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公开(公告)号：US20170049949A1
公开(公告)日：2017-02-23
申请号：US15257515
申请日：2016-09-06
Applicant: FloDesign Sonics, Inc.
Inventor： Rudolf Gilmanshin , Bart Lipkens , Brian Dutra , Daniel Kennedy
CPC classification number: A61M1/3678 , A61M2202/0427 , A61M2202/0429 , A61M2202/0439 , A61M2202/0456 , B01D21/286 , B01D21/30 , B01D21/34 , B01D2221/10 , B06B1/0644
Abstract: Acoustophoretic devices are disclosed. The devices include a flow chamber, an ultrasonic transducer, a reflector, an inlet, a filtrate outlet, a concentrate outlet, and optionally a lipid collection trap. The ultrasonic transducer and reflector create a multi-dimensional acoustic standing wave in the flow chamber that traps and separates red blood cells and/or lipids from blood. Concentrated red blood cells can be recovered via the concentrate outlet, the lipids can be recovered via the lipid collection trap, and the remaining blood can be recovered via the filtrate outlet. Methods for separating blood components (e.g., red blood cells, lipids, platelets, white blood cells) from blood are also disclosed. The red blood cells can undergo washing with a solvent to remove undesired admixtures. Cryoprotectants can be added or removed from the blood.
Abstract translation: 公开了声学设备。 这些装置包括流动室，超声换能器，反射器，入口，滤液出口，浓缩物出口和任选的脂质收集阱。 超声波换能器和反射器在流动室中产生多维声驻波，其捕获并分离红细胞和/或血液与血液。 可以通过浓缩物出口回收浓缩的红细胞，通过脂质收集阱可以回收脂质，剩余的血液可以通过滤液出口回收。 还公开了从血液中分离血液成分（例如红细胞，脂质，血小板，白细胞）的方法。 红细胞可以用溶剂洗涤以除去不需要的混合物。 可以从血液中加入或除去冷冻保护剂。
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公开(公告)号：US11324873B2
公开(公告)日：2022-05-10
申请号：US15257515
申请日：2016-09-06
Applicant: FloDesign Sonics, Inc.
Inventor： Rudolf Gilmanshin , Bart Lipkens , Brian Dutra , Daniel Kennedy
Abstract: Acoustophoretic devices are disclosed. The devices include a flow chamber, an ultrasonic transducer, a reflector, an inlet, a filtrate outlet, a concentrate outlet, and optionally a lipid collection trap. The ultrasonic transducer and reflector create a multi-dimensional acoustic standing wave in the flow chamber that traps and separates red blood cells and/or lipids from blood. Concentrated red blood cells can be recovered via the concentrate outlet, the lipids can be recovered via the lipid collection trap, and the remaining blood can be recovered via the filtrate outlet. Methods for separating blood components (e.g., red blood cells, lipids, platelets, white blood cells) from blood are also disclosed. The red blood cells can undergo washing with a solvent to remove undesired admixtures. Cryoprotectants can be added or removed from the blood.
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公开(公告)号：US10201652B2
公开(公告)日：2019-02-12
申请号：US13866584
申请日：2013-04-19
Applicant: FloDesign Sonics Inc.
Inventor： Brian Dutra , Bart Lipkens , Daniel Kennedy , Michael J. Rust
Abstract: A system for removing lipids from blood during cardiopulmonary bypass surgery is disclosed. The system uses an acoustophoretic separator having improved trapping force. The transducer of the acoustophoretic seperator includes a ceramic crystal. Blood flows through the separator, and lipids are trapped and removed.
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