公开(公告)号：US20210333173A1

公开(公告)日：2021-10-28

申请号：US17274331

申请日：2019-09-10

Applicant: Fluidigm Canada Inc.

Inventor： DAAF SANDKUIJL ,  Alexander V. Loboda ,  ADAM CAREW ,  MINALINI LAKSHMAN

IPC: G01N1/04 ,  H01J49/04 ,  G01N21/64 ,  H01J49/00

Abstract: This disclosure relates to systems and methods for high speed modulation sample imaging. Disclosed herein are systems and methods for performing imaging mass cytometry, including analysis of labelling atoms by elemental (e.g., atomic) mass spectrometry. Aspects include a sampling system having, and method of using, a femtosecond (fs) laser and/or laser scanning. Alternatively or in addition, aspects include systems and methods for co-registering other imaging modalities with imaging mass cytometry.

公开(公告)号：US20210373313A1

公开(公告)日：2021-12-02

申请号：US17274295

申请日：2019-09-10

Applicant: Fluidigm Canada Inc.

Inventor： DAAF SANDKUIJL ,  Alexander V. Loboda ,  ADAM CAREW ,  KHASHAYAR ASKARPOUR

IPC: G02B21/24 ,  G01N1/04 ,  G01N33/543 ,  G02B21/26 ,  G02B21/00 ,  H01J49/10 ,  H01J49/00

Abstract: We describe in this application systems and methods for autofocusing in imaging mass spectrometry. The present application describes improvements over current IMS and IMC apparatus and methods through an autofocus component including a plurality of apertures in the autofocus system, such as a plurality of apertures arranged in 2 dimensions. As a plurality of apertures is used, the autofocus system provides redundancy in the event that measurement of focus on the sample from the illuminating radiation passed through one or more of the apertures fails so as to reduce the number of unsuccessful autofocus attempts.