公开(公告)号：WO1989004632A1

公开(公告)日：1989-06-01

申请号：PCT/US1988003978

申请日：1988-11-08

Applicant: FLORIDA INTERNATIONAL UNIVERSITY

Inventor： FLORIDA INTERNATIONAL UNIVERSITY ,  HAGMANN, Mark, J. ,  BABIJ, Tadeusz, M.

IPC: A61B05/05

CPC classification number: A61B5/05

Abstract: A detector (14, 15, 22, 60 or 90) for detecting high frequency current (I) includes a high resistivity coil (26) wound around a nonferromagnetic core (34). The ratio of the coil (26) spacing to the cross sectional area of the coil (26) is maintained constant over the length of the coil (26). A high resistivity material shield (36) surrounds and is spaced from the coil (26) and has a gap (38) oriented along an azimuth of the closed loop winding and directed orthogonal to the net current direction of the current induced in the coil (26). The ends of the coil (26) are coupled to a high impedance voltage detector (24) through high resistivity leads (46 and 48) and a resistor (52) is coupled between the leads (46 and 48) to reduce the quality factor. The current detector (14, 15, 22, 60 or 90) may be used to detect current (I) flowing in a human body (10) due to the absorption of high frequency incident radiation as an indication of the specific absorption rate of such radiation.

Abstract translation: 用于检测高频电流（I）的检测器（14,15,22,60或90）包括缠绕在非铁磁芯（34）上的高电阻线圈（26）。 线圈（26）间隔与线圈（26）的横截面积的比率在线圈（26）的长度上保持恒定。 高电阻率材料屏蔽（36）围绕并与线圈（26）隔开并且具有沿着闭环绕组的方位取向的间隙（38），并且与线圈中感应的电流的净电流方向垂直 26）。 线圈（26）的端部通过高电阻率引线（46和48）耦合到高阻抗电压检测器（24），并且电阻器（52）耦合在引线（46和48）之间以降低品质因数。 电流检测器（14,15,22,60或90）可用于检测由于高频入射辐射的吸收而引起的人体（10）中流动的电流（I），作为此类吸收速率的指示 辐射。

公开(公告)号：WO1997019054A1

公开(公告)日：1997-05-29

申请号：PCT/US1996018570

申请日：1996-11-15

Applicant: FLORIDA INTERNATIONAL UNIVERSITY ,  BECKER, David, A.

Inventor： FLORIDA INTERNATIONAL UNIVERSITY

IPC: C07C251/14

CPC classification number: C07C291/02 ,  C07C291/04 ,  C07C2602/30

Abstract: The present invention relates to chromotropic nitrone spin trapping agents, methods of making these agents, compositions comprising same, and methods of their use. In particular, azulenyl nitrones of the present invention are effective agents for trapping free radical species and find use as efficient antioxidants in physicochemical and biological systems. Accordingly, the invention also relates to spin adducts formed from the combination of azulenyl nitrones with free radicals. The compounds of the present invention are readily prepared from available starting materials and find further use in assays and in a number of diagnostic, prophylactic and therapeutic applications, including but not limited to the alleviation, modulation and inhibition of the negative effects of carbon-centered or oxygen-centered radical species and other products of oxidation. Moreover, the combination adducts may be colorimetrically detected and, optionally, isolated and characterized to obtain valuable information (e.g., structural and the like) about the original reactive free radical species.

Abstract translation: 本发明涉及发色性硝酮自旋捕获剂，制备这些试剂的方法，包含它们的组合物及其使用方法。 特别地，本发明的薁基硝酸盐是捕获自由基物质的有效试剂，可用作物理化学和生物体系中的有效抗氧化剂。 因此，本发明还涉及由薁基硝酮与自由基的组合形成的旋转加合物。 本发明的化合物可以容易地从可得到的起始原料制备，并进一步用于测定和许多诊断，预防和治疗应用，包括但不限于缓解，调节和抑制碳中心的负面作用 或氧中心的自由基物质和其他氧化产物。 此外，可以比色测定组合加合物，并且任选地分离和表征组合加合物以获得有关初始反应性自由基物质的有价值的信息（例如结构等）。

公开(公告)号：WO1989010086A1

公开(公告)日：1989-11-02

申请号：PCT/US1989001605

申请日：1989-04-17

Applicant: FLORIDA INTERNATIONAL UNIVERSITY

Inventor： FLORIDA INTERNATIONAL UNIVERSITY ,  HAGMANN, Mark, J. ,  BABIJ, Tadeusz, M.

IPC: A61B05/00

CPC classification number: A61B5/01 ,  A61B5/05 ,  G01R29/0878 ,  H01Q9/16 ,  H01Q21/24

Abstract: A probe (18), inserted into a tumor (14) undergoing hyperthermia treatment, is designed to isotropically measure the electric field (Ex, Ey, Ez) and temperature in the tumor (14). The probe (18) is constructed on a triangular prism (30) and includes a dipole (44, 46 and 48) on each prism face (36, 38 and 40) oriented at an angle of 54.74 DEG . Each dipole (44, 46 and 48) includes rectifier means (50, 52 and 54) and the dipoles (44, 46 and 48) are coupled serially to a high input impedance voltage meter (24) using high resistivity leads (58, 64, 70 and 74). Two thermistors (76 and 78) are coupled between the three dipoles (44, 46 and 48), and high resistance lead means (80, 82, 84 and 86) couple the thermistors to separate meters (26 and 28).

Abstract translation: 插入到进行热疗处理的肿瘤（14）中的探针（18）设计成各向同性地测量肿瘤中的电场（Ex，Ey，Ez）和温度（14）。 探针（18）构造在三角棱镜（30）上，并且在每个棱镜面（36,38和40）上以54.74°的角度定向的偶极子（44,46和48）。 每个偶极子（44,46和48）包括整流装置（50,52和54），并且使用高电阻率引线（58,64）将偶极子（44,46和48）串联耦合到高输入阻抗电压计（24） ，70和74）。 两个热敏电阻（76和78）耦合在三个偶极子（44,46和48）之间，并且高电阻引线装置（80,82,84和86）将热敏电阻耦合到分离的电表（26和28）。