公开(公告)号：WO1992009296A1

公开(公告)日：1992-06-11

申请号：PCT/US1991008497

申请日：1991-11-20

Applicant: GEORGETOWN UNIVERSITY

Inventor： GEORGETOWN UNIVERSITY ,  FLEMING, Patrick, J. ,  KENT, Ute, M.

IPC: A61K37/00

CPC classification number: C07K16/18 ,  A61K38/00 ,  C07K7/08 ,  C07K14/80 ,  Y10S514/909 ,  Y10S514/91

Abstract: A peptide for regulating weight gain in mammals having formula: alpha beta gamma delta epsilon eta theta lambda mu pi rho sigma , wherein at least six of the amino acid residues are as defined and in the sequential positions specified in the sequence: CHHRKKGYADLY, wherein C is cysteine, H is histidine, R is arginine, K is lysine, G is glycine, Y is tyrosine, A is alanine, D is aspartic acid, and L is leucine; and the remaining amino acids are each independently glycine, alanine, valine, leucine, isoleucine, serine, threonine, cysteine, methionine, aspartic acid, glutamic acid, asparagine, glutamine, lysine, hydroxy lysine, histidine, arginine, phenylalanine, tyrosine, tryptophan, proline or hydroxyproline.

Abstract translation: 一种用于调节哺乳动物体重增加的肽，其具有式：αβγδεδλλλlambda ho igma igma，其中至少六个氨基酸残基如下定义并且在序列中指定的顺序位置：CHHRKKGYADLY，其中C 是半胱氨酸，H是组氨酸，R是精氨酸，K是赖氨酸，G是甘氨酸，Y是酪氨酸，A是丙氨酸，D是天冬氨酸，L是亮氨酸; 剩余的氨基酸各自独立地为甘氨酸，丙氨酸，缬氨酸，亮氨酸，异亮氨酸，丝氨酸，苏氨酸，半胱氨酸，甲硫氨酸，天冬氨酸，谷氨酸，天冬酰胺，谷氨酰胺，赖氨酸，羟基赖氨酸，组氨酸，精氨酸，苯丙氨酸，酪氨酸，色氨酸 ，脯氨酸或羟脯氨酸。