公开(公告)号：GB2295387A

公开(公告)日：1996-05-29

申请号：GB9423635

申请日：1994-11-23

Applicant: GLAXO INC

Inventor： ANDREWS ROBERT CARL ,  BROWN PETER JONATHAN ,  DEATON DAVID NORMAN ,  DREWRY DAVID HAROLD ,  FOLEY MICHAEL ANDREW ,  GARRISON DEANNA T ,  MARRON BRIAN EDWARD ,  SMALLEY TERRENCE L ,  BERMAN JUDD M ,  NOBLE STEWART ALYWYN

IPC: C07D239/74 ,  C07D239/93 ,  C07D239/94 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D407/12 ,  C07D471/04 ,  C07D473/08 ,  C07D473/10 ,  C07D487/04 ,  C07D487/08 ,  C07D239/72 ,  A61K31/505

Abstract: wherein: R is selected from hydrogen, C1-6alkyl, C1-6cycloalkyl, hydroxy, C1-6alkoxy, -COO(C1-6alkyl), halogen, phenyl, phenylcarbonyl, substituted phenyl, pyridinyl, pyrimidinyl or pyrrolyl; n is 0 or 1; R is a C1-6alkylene chain optionally mono- or disubstituted independently with hydrogen, C1-6alkyl, hydroxy, C1-6alkoxy, flouro, phenyl or substituted phenyl substituents; R and R are independently selected from the group consisting of hydrogen, C1-6alkyl, hydroxy, C1-6alkoxy or halogen; and R and R are as defined in the specification; and salts thereof are useful for treating benign prostatic hyperplasia.