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公开(公告)号：AT360801T
公开(公告)日：2007-05-15
申请号：AT97906392
申请日：1997-02-26
Applicant: GE HEALTHCARE BIO SCIENCES AB
Inventor： TORMOD STIG
Abstract: The invention relates to a method of calibrating an optical system, the system comprising a flash lamp as a light source (4), a lens system (6), a monochromator comprising a grating (10), a motor (20) for displacing the grating so as to enable scanning essentially monochromatic light over a detection system. The light source provides at least two high intensity peaks at distinct wavelengths. The method comprises scanning a first wavelength region comprising at least one of said at least two high intensity peaks, and measuring the intensities at a selected number of points during the scan. A first of said at least two peaks is coarsely located. A wavelength region around each of said at least two peaks is scanned, measuring the intensities at closer intervals than previously. At least two peaks are located by autocorrelation. The location of said peaks is determined in terms of a distance from a reference point, said distance corresponding to said displacement of the grating.
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公开(公告)号：CA2631369C
公开(公告)日：2016-09-13
申请号：CA2631369
申请日：2006-11-28
Applicant: GE HEALTHCARE BIO-SCIENCES AB
Inventor： TORMOD STIG
Abstract: The present invention relates to methods and apparatus for detecting and measuring the concentration of a substance in a solution, the substance having an absorption at 300 nm or less. The methods and apparatus have particular utility in detecting and measuring the concentration of proteins and nucleic acids.
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公开(公告)号：ES2286828T3
公开(公告)日：2007-12-01
申请号：ES97906392
申请日：1997-02-26
Applicant: GE HEALTHCARE BIO SCIENCES AB
Inventor： TORMOD STIG
Abstract: LA INVENCION SE REFIERE A UN METODO PARA CALIBRAR UN SISTEMA OPTICO, CUYO SISTEMA COMPRENDE UNA LAMPARA DE DESTELLOS COMO FUENTE LUMINOSA (4), UN SISTEMA DE LENTES (6), UN MONOCROMADOR QUE COMPRENDE UNA REJILLA (10), UN MOTOR (20) PARA DESPLAZAR LA REJILLA Y PERMITIR ASI QUE UNA LUZ ESENCIALMENTE MONOCROMATICA EXPLORE UN SISTEMA DE DETECCION. LA FUENTE LUMINOSA PROPORCIONA AL MENOS DOS CRESTAS DE ALTA INTENSIDAD A DISTINTAS LONGITUDES DE ONDA. EL METODO CONSISTE EN EXPLORAR UNA PRIMERA REGION DE LONGITUDES DE ONDA QUE COMPRENDE AL MENOS UNA DE LAS DOS CRESTAS DE ALTA INTENSIDAD ANTEDICHAS QUE HAY POR LO MENOS Y MEDIR LAS INTENSIDADES EN UNA SERIE DE PUNTOS SELECCIONADA DURANTE LA EXPLORACION. SE LOCALIZA UNA PRIMERA CRESTA DE LAS DOS CRESTAS ANTEDICHAS QUE HAY POR LO MENOS. SE EXPLORA UNA REGION DE LONGITUDES DE ONDA ALREDEDOR DE CADA UNA DE DICHAS DOS CRESTAS QUE HAY POR LO MENOS, MIDIENDO LAS INTENSIDADES A INTERVALOS MENORES QUE ANTES. SE LOCALIZAN AL MENOS DOS CRESTAS POR AUTOCORRELACION. LA LOCALIZACION DE DICHAS CRESTAS SE DETERMINA EN TERMINOS DE UNA DISTANCIA DESDE UN PUNTO DE REFERENCIA, CORRESPONDIENDO DICHA DISTANCIA AL DESPLAZAMIENTO DE LA REJILLA.
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公开(公告)号：DE69737649D1
公开(公告)日：2007-06-06
申请号：DE69737649
申请日：1997-02-26
Applicant: GE HEALTHCARE BIO SCIENCES AB
Inventor： TORMOD STIG
Abstract: The invention relates to a method of calibrating an optical system, the system comprising a flash lamp as a light source (4), a lens system (6), a monochromator comprising a grating (10), a motor (20) for displacing the grating so as to enable scanning essentially monochromatic light over a detection system. The light source provides at least two high intensity peaks at distinct wavelengths. The method comprises scanning a first wavelength region comprising at least one of said at least two high intensity peaks, and measuring the intensities at a selected number of points during the scan. A first of said at least two peaks is coarsely located. A wavelength region around each of said at least two peaks is scanned, measuring the intensities at closer intervals than previously. At least two peaks are located by autocorrelation. The location of said peaks is determined in terms of a distance from a reference point, said distance corresponding to said displacement of the grating.
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Patent Agency Ranking
公开(公告)号：DE69737649T2
公开(公告)日：2008-01-10
申请号：DE69737649
申请日：1997-02-26
Applicant: GE HEALTHCARE BIO SCIENCES AB
Inventor： TORMOD STIG
Abstract: The invention relates to a method of calibrating an optical system, the system comprising a flash lamp as a light source (4), a lens system (6), a monochromator comprising a grating (10), a motor (20) for displacing the grating so as to enable scanning essentially monochromatic light over a detection system. The light source provides at least two high intensity peaks at distinct wavelengths. The method comprises scanning a first wavelength region comprising at least one of said at least two high intensity peaks, and measuring the intensities at a selected number of points during the scan. A first of said at least two peaks is coarsely located. A wavelength region around each of said at least two peaks is scanned, measuring the intensities at closer intervals than previously. At least two peaks are located by autocorrelation. The location of said peaks is determined in terms of a distance from a reference point, said distance corresponding to said displacement of the grating.
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公开(公告)号：CA2631369A1
公开(公告)日：2007-06-07
申请号：CA2631369
申请日：2006-11-28
Applicant: GE HEALTHCARE BIO SCIENCES AB
Inventor： TORMOD STIG
Abstract: The present invention relates to methods and apparatus for detecting and measuring the concentration of a substance in a solution, the substance having an absorption at 300 nm or less. The methods and apparatus have particular utility in detecting and measuring the concentration of proteins and nucleic acids.
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公开(公告)号：EP2350612A4
公开(公告)日：2018-01-10
申请号：EP09827833
申请日：2009-11-23
Applicant: GE HEALTHCARE BIO-SCIENCES AB
Inventor： FRÖJDH HÅKAN , HÖRNQVIST MIKAEL , TORMOD STIG , ÅKERSTRÖM PATRIK
IPC: G01N21/05 , G01J3/02 , G01J3/42 , G01J3/433 , G01N1/10 , G01N21/03 , G01N21/13 , G01N21/33 , G01N21/51
CPC classification number: G01N21/33 , G01J3/0218 , G01J3/0291 , G01J3/42 , G01J3/433 , G01N21/05 , G01N21/51 , G01N2021/0346 , G01N2201/061 , G01N2201/0853 , G01N2201/086
Abstract: The present invention discloses a flow cell optical detection system comprising a light source, a flow cell and a light detector, wherein the light detector is arranged in a separate detector unit that is arranged to be releasably attached to a detector interface, the detector interface being in optical communication with the light source and comprises optical connectors for optically connecting the flow cell and the detector unit in the light path from the light source, and wherein the flow cell is an interchangeable unit arranged to be held in position by the detector unit when attached to the detector interface.
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公开(公告)号：EP2502051A4
公开(公告)日：2013-07-03
申请号：EP10831875
申请日：2010-11-17
Applicant: GE HEALTHCARE BIO SCIENCES AB
Inventor： TORMOD STIG
IPC: G01N21/64 , G01N21/03 , G01N21/25 , G01N33/483 , G02B21/06
CPC classification number: G01N21/6456 , G01N21/255 , G01N21/6454 , G01N21/6458 , G01N2021/6469 , G01N2201/066 , G02B21/16
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公开(公告)号：EP2529198A4
公开(公告)日：2014-02-19
申请号：EP11737364
申请日：2011-01-26
Applicant: GE HEALTHCARE BIO SCIENCES AB
Inventor： TORMOD STIG
CPC classification number: G01N21/05 , G01N21/0303 , G01N2021/0346 , G01N2201/08
Abstract: Optical flow cell detector comprising a sample inlet and outlet in fluidic communication through a flow cell channel of cross sectional area A, an input light guide with an light exit surface arranged adjacent and in optical alignment with a light entrance surface of an output light guide, wherein the input light guide and the output light guide protrudes into the flow cell channel and wherein the distance between the light exit surface and the light entrance surface is less than 1.0 mm, and wherein the cross sectional area of the protruding portions of the input light guide and the output light guide in the flow direction is less than A/2.
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