678 , B01D21/283 , B01L3/502761 , B01L2300/0864 , B01L2300/0867 , B01L2400/0436 , B01L2400/0439 , C12M47/04 , G01N15/1484 , G01N2015/0053 , G01N2015/1006 , G01N2015/149
Abstract: Devices for separating materials from a host fluid are disclosed. The devices include a flow chamber, an ultrasonic transducer, and a reflector. The ultrasonic transducer and reflector create an angled acoustic standing wave oriented at an angle relative to the direction of mean flow through the flow chamber. The angled acoustic standing wave results in an acoustic radiation force having an axial force component that deflects the materials, so that the materials and the host fluid can thus be separated. The angled acoustic standing wave can be oriented at an angle of about 20° to about 70° relative to the direction of mean flow through the flow chamber to deflect, collect, differentiate, or fractionate the materials from the fluid flowing through the device at flow rates of about 400 mL/min up to about 700 mL/min.
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