公开(公告)号：WO1997000683A1

公开(公告)日：1997-01-09

申请号：PCT/US1996010751

申请日：1996-06-24

Applicant: GEORGETOWN UNIVERSITY

Inventor： GEORGETOWN UNIVERSITY ,  CLARKE, Robert ,  TALEBIAN, Abdel, H. +di ,  GHIORGHIS, Alem ,  LEONESSA, Fabio ,  HAMMER, Charles

IPC: A61K31/57

CPC classification number: C07J41/005

Abstract: The present invention is directed to novel progesterone derivatives, as well as to pharmaceutical compositions thereof, and methods of treatment using the derivatives. More particularly, the invention relates to C7-substituted derivatives of the pregnene series. The present invention is directed to methods of treating multidrug-resistant tumors, and especially breast tumors, with novel C7-substituted progesterone analogs.

Abstract translation: 本发明涉及新颖的孕酮衍生物及其药物组合物，以及使用衍生物的治疗方法。 更具体地，本发明涉及孕烯系列的C7-取代的衍生物。 本发明涉及用新型C7-取代的孕酮类似物治疗多药耐药性肿瘤，特别是乳腺肿瘤的方法。

公开(公告)号：EP0859618A1

公开(公告)日：1998-08-26

申请号：EP96922550.0

申请日：1996-06-24

Applicant: GEORGETOWN UNIVERSITY

Inventor： CLARKE, Robert ,  GHIORGHIS, Alem ,  LEONESSA, Fabio ,  HAMMER, Charles

IPC: C07J41

CPC classification number: C07J41/005

Abstract: The present invention is directed to novel progesterone derivatives, as well as to pharmaceutical compositions thereof, and methods of treatment using the derivatives. More particularly, the invention relates to C7-substituted derivatives of the pregnene series. The present invention is directed to methods of treating multidrug-resistant tumors, and especially breast tumors, with novel C7-substituted progesterone analogs.