公开(公告)号：WO2006029538A8

公开(公告)日：2006-06-01

申请号：PCT/CA2005001432

申请日：2005-09-16

Applicant: CA NAT RESEARCH COUNCIL ,  GILBERT MICHEL ,  WAKARCHUK WARREN W

Inventor： GILBERT MICHEL ,  WAKARCHUK WARREN W

IPC: C12N15/54 ,  C12N9/10 ,  C12P19/00 ,  C12P21/02

CPC classification number: C12P19/26 ,  C12N9/1081

Abstract: The present invention provides, e.g., sialyltransferase proteins comprising conserved sequence motifs, including a-2,3-sialyltransferase proteins from C. jejuni strains O:36 and O:19. The invention also provides methods of making sialylated products using those sialyltransferases.

Abstract translation: 本发明提供了例如包含保守序列基序的唾液酸转移酶蛋白，包括空肠弯曲杆菌菌株O：36和O：19的2,3-唾液酸转移酶蛋白。 本发明还提供使用这些唾液酸转移酶制备唾液酸化产物的方法。

公开(公告)号：WO02074942B1

公开(公告)日：2003-07-03

申请号：PCT/CA0200229

申请日：2002-02-22

Applicant: CA NAT RESEARCH COUNCIL ,  GILBERT MICHEL ,  WAKARCHUK WARREN W

Inventor： GILBERT MICHEL ,  WAKARCHUK WARREN W

IPC: C12N15/09 ,  C12N1/21 ,  C12N9/10 ,  C12N9/12 ,  C12N9/88 ,  C12N15/54 ,  C12P19/18 ,  C12N5/10 ,  C12Q1/68

CPC classification number: C12N9/1241 ,  C12N9/1029 ,  C12N9/1048 ,  C12N9/1051 ,  C12N9/1081 ,  C12P19/18

Abstract: This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an alpha 2,3- and an alpha 2,8-activity. A beta 1,4-GalNAc transferase and a beta 1,3-galactosyltransferase are also provided by the invention, as are other glycosyltransferases and enzymes involved in synthesis of lipooligosaccharide (LOS). The glycosyltransferases can be obtained from, for example, Campylobacter species, including C. jejuni. In additional embodiments, the invention provides nucleic acids that encode the glycosyltransferases, as well as expression vectors and host cells for expressing the glycosyltransferases.

Abstract translation: 本发明提供了原核糖基转移酶，包括具有α2B和α2,8-活性的双官能唾液酸转移酶。 本发明还提供了β1,4-GalNAc转移酶和β1,3-半乳糖基转移酶，以及参与脂寡糖（LOS）合成的其它糖基转移酶和酶也是如此。 糖基转移酶可以从例如弯曲杆菌属物种获得，包括空肠弯曲杆菌。 在另外的实施方案中，本发明提供编码糖基转移酶的核酸，以及用于表达糖基转移酶的表达载体和宿主细胞。

公开(公告)号：US1754481A

公开(公告)日：1930-04-15

申请号：US26025628

申请日：1928-03-08

Applicant: GILBERT MICHEL

Inventor： GILBERT MICHEL

IPC: C09D5/08

CPC classification number: C09D5/08 ,  Y10T428/31688

公开(公告)号：US1854271A

公开(公告)日：1932-04-19

申请号：US19031627

申请日：1927-05-10

Applicant: GILBERT MICHEL

Inventor： GILBERT MICHEL

IPC: F02F3/10

CPC classification number: F02F3/10 ,  F02F2200/04 ,  F05C2201/028 ,  Y10T29/49252 ,  Y10T29/49263

公开(公告)号：US1720286A

公开(公告)日：1929-07-09

申请号：US12672726

申请日：1926-08-02

Applicant: GILBERT MICHEL

Inventor： GILBERT MICHEL

IPC: C22B26/22

CPC classification number: C22B26/22